KEGG   PATHWAY: psex00230
Entry
psex00230                   Pathway                                
Name
Purine metabolism - Polypterus senegalus (gray bichir)
Class
Metabolism; Nucleotide metabolism
Pathway map
psex00230  Purine metabolism
psex00230

Module
psex_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:psex00230]
psex_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:psex00230]
psex_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:psex00230]
psex_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:psex00230]
psex_M00546  Purine degradation, xanthine => urea [PATH:psex00230]
psex_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:psex00230]
psex_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:psex00230]
Other DBs
GO: 0006163 0042278
Organism
Polypterus senegalus (gray bichir) [GN:psex]
Gene
120536559  ADP-ribose pyrophosphatase, mitochondrial-like [KO:K13988] [EC:3.6.1.13]
120517834  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120534052  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
120515254  pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
120527644  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
120522879  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
120537152  ribose-phosphate pyrophosphokinase 2-like isoform X1 [KO:K00948] [EC:2.7.6.1]
120537154  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
120537157  ribose-phosphate pyrophosphokinase 2-like isoform X1 [KO:K00948] [EC:2.7.6.1]
120527462  ppat; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
120522674  gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120515251  pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
120527461  paics; multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120536786  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
120522447  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120535426  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
120538969  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
120514395  cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
120525671  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
120516502  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
120543025  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
120517167  5'(3')-deoxyribonucleotidase, cytosolic type-like [KO:K01081] [EC:3.1.3.5]
120517477  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
120525619  nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
120523520  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120514616  pnp4a; purine nucleoside phosphorylase 4a [KO:K03783] [EC:2.4.2.1]
120516006  pnp4b; purine nucleoside phosphorylase 4b [KO:K03783] [EC:2.4.2.1]
120535312  pnp6; purine nucleoside phosphorylase 6 [KO:K03783] [EC:2.4.2.1]
120523714  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
120535470  hprt1l; hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
120537331  hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
120534129  impdh1a; inosine-5'-monophosphate dehydrogenase 1a isoform X1 [KO:K00088] [EC:1.1.1.205]
120523662  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120525987  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
120542276  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
120517171  nucleoside diphosphate kinase A 2 [KO:K00940] [EC:2.7.4.6]
120543227  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
120525536  ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
120519578  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120516044  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
120542106  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120543195  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120518201  cant1b; soluble calcium-activated nucleotidase 1b [KO:K12304] [EC:3.6.1.6]
120538917  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
120516277  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
120518790  entpd5a; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
120542304  zgc:103759; U8 snoRNA-decapping enzyme isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
120542590  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
120515138  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
120525729  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120532829  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
120531716  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
120525540  GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
120516475  gmpr; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
120527378  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
120523951  rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
120526045  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120517860  ribonucleoside-diphosphate reductase subunit M2-like isoform X1 [KO:K10808] [EC:1.17.4.1]
120536949  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
120525799  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
120538872  deoxycytidine kinase 2-like [KO:K00904] [EC:2.7.1.113]
120532514  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120543118  deoxycytidine kinase 2-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120540515  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1-like [KO:K21138] [EC:3.1.7.2]
120527238  prune; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
120529518  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
120515751  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
120526110  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
120524043  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
120530718  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120524822  adcy6a; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
120535204  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120529809  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120543008  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120523165  gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
120527161  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
120524430  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
120527162  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
120527311  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120536907  gucy2ca; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
120526471  retinal guanylyl cyclase 2-like [KO:K12321] [EC:4.6.1.2]
120524406  gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
120515354  gucy2g; guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
120538223  atrial natriuretic peptide receptor 1-like isoform X1 [KO:K12323] [EC:4.6.1.2]
120514322  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
120532065  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
120532921  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
120542726  soluble guanylate cyclase 88E-like [KO:K01769] [EC:4.6.1.2]
120527355  soluble guanylate cyclase 88E-like [KO:K01769] [EC:4.6.1.2]
120531902  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120524929  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120529404  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120523931  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
120539567  pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
120516860  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
120533085  pde5ab; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
120542403  pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
120527218  pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
120540993  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
120532492  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
120542626  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
120536224  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma-like [KO:K13760]
120530497  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
120535967  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like isoform X1 [KO:K13761] [EC:3.1.4.35]
120516310  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
120531887  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120533778  adenylosuccinate synthetase isozyme 2-like isoform X1 [KO:K01939] [EC:6.3.4.4]
120516355  adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
120525897  ampd2b; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120526282  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
120535743  AMP deaminase 3-like isoform X1 [KO:K01490] [EC:3.5.4.6]
120541666  adenosine kinase-like isoform X1 [KO:K00856] [EC:2.7.1.20]
120514237  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
120518869  adenylate kinase 7-like [KO:K00939] [EC:2.7.4.3]
120523787  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
120540025  adenylate kinase isoenzyme 5-like isoform X1 [KO:K00939] [EC:2.7.4.3]
120514195  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
120514569  ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
120535088  adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
120517314  ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120536015  ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
120527415  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
120542164  ectonucleoside triphosphate diphosphohydrolase 2-like isoform X1 [KO:K01509] [EC:3.6.1.-]
120516744  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
120515508  venom phosphodiesterase 2-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120516230  ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120537925  pde4ca; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120514260  pde4ba; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
120532593  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120541232  pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
120530259  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
120516303  cAMP-specific 3',5'-cyclic phosphodiesterase 7B-like isoform X1 [KO:K18436] [EC:3.1.4.53]
120532423  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
120541309  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
120541090  fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
120526316  enpp4; bis(5'-adenosyl)-triphosphatase enpp4 [KO:K18424] [EC:3.6.1.29]
120532816  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120515285  uox; uricase [KO:K00365] [EC:1.7.3.3]
120535621  urahb; 5-hydroxyisourate hydrolase b [KO:K07127] [EC:3.5.2.17]
120523845  urad; 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
120534883  zgc:103559 [KO:K01466] [EC:3.5.2.5]
120526021  allc; allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
psex00030  Pentose phosphate pathway
psex00220  Arginine biosynthesis
psex00250  Alanine, aspartate and glutamate metabolism
psex00260  Glycine, serine and threonine metabolism
psex00340  Histidine metabolism
psex00630  Glyoxylate and dicarboxylate metabolism
psex00730  Thiamine metabolism
psex00740  Riboflavin metabolism
psex00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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