KEGG   PATHWAY: ocu04714
Entry
ocu04714                    Pathway                                
Name
Thermogenesis - Oryctolagus cuniculus (rabbit)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
ocu04714  Thermogenesis
ocu04714

Other DBs
GO: 1990845
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100339100  LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
100008904  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
100346323  neuroendocrine secretory protein 55 [KO:K04632]
103347035  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100009201  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100343958  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100346742  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100354934  adenylate cyclase type 6 isoform X8 [KO:K08046] [EC:4.6.1.1]
100357357  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100337882  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100340877  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100008902  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
100348238  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
108176203  histone-lysine N-methyltransferase PRDM16 [KO:K22410] [EC:2.1.1.367]
100345990  zinc finger protein 516 [KO:K22411]
100358443  lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
100328618  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
100358329  lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
100346181  lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
100347453  transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
100350883  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 [KO:K11648]
100353776  SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
100343712  SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
127491145  SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
100345769  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X3 [KO:K11650]
100350037  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
100339222  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
100338684  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
100353758  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like [KO:K11651]
100008822  actin, cytoplasmic 1 [KO:K05692]
100009272  ACTB; actin, cytoplasmic 1 [KO:K05692]
100341037  LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [KO:K05692]
100338581  actin-like protein 6A [KO:K11340]
100357059  actin-like protein 6B [KO:K11652]
100354040  AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
100344334  AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
100349069  zinc finger protein neuro-d4 isoform X2 [KO:K22198]
100344508  zinc finger protein DPF3 isoform X2 [KO:K22198]
100008892  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
100340498  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100339953  dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
100350614  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
103346035  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100344161  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100341695  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100349219  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
100355367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100356340  fibroblast growth factor 21 [KO:K22429]
100339941  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
127486103  LOW QUALITY PROTEIN: patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
100338398  monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
100340670  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
100358166  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100348780  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100340412  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100353180  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
100356542  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
100352581  5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
100341777  glucagon isoform X2 [KO:K05259]
103350213  bone morphogenetic protein 8B isoform X1 [KO:K16622]
100341360  bone morphogenetic protein 8B isoform X1 [KO:K16622]
100339826  cannabinoid receptor 1 [KO:K04277]
100009087  NPPA; natriuretic peptides A precursor [KO:K12334]
103352511  natriuretic peptides B isoform X1 [KO:K12335]
100343663  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100008694  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
100008781  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
100354505  beta-klotho isoform X1 [KO:K22404]
100351861  fibroblast growth factor receptor 1 isoform X5 [KO:K04362] [EC:2.7.10.1]
100349995  fibroblast growth factor receptor substrate 2 [KO:K12461]
100342500  growth factor receptor-bound protein 2 [KO:K04364]
100356615  son of sevenless homolog 1 isoform X1 [KO:K03099]
100346391  son of sevenless homolog 2 isoform X1 [KO:K03099]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
100344451  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100341883  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100358702  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100338014  ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
100349186  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100338695  hamartin [KO:K07206]
100351640  tuberin isoform X1 [KO:K07207]
100348492  GTP-binding protein Rheb [KO:K07208]
103346553  regulatory-associated protein of mTOR [KO:K07204]
127482734  regulatory-associated protein of mTOR [KO:K07204]
100356164  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100359276  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
127489858  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
100009260  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
127484730  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108178879  40S ribosomal protein S6 [KO:K02991]
100339133  40S ribosomal protein S6 [KO:K02991]
100338367  40S ribosomal protein S6 [KO:K02991]
100339973  40S ribosomal protein S6-like [KO:K02991]
100343251  40S ribosomal protein S6-like [KO:K02991]
100346495  40S ribosomal protein S6-like [KO:K02991]
100348810  40S ribosomal protein S6-like [KO:K02991]
108175483  40S ribosomal protein S6-like [KO:K02991]
127487210  40S ribosomal protein S6-like [KO:K02991]
100328719  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
100354503  long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
100344347  long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
100342485  long-chain-fatty-acid--CoA ligase 4 isoform X2 [KO:K01897] [EC:6.2.1.3]
100358351  fatty acid CoA ligase Acsl3 isoform X2 [KO:K01897] [EC:6.2.1.3]
127486972  long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
808226  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808230  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808221  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808225  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808222  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808224  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808223  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100341941  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
100352168  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100355349  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100344233  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
100342714  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100345307  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
127490235  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
127486867  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
127486372  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100358684  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2 [KO:K03943] [EC:7.1.1.2]
103346740  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
100351141  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100356593  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
100347823  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108175419  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
100348563  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100349288  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
100352718  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100347938  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100352330  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100342678  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100349320  acyl carrier protein, mitochondrial [KO:K03955]
100341993  acyl carrier protein, mitochondrial-like [KO:K03955]
100349642  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100355529  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103346555  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103348994  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
127484881  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
100350704  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100354603  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100345777  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100339082  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100347288  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
127488114  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100346817  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100008594  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
127486440  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
127486401  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100339424  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
103350693  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100347545  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100348510  complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
100353024  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 isoform X6 [KO:K18160]
100355126  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
100356197  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
100337968  arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
100358419  NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
100338468  protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
100344587  protein arginine methyltransferase NDUFAF7, mitochondrial-like [KO:K18164]
127489969  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
100328584  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
100328585  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
103350026  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
100346169  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
108175360  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
100341256  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
100350787  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
100348135  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
808227  CYTB; cytochrome b [KO:K00412]
127486945  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100347571  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100347143  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100356308  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
100343982  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100337966  cytochrome b-c1 complex subunit 7 isoform X2 [KO:K00417]
100338219  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
100358208  cytochrome b-c1 complex subunit 9 [KO:K00419]
100347864  cytochrome b-c1 complex subunit 9-like [KO:K00419]
103349485  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 10 [KO:K00420]
127485529  cytochrome b-c1 complex subunit 10 [KO:K00420]
808231  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808233  COX2; cytochrome c oxidase subunit II [KO:K02261]
808229  COX3; cytochrome c oxidase subunit III [KO:K02262]
100327269  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [KO:K02263]
100345745  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100346411  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100343793  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100341474  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100341219  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100327270  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial precursor [KO:K02266]
100346670  cytochrome c oxidase subunit 6B1 [KO:K02267]
100355422  cytochrome c oxidase subunit 6B1-like [KO:K02267]
100352363  cytochrome c oxidase subunit 6C [KO:K02268]
100340645  cytochrome c oxidase subunit 6C [KO:K02268]
108176887  cytochrome c oxidase subunit 6C [KO:K02268]
100356756  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
103349801  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100358239  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100345955  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
127484381  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
127484606  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
127492394  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
100353320  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100339628  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100342996  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100357660  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
100348984  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
100356786  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
108175479  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108177262  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108177708  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108178067  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
100343255  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100354254  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
100356833  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
100338343  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
100339718  cytochrome c oxidase assembly protein COX14 [KO:K18181]
100355645  cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
100339352  LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
100352275  cytochrome c oxidase copper chaperone [KO:K02260]
100355311  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X2 [KO:K17797]
100349428  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X3 [KO:K18184]
100354547  LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX20, mitochondrial-like [KO:K18184]
100352100  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
100357033  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
100340218  cytochrome c oxidase assembly factor 5 [KO:K18178]
100354303  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
100355134  cytochrome c oxidase assembly factor 7 [KO:K18180]
100356563  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100341772  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
100353514  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
127487406  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100353292  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X3 [KO:K02136]
127489209  ATP synthase subunit delta, mitochondrial [KO:K02134]
108175623  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
100328815  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
808232  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100359144  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100351840  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100354074  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
100345365  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100351820  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100351492  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100343693  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
100346750  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
100344371  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
103346545  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
108178113  ATP synthase subunit e, mitochondrial [KO:K02129]
100345802  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
100346096  ATP synthase subunit f, mitochondrial [KO:K02130]
100350580  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
100339009  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100350526  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100344154  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
100344965  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
808228  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100353482  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
100346210  carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
100349627  mitochondrial basic amino acids transporter isoform X4 [KO:K15109]
100352079  mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
100350311  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
100350716  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
103346593  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
100353138  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
100341327  carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
ocu00020  Citrate cycle (TCA cycle)
ocu00190  Oxidative phosphorylation
ocu04010  MAPK signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04024  cAMP signaling pathway
ocu04150  mTOR signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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