KEGG   PATHWAY: pcoo04714
Entry
pcoo04714                   Pathway                                
Name
Thermogenesis - Puma concolor (puma)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
pcoo04714  Thermogenesis
pcoo04714

Other DBs
GO: 1990845
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112858503  ADRB3; beta-3 adrenergic receptor [KO:K04143]
112869078  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
112869430  neuroendocrine secretory protein 55 [KO:K04632]
112859788  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112860207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112864041  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
112855238  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112849881  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112867731  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112857348  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112859389  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
112853291  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112862880  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
112863114  ADCY10; LOW QUALITY PROTEIN: adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
112852313  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112871920  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112848555  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112851773  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112852536  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
112865439  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
112871786  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
112866754  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
112866756  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
112868437  ZNF516; zinc finger protein 516 [KO:K22411]
112870421  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
112858081  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
112864208  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
112860659  KDM3B; LOW QUALITY PROTEIN: lysine-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
112868554  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
112852276  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
112870520  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
112863757  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
112852436  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
112864458  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
112867511  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
112854097  SMARCE1; LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
112864619  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112860092  ACTB; actin, cytoplasmic 1 [KO:K05692]
112850465  ACTL6A; actin-like protein 6A [KO:K11340]
112859922  ACTL6B; actin-like protein 6B [KO:K11652]
112862239  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
112862525  ARID1A; AT-rich interactive domain-containing protein 1A [KO:K11653]
112854959  DPF3; zinc finger protein DPF3 [KO:K22198]
112850982  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
112859366  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
112862885  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112857077  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112862836  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112862837  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
112863384  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112858075  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
112848765  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112852540  SIRT6; NAD-dependent protein deacetylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
112851220  FGF21; fibroblast growth factor 21 [KO:K22429]
112856094  PLIN1; perilipin-1 [KO:K08768]
112851328  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
112852074  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
112858234  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
112871770  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
112861156  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112869010  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
112870095  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
112866705  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
112867041  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
112867175  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112848419  GCG; glucagon [KO:K05259]
112871789  BMP8A; bone morphogenetic protein 8A [KO:K16622]
112862300  CNR1; cannabinoid receptor 1 [KO:K04277]
112861584  NPPA; natriuretic peptides A [KO:K12334]
112861593  NPPB; natriuretic peptides B [KO:K12335]
112851728  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
112851475  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
112858125  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
112858673  KLB; beta-klotho [KO:K22404]
112858029  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112863500  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
112864567  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
112855446  SOS2; son of sevenless homolog 2 [KO:K03099]
112864130  SOS1; son of sevenless homolog 1 [KO:K03099]
112868012  KRAS; GTPase KRas isoform X1 [KO:K07827]
112848478  NRAS; GTPase NRas [KO:K07828]
112849257  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
112870736  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
112871593  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
112871992  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112871843  TSC1; hamartin [KO:K07206]
112853203  TSC2; tuberin [KO:K07207]
112866512  RHEB; GTP-binding protein Rheb [KO:K07208]
112848905  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112853257  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
112850817  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
112852203  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112866810  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
112866994  RPS6; 40S ribosomal protein S6 [KO:K02991]
112861637  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
112870012  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
112871238  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
112848542  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
112854869  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
11473378  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
11473379  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
11473385  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
11473377  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
11473386  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
11473374  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
11473375  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
112869732  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
112851625  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112865371  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112860962  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
112872093  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112861125  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112852781  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112851977  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
112852033  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
112868105  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
112850447  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
112871256  NDUFA1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112859395  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
112861044  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
112851148  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
112863770  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
112866744  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112850499  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
112866670  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
112863619  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112871796  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112867527  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112867674  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112853284  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112852859  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112863598  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112852861  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112856171  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112866888  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112848529  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112850222  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112849670  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
112861170  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
112854315  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
112859401  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
112853318  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
112870588  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112858442  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112865346  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
112855614  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
112861117  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
112852647  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
112862579  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
112868985  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
112859246  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
112864233  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
112864680  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 isoform X1 [KO:K24726]
112860213  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112871838  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112851739  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112865224  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
112860597  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
112850981  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
11473376  CYTB; cytochrome b [KO:K00412]
112859467  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112852534  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112853229  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112869979  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112859521  cytochrome b-c1 complex subunit 7 [KO:K00417]
112861315  cytochrome b-c1 complex subunit 8 [KO:K00418]
112870212  cytochrome b-c1 complex subunit 9 [KO:K00419]
11473380  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
11473381  COX2; cytochrome c oxidase subunit II [KO:K02261]
11473384  COX3; cytochrome c oxidase subunit III [KO:K02262]
112869546  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
112857357  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112855929  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112868931  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112857263  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
112870298  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112851056  cytochrome c oxidase subunit 6B1 [KO:K02267]
112871161  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112853181  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112859438  cytochrome c oxidase subunit 6C [KO:K02268]
112862079  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112864047  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
112870951  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112858534  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
112868518  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112869381  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112852040  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112857044  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
112852020  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
112871754  cytochrome c oxidase assembly protein COX14 [KO:K18181]
112867605  cytochrome c oxidase assembly protein COX14 [KO:K18181]
112854545  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
112856495  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform X1 [KO:K18182]
112849485  cytochrome c oxidase copper chaperone [KO:K02260]
112858629  cytochrome c oxidase assembly protein COX18, mitochondrial [KO:K17797]
112860026  cytochrome c oxidase assembly protein COX19 [KO:K18183]
112871276  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
112866806  uncharacterized protein LOC112866806 [KO:K18173]
112854098  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
112865906  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
112869390  cytochrome c oxidase assembly factor 5 [KO:K18178]
112851563  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
112872066  cytochrome c oxidase assembly factor 7 [KO:K18180]
112868376  ATP5F1A; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
112863809  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
112867261  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
112852776  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
112851812  ATP5F1E; LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial [KO:K02135]
112849519  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
11473383  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
112869166  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112871780  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112854094  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112867188  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112864643  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
112858440  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
112862474  ATP synthase subunit f, mitochondrial-like [KO:K02130]
112858514  ATP synthase subunit f, mitochondrial-like isoform X1 [KO:K02130]
112860140  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
112849583  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
11473382  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
112862411  ATP synthase subunit g, mitochondrial [KO:K02140]
112865848  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
112863689  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
112852918  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
112851982  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
112863890  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
pcoo00020  Citrate cycle (TCA cycle)
pcoo00190  Oxidative phosphorylation
pcoo04010  MAPK signaling pathway
pcoo04022  cGMP-PKG signaling pathway
pcoo04024  cAMP signaling pathway
pcoo04150  mTOR signaling pathway
pcoo04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
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