KEGG   PATHWAY: nsu05203
Entry
nsu05203                    Pathway                                
Name
Viral carcinogenesis - Neomonachus schauinslandi (Hawaiian monk seal)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
nsu05203  Viral carcinogenesis
nsu05203

Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110579592  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
110582206  HRAS; GTPase HRas isoform X1 [KO:K02833]
123323805  GTPase HRas-like [KO:K02833]
110580861  KRAS; GTPase KRas isoform X1 [KO:K07827]
110580342  NRAS; GTPase NRas [KO:K07828]
110589825  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110578336  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110592296  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
110592390  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110578169  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110581463  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X2 [KO:K09048]
110582887  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
110575757  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
110593955  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110573501  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
110580150  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
110586851  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
110576315  DDB1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
110585121  14-3-3 protein beta/alpha-like [KO:K16197]
110583204  14-3-3 protein zeta/delta-like [KO:K16197]
110579154  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
110579297  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
110587533  YWHAQ; 14-3-3 protein theta [KO:K16197]
110592805  YWHAE; 14-3-3 protein epsilon [KO:K06630]
110589853  YWHAG; 14-3-3 protein gamma [KO:K16198]
110592574  YWHAH; 14-3-3 protein eta [KO:K16198]
110571840  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110573316  STAT3; signal transducer and activator of transcription 3 isoform X5 [KO:K04692]
110573273  signal transducer and activator of transcription 5B [KO:K11224]
110584089  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
110590118  HPN; serine protease hepsin isoform X1 [KO:K08665] [EC:3.4.21.106]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110575986  RELA; transcription factor p65 [KO:K04735]
110588781  REL; proto-oncogene c-Rel [KO:K09254]
110589069  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110572155  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110584444  TP53; cellular tumor antigen p53 [KO:K04451]
110590303  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
110579138  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
110577806  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
110589200  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
110588546  EGR3; early growth response protein 3 isoform X1 [KO:K12497]
110573114  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
110581090  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
110591560  SP100; nuclear autoantigen Sp-100 [KO:K15413]
110569992  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
110575681  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110581163  ATP-dependent RNA helicase DDX3X-like isoform X6 [KO:K11594] [EC:5.6.2.7]
110573514  DDX3X; ATP-dependent RNA helicase DDX3X isoform X2 [KO:K11594] [EC:5.6.2.7]
110587259  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
110580659  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
110594123  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123324586  histone H2B type 2-E [KO:K11252]
110589700  histone H2B subacrosomal variant-like [KO:K11252]
110586611  histone H2B type 1-B [KO:K11252]
123325493  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
110582778  histone H2B type 2-E1 [KO:K11252]
123325518  histone H2B type 1-C/E/F/G/I [KO:K11252]
123325519  histone H2B type 1-C/E/F/G/I [KO:K11252]
110583620  histone H2B type 1-A [KO:K11252]
110583630  histone H2B type 1-A-like [KO:K11252]
110570026  late histone H2B.L4-like [KO:K11252]
110578172  late histone H2B.L4-like [KO:K11252]
110578552  histone H2B type 2-F [KO:K11252]
123323183  histone H2B type 1-C/E/F/G/I [KO:K11252]
110586648  histone H2B type 1-K [KO:K11252]
110586875  histone H2B type 1-K [KO:K11252]
123323756  probable histone H2B 4 [KO:K11252]
123323826  histone H2B type 2-E [KO:K11252]
110572854  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
110572604  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110592808  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
110589242  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
110578287  LOW QUALITY PROTEIN: cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
110583080  TATA-box-binding protein [KO:K03120]
110590692  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
110583347  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
110576654  TATA box-binding protein-like 1 [KO:K03120]
110588043  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
110570608  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110571350  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
110579345  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
110589396  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
110571481  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
110576247  GTF2H1; LOW QUALITY PROTEIN: general transcription factor IIH subunit 1 [KO:K03141]
110589766  general transcription factor IIH subunit 2 [KO:K03142]
110588286  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
110586847  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
110582448  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
110584070  GTF2E2; transcription initiation factor IIE subunit beta [KO:K03137]
110589064  SND1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
110588014  CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
110577947  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110580339  GTF2B; transcription initiation factor IIB isoform X1 [KO:K03124]
110576391  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110580853  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110582036  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110579972  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110575554  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
110570307  CCNA1; cyclin-A1 [KO:K06627]
110573041  CCNA2; cyclin-A2 [KO:K06627]
110586053  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110586753  MRPS18B; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
110581352  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
110581233  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110571685  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
110573917  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
110574431  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110579039  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
110584304  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
110578676  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
110594246  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
110572357  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
110582548  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
110579197  SCRIB; protein scribble homolog [KO:K16175]
110592586  PXN; paxillin isoform X1 [KO:K05760]
110575593  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
110572882  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
110583235  26S proteasome regulatory subunit 4-like [KO:K03062]
110571657  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
110579773  RB1; retinoblastoma-associated protein [KO:K06618]
110579353  RBL1; retinoblastoma-like protein 1 [KO:K04681]
110594280  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
110580846  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
110575153  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
110575086  JUN; transcription factor AP-1 isoform X1 [KO:K04448]
110581069  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
110578860  histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
110575214  HDAC1; LOW QUALITY PROTEIN: histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110583689  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110591309  HDAC3; histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
110570931  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
110573296  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
110593599  HDAC7; histone deacetylase 7 [KO:K11408] [EC:3.5.1.98]
110572396  HDAC8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
110580081  HDAC9; histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
110577975  HDAC10; polyamine deacetylase HDAC10 [KO:K18671] [EC:3.5.1.98]
110584892  HDAC11; histone deacetylase 11 isoform X2 [KO:K11418] [EC:3.5.1.98]
110583896  PKM; pyruvate kinase PKM isoform X3 [KO:K00873] [EC:2.7.1.40]
110585591  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110588071  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X2 [KO:K09504]
110570667  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
110573232  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
110590359  GTF2A1L; TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
110571490  GTF2A1; transcription initiation factor IIA subunit 1 isoform X1 [KO:K03122]
110571813  transcription initiation factor IIA subunit 2-like [KO:K03123]
110583843  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
110585351  transcription initiation factor IIA subunit 2 [KO:K03123]
110581974  SRF; serum response factor isoform X1 [KO:K04378]
110574194  IKBKG; NF-kappa-B essential modulator [KO:K07210]
110585142  NFKBIA; NF-kappa-B inhibitor alpha isoform X2 [KO:K04734]
110570821  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
110575167  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123325993  cell division control protein 42 homolog [KO:K04393]
110577050  cell division control protein 42 homolog [KO:K04393]
110572663  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110571294  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
110577553  RHOA; transforming protein RhoA [KO:K04513]
110579949  SCIN; adseverin [KO:K05768]
110581791  GSN; gelsolin isoform X1 [KO:K05768]
110590342  ACTN4; alpha-actinin-4 isoform X2 [KO:K05699]
110571716  ACTN1; alpha-actinin-1 [KO:K05699]
110577858  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110572649  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
110572647  cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
110586234  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
110574970  CDC20; cell division cycle protein 20 homolog [KO:K03363]
110571948  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
110592132  VAC14; protein VAC14 homolog [KO:K15305]
110581112  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
110590676  ran-specific GTPase-activating protein-like [KO:K15306]
110573112  POLB; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
110582214  IRF7; interferon regulatory factor 7 [KO:K09447]
110590912  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
110574370  C-C chemokine receptor type 5 [KO:K04180]
110594319  CCR8; C-C chemokine receptor type 8 [KO:K04183]
110574373  CCR3; C-C chemokine receptor type 3 [KO:K04178]
110569621  CCR4; C-C chemokine receptor type 4 [KO:K04179]
110574092  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
110592166  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110575945  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110577139  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X1 [KO:K10131]
110593993  C3; complement C3 [KO:K03990]
110580263  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
110575688  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
110586919  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A alpha chain [KO:K06751]
110581264  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
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Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
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Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
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Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
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Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Reference
PMID:16039586
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Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
Reference
PMID:16939421
  Authors
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DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
nsu03022  Basal transcription factors
nsu03320  PPAR signaling pathway
nsu04010  MAPK signaling pathway
nsu04062  Chemokine signaling pathway
nsu04064  NF-kappa B signaling pathway
nsu04110  Cell cycle
nsu04115  p53 signaling pathway
nsu04142  Lysosome
nsu04151  PI3K-Akt signaling pathway
nsu04210  Apoptosis
nsu04630  JAK-STAT signaling pathway
nsu04662  B cell receptor signaling pathway
nsu04810  Regulation of actin cytoskeleton
nsu05160  Hepatitis C
nsu05161  Hepatitis B
nsu05165  Human papillomavirus infection
nsu05166  Human T-cell leukemia virus 1 infection
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05169  Epstein-Barr virus infection
KO pathway
ko05203   
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