KEGG   PATHWAY: pgut04621
Entry
pgut04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Pantherophis guttatus (corn snake)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
pgut04621  NOD-like receptor signaling pathway
pgut04621

Organism
Pantherophis guttatus (corn snake) [GN:pgut]
Gene
117656099  nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
132710190  nucleotide-binding oligomerization domain-containing protein 1-like [KO:K08727]
117668484  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
117670372  receptor-interacting serine/threonine-protein kinase 2-like isoform X1 [KO:K08846] [EC:2.7.11.1]
117675545  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117667309  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
132709271  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
117676049  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117677732  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
117665785  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
132711479  NF-kappa-B inhibitor alpha-like [KO:K04734]
117679890  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117669743  RELA; transcription factor p65 [KO:K04735]
117677036  interleukin-36 receptor antagonist protein-like isoform X1 [KO:K04519]
117673364  interleukin-1 beta-like [KO:K04519]
117658770  interleukin-36 alpha-like [KO:K04519]
117670239  interleukin-18-like [KO:K05482]
117655168  IL6; interleukin-6 [KO:K05405]
117667868  TNF; tumor necrosis factor [KO:K03156]
117665048  interleukin-8-like [KO:K10030]
117659162  C-C motif chemokine 5-like [KO:K12499]
117658026  cathelicidin-related peptide Oh-Cath-like [KO:K13916]
117660774  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117655410  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117666352  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
117669398  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X2 [KO:K12793]
117666745  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117676368  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117664553  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117655531  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117678928  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132710426  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117664010  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117664013  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117667650  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117667674  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117664293  JUN; transcription factor Jun [KO:K04448]
117678530  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
117660814  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
117674665  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
117656289  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
117671089  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
117663673  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
117670897  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
117666612  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
117671949  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
117666938  SHARPIN; sharpin isoform X1 [KO:K10630] [EC:2.3.2.31]
117657286  RNF31; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
117665131  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
117679237  ERBIN; erbin isoform X3 [KO:K12796]
117660822  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117667903  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117676633  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
117671674  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
117665476  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117671297  CARD9; caspase recruitment domain-containing protein 9 isoform X2 [KO:K12794]
117666303  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
117656958  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
117666012  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
117655703  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
117670738  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
117664473  IRF3; interferon regulatory factor 3 [KO:K05411]
117665185  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
117661924  interferon alpha-21-like [KO:K05414]
117661925  interferon tau-2-like [KO:K05414]
117661926  interferon kappa-like [KO:K05414]
132711520  interferon alpha-2-like [KO:K05414]
132711521  interferon alpha-2-like [KO:K05414]
117670255  NLRX1; NLR family member X1 [KO:K12653]
117673647  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
117666820  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
117666879  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
117667558  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
117667559  caspase-1-like [KO:K01370] [EC:3.4.22.36]
117674759  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
117657235  BCL2L1; bcl-2-like protein 1 [KO:K04570]
117667728  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
117660546  PANX1; pannexin-1 [KO:K03443]
117672210  P2RX7; P2X purinoceptor 7 [KO:K05220]
117678783  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
117675751  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
117661839  CASR; extracellular calcium-sensing receptor [KO:K04612]
117666377  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
117665693  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117674364  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117674371  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117673926  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117668319  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117663981  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117656120  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
117676153  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X2 [KO:K15040]
117676050  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
117670660  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
117661130  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
117667495  DHX33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
117678166  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
117666891  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
117672432  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
117662239  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
117655791  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
117675541  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
117675228  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
117669403  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
117671018  cytochrome b-245 light chain [KO:K08009]
117671194  thioredoxin-interacting protein [KO:K20910]
132710203  thioredoxin-interacting protein-like [KO:K20910]
117661576  thioredoxin isoform X1 [KO:K03671]
117655773  TXN2; thioredoxin, mitochondrial [KO:K03671]
117662001  thioredoxin-like [KO:K03671]
117677306  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
117665996  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
117671840  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
117667822  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
117661017  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
117665438  FADD; FAS-associated death domain protein [KO:K02373]
117667001  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20865]
117658046  LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 12-like [KO:K20865]
117679330  NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807]
117671880  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
117678118  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
117676240  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
117675384  transforming protein RhoA-like [KO:K04513]
117679240  RHOA; transforming protein RhoA [KO:K04513]
117659257  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
117677161  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
117669768  YWHAE; 14-3-3 protein epsilon [KO:K06630]
117677652  guanylate-binding protein 1-like [KO:K20899]
117675965  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
117675680  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
117674995  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
117675564  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
117672712  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
117662768  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
117656869  TLR4; toll-like receptor 4 [KO:K10160]
117668655  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
117654762  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
117660695  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
132712366  interleukin-1 receptor-associated kinase 4-like [KO:K04733] [EC:2.7.11.1]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
pgut04010  MAPK signaling pathway
pgut04140  Autophagy - animal
pgut04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

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