Entry Name Progesterone-mediated oocyte maturation - Onychostoma macrolepis
Description Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map omc04914 Progesterone-mediated oocyte maturation
Ortholog table Other DBs Organism Onychostoma macrolepis [GN:
omc ]
Gene 131541975 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
131552189 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
131540458 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
131532182 zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
131532482 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
131549562 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
131554420 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
131541907 gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630 ]
131549022 gnai2a; guanine nucleotide-binding protein G(i) subunit alpha-2a [KO:K04630 ]
131534479 gnaia; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a [KO:K04630 ]
131545465 gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630 ]
131538867 gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
131536154 prkacaa; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345 ] [EC:2.7.11.11 ]
131532125 cpeb2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602 ]
131534440 cpeb1a; cytoplasmic polyadenylation element-binding protein 1a isoform X1 [KO:K02602 ]
131544914 cpeb1b; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602 ]
131552086 cpeb3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602 ]
131528447 cpeb4b; cytoplasmic polyadenylation element-binding protein 4b isoform X1 [KO:K02602 ]
131553519 cpeb4a; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602 ]
131526591 hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079 ]
131550861 pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633 ] [EC:2.7.11.1 ]
131536748 mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679 ]
131544334 mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537 ]
131545446 mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728 ]
131552726 anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
131537931 cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350 ]
131527737 anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351 ]
131529057 cdc23; cell division cycle protein 23 homolog isoform X1 [KO:K03355 ]
131542764 anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference Authors Schmitt A, Nebreda AR.
Title Signalling pathways in oocyte meiotic maturation.
Journal J Cell Sci 115:2457-9 (2002)
Reference Authors Cato AC, Nestl A, Mink S.
Title Rapid actions of steroid receptors in cellular signaling pathways.
Journal Reference Authors Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
Title The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Journal Reference Authors Nebreda AR, Ferby I.
Title Regulation of the meiotic cell cycle in oocytes.
Journal Reference Authors Ferrell JE Jr.
Title Xenopus oocyte maturation: new lessons from a good egg.
Journal Reference Authors Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Title Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Journal Reference Authors Duckworth BC, Weaver JS, Ruderman JV.
Title G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Journal Reference Authors Abrieu A, Doree M, Fisher D.
Title The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
Journal J Cell Sci 114:257-67 (2001)
Related KO pathway LinkDB All DBs
