KEGG   PATHWAY: ppam04722
Entry
ppam04722                   Pathway                                
Name
Neurotrophin signaling pathway - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
Class
Organismal Systems; Nervous system
Pathway map
ppam04722  Neurotrophin signaling pathway
ppam04722

Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129063964  NGF; beta-nerve growth factor [KO:K02582]
129080496  BDNF; brain-derived neurotrophic factor [KO:K04355]
129082927  NTF4; neurotrophin-4 [KO:K12457]
129071284  NTF3; neurotrophin-3 [KO:K04356]
129062360  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
129078231  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
129073895  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
129083439  SH2B2; SH2B adapter protein 2 isoform X1 [KO:K07193]
129078082  SH2B1; SH2B adapter protein 1 isoform X1 [KO:K12459]
129087399  SH2B3; SH2B adapter protein 3 isoform X1 [KO:K12459]
129086587  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
129064134  son of sevenless homolog 2 isoform X1 [KO:K03099]
129066034  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
129073113  HRAS; GTPase HRas isoform X1 [KO:K02833]
129084969  KRAS; GTPase KRas isoform X1 [KO:K07827]
129063946  NRAS; GTPase NRas [KO:K07828]
129088423  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
129062984  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
129064157  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129078155  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
129078069  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129086248  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129069204  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
129076934  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
129065331  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
129088189  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
129065833  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
129077836  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129078764  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129067749  KIDINS220; kinase D-interacting substrate of 220 kDa isoform X1 [KO:K12460]
129075876  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
129070345  CRK; adapter molecule crk isoform X1 [KO:K04438]
129086337  CRKL; crk-like protein [KO:K04438]
129079197  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
129063844  RAP1A; ras-related protein Rap-1A [KO:K04353]
129075864  RAP1B; ras-related protein Rap-1b [KO:K07836]
129070196  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
129064151  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
129068690  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
129068299  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129068300  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
129067412  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129067413  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129062278  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
129062405  SHC1; SHC-transforming protein 1 [KO:K06279]
129072430  SHC2; SHC-transforming protein 2 [KO:K17447]
129082357  SHC3; SHC-transforming protein 3 [KO:K17448]
129064266  SHC4; SHC-transforming protein 4 [KO:K17449]
129062066  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
129074969  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129069407  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129074590  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129075675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129076577  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129088291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129076641  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129066231  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129073033  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129076653  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
129082066  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129067054  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
129085322  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129068571  RELA; transcription factor p65 [KO:K04735]
129067686  FOXO3; forkhead box protein O3 [KO:K09408]
129081899  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129068612  BAD; bcl2-associated agonist of cell death [KO:K02158]
129069640  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129083615  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129080305  IRS1; insulin receptor substrate 1 [KO:K16172]
129070698  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
129075160  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
129087905  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
129063259  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129082875  CALM3; calmodulin-3 [KO:K02183]
129084580  calmodulin-like [KO:K02183]
129065634  CALM2; calmodulin-2 [KO:K02183]
129065835  CALM1; calmodulin-1 [KO:K02183]
129078752  CALML6; calmodulin-like protein 6 [KO:K02183]
129086576  calmodulin-alpha-like [KO:K02183]
129087301  CALML3; calmodulin-like protein 3 [KO:K02183]
129062638  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129068934  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129069869  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129066548  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129083913  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
129079203  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
129087362  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129074279  MATK; megakaryocyte-associated tyrosine-protein kinase isoform X1 [KO:K08888] [EC:2.7.10.2]
129080218  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
129084999  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
129086466  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
129081282  ARHGDIG; rho GDP-dissociation inhibitor 3 isoform X1 [KO:K12462]
129085967  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
129087688  RHOA; transforming protein RhoA [KO:K04513]
129074464  transforming protein RhoA-like isoform X1 [KO:K04513]
129069153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129078413  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129071974  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
129067800  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129078555  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129070771  JUN; transcription factor Jun [KO:K04448]
129072290  TP53; cellular tumor antigen p53 [KO:K04451]
129082924  BAX; apoptosis regulator BAX [KO:K02159]
129078982  TP73; tumor protein p73 isoform X1 [KO:K10148]
129080456  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129066278  ZNF274; neurotrophin receptor-interacting factor homolog isoform X1 [KO:K12458]
129071348  PRDM4; PR domain zinc finger protein 4 isoform X1 [KO:K12463] [EC:2.1.1.-]
129073269  MAGED1; melanoma-associated antigen D1 [KO:K12464]
129061175  BEX3; protein BEX3 [KO:K12465]
129070343  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
129088416  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
129074364  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
129087944  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
129075857  IRAK3; interleukin-1 receptor-associated kinase 3 [KO:K04732] [EC:2.7.11.1]
129084910  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
129064790  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129063821  SORT1; sortilin isoform X1 [KO:K12388]
129065916  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
129073012  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11399424
  Authors
Patapoutian A, Reichardt LF
  Title
Trk receptors: mediators of neurotrophin action.
  Journal
Curr Opin Neurobiol 11:272-80 (2001)
DOI:10.1016/S0959-4388(00)00208-7
Reference
PMID:16699811
  Authors
Arevalo JC, Wu SH
  Title
Neurotrophin signaling: many exciting surprises!
  Journal
Cell Mol Life Sci 63:1523-37 (2006)
DOI:10.1007/s00018-006-6010-1
Reference
PMID:14704852
  Authors
Teng KK, Hempstead BL
  Title
Neurotrophins and their receptors: signaling trios in complex biological systems.
  Journal
Cell Mol Life Sci 61:35-48 (2004)
DOI:10.1007/s00018-003-3099-3
Reference
PMID:11529497
  Authors
Miller FD, Kaplan DR
  Title
Neurotrophin signalling pathways regulating neuronal apoptosis.
  Journal
Cell Mol Life Sci 58:1045-53 (2001)
DOI:10.1007/PL00000919
Reference
PMID:10851172
  Authors
Kaplan DR, Miller FD
  Title
Neurotrophin signal transduction in the nervous system.
  Journal
Curr Opin Neurobiol 10:381-91 (2000)
DOI:10.1016/S0959-4388(00)00092-1
Reference
PMID:16939974
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
Reference
PMID:16856873
  Authors
Zampieri N, Chao MV
  Title
Mechanisms of neurotrophin receptor signalling.
  Journal
Biochem Soc Trans 34:607-11 (2006)
DOI:10.1042/BST0340607
Reference
PMID:15499580
  Authors
Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A
  Title
From modulator to mediator: rapid effects of BDNF on ion channels.
  Journal
Bioessays 26:1185-94 (2004)
DOI:10.1002/bies.20118
Reference
PMID:10812966
  Authors
Yano H, Chao MV
  Title
Neurotrophin receptor structure and interactions.
  Journal
Pharm Acta Helv 74:253-60 (2000)
DOI:10.1016/s0031-6865(99)00036-9
Reference
PMID:10764727
  Authors
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA
  Title
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
  Journal
J Biol Chem 275:17566-70 (2000)
DOI:10.1074/jbc.C000140200
Reference
PMID:10985348
  Authors
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA
  Title
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
  Journal
Neuron 27:279-88 (2000)
DOI:10.1016/S0896-6273(00)00036-2
Related
pathway
ppam04010  MAPK signaling pathway
ppam04120  Ubiquitin mediated proteolysis
ppam04210  Apoptosis
ppam04720  Long-term potentiation
ppam04810  Regulation of actin cytoskeleton
KO pathway
ko04722   
LinkDB

DBGET integrated database retrieval system