KEGG   PATHWAY: oga04110
Entry
oga04110                    Pathway                                
Name
Cell cycle - Otolemur garnettii (small-eared galago)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
oga04110  Cell cycle
oga04110

Other DBs
GO: 0000278
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100958947  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100962188  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100945148  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100960589  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100952236  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100951476  RB1; retinoblastoma-associated protein [KO:K06618]
100959012  RBL1; retinoblastoma-like protein 1 [KO:K04681]
100963426  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100961758  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
100942963  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100965265  HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
100949586  LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
100957114  E2F1; transcription factor E2F1 [KO:K17454]
100956861  E2F2; transcription factor E2F2 [KO:K09389]
100942819  E2F3; transcription factor E2F3 [KO:K06620]
100950658  E2F4; transcription factor E2F4 [KO:K04682]
100959904  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
100940771  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
100948304  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
100952751  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
100949640  TGFB1; transforming growth factor beta-1 isoform X2 [KO:K13375]
100956747  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
100955213  TGFB3; transforming growth factor beta-3 [KO:K13377]
100960336  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100962223  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
100955502  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
100952981  MYC; myc proto-oncogene protein [KO:K04377]
100943501  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X2 [KO:K10500]
100943080  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100955700  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100947399  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100960098  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
100964179  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
100956215  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
100946725  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100958215  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100959381  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
100964880  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100947924  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100962270  CUL1; cullin-1 [KO:K03347]
100963359  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
100942708  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
100942167  CCNA1; cyclin-A1 [KO:K06627]
100966485  CCNA2; cyclin-A2 [KO:K06627]
100948594  CDC6; cell division control protein 6 homolog [KO:K02213]
100941516  CDT1; DNA replication factor Cdt1 [KO:K10727]
100952460  ORC1; origin recognition complex subunit 1 [KO:K02603]
100940475  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
100942805  ORC3; origin recognition complex subunit 3 isoform X2 [KO:K02605]
100944529  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
100955806  ORC5; origin recognition complex subunit 5 [KO:K02607]
100955452  ORC6; origin recognition complex subunit 6 [KO:K02608]
100951585  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
100948408  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
100944057  MCM4; LOW QUALITY PROTEIN: DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
100964416  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
100950536  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
100947282  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
100957910  CDC45; cell division control protein 45 homolog [KO:K06628]
100959739  TICRR; treslin [KO:K26117]
100966617  MTBP; mdm2-binding protein [KO:K26116]
100952992  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
100942761  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
100949756  DBF4B; LOW QUALITY PROTEIN: protein DBF4 homolog B [KO:K06629]
100943441  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100945632  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100946063  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100966515  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
100953192  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
100944047  G2/mitotic-specific cyclin-B1-like [KO:K05868]
100964113  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100954763  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
100962357  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
100964410  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
100958798  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100945575  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha-like [KO:K16197]
100953470  14-3-3 protein zeta/delta [KO:K16197]
100953720  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100948188  YWHAQ; 14-3-3 protein theta [KO:K16197]
100959168  YWHAE; 14-3-3 protein epsilon [KO:K06630]
100944008  YWHAH; 14-3-3 protein eta [KO:K16198]
100940414  YWHAG; 14-3-3 protein gamma [KO:K16198]
100942948  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
100953461  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
100948859  WEE1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
100963735  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
100956776  CCNH; cyclin-H isoform X1 [KO:K06634]
100951646  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
100947081  ANAPC1; anaphase-promoting complex subunit 1 isoform X2 [KO:K03348]
100962072  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
100950079  CDC27; cell division cycle protein 27 homolog isoform X3 [KO:K03350]
100941778  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
100958930  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100966406  CDC16; cell division cycle protein 16 homolog [KO:K03353]
100956834  ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
100963342  CDC23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
100950723  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100951016  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
100949416  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
100960160  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100944335  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
100964667  anaphase-promoting complex subunit 16-like isoform X1 [KO:K25229]
100953302  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
100949305  CDC20; cell division cycle protein 20 homolog [KO:K03363]
100959487  PTTG1; securin isoform X1 [KO:K06635]
100964680  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
100943190  SMC1B; structural maintenance of chromosomes protein 1B [KO:K06636]
100941231  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
100948184  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
100945097  double-strand-break repair protein rad21 homolog [KO:K06670]
100947086  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
100948692  STAG2; cohesin subunit SA-2 isoform X2 [KO:K06671]
100962672  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
100952788  ATRX; transcriptional regulator ATRX isoform X5 [KO:K10779]
100961431  DDX11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
100943342  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
100941169  MAU2; MAU2 chromatid cohesion factor homolog [KO:K11266]
100951118  HDAC8; histone deacetylase 8 isoform X3 [KO:K11405] [EC:3.5.1.98]
100955773  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
100962024  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
100953096  PDS5B; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
100948775  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
100956056  WAPL; wings apart-like protein homolog [KO:K25163]
100947701  CDCA5; sororin [KO:K17390]
100956076  AURKB; aurora kinase B [KO:K11479] [EC:2.7.11.1]
100949826  SGO1; shugoshin 1 isoform X1 [KO:K11580]
100949483  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100947082  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
100959676  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100957401  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100945821  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
100944450  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8 [KO:K11584]
100960529  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100951347  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100942940  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
100948707  kinetochore protein NDC80 homolog [KO:K11547]
100961960  KNL1; kinetochore scaffold 1 [KO:K11542]
100952014  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
100958927  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
100957931  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100948144  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100959349  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X2 [KO:K13728]
100951988  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
100952525  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
100948031  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
100964431  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
100959966  MAD2L1BP; MAD2L1-binding protein isoform X1 [KO:K26093]
100951767  FZR1; fizzy-related protein homolog isoform X2 [KO:K03364]
100953587  FBXO5; F-box only protein 5 [KO:K10292]
100958001  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
100961385  CDC14A; dual specificity protein phosphatase CDC14A isoform X2 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
100943144  CREBBP; CREB-binding protein isoform X3 [KO:K04498] [EC:2.3.1.48]
100963040  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100946687  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
100949565  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
100947578  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100961605  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
100947328  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
100953808  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
111727809  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
100963622  TP53; cellular tumor antigen p53 [KO:K04451]
100946928  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100950782  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100950842  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X2 [KO:K04402]
100957112  PCNA; proliferating cell nuclear antigen [KO:K04802]
100946778  SFN; 14-3-3 protein sigma [KO:K06644]
100942218  CHEK1; serine/threonine-protein kinase Chk1 isoform X2 [KO:K02216] [EC:2.7.11.1]
100959652  CHEK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
100942877  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
oga03030  DNA replication
oga04010  MAPK signaling pathway
oga04120  Ubiquitin mediated proteolysis
oga04210  Apoptosis
KO pathway
ko04110   
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