KEGG   PATHWAY: pteh05203
Entry
pteh05203                   Pathway                                
Name
Viral carcinogenesis - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
pteh05203  Viral carcinogenesis
pteh05203

Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111553268  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111540622  KRAS; GTPase KRas isoform X1 [KO:K07827]
111549619  NRAS; GTPase NRas [KO:K07828]
111530673  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111525729  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
111547676  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111542753  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111548140  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111548991  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111521981  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
111543707  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
111544982  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111536760  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111524755  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
111551841  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
111528965  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
111524303  DDB1; DNA damage-binding protein 1 [KO:K10610]
111520900  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
111531828  YWHAQ; 14-3-3 protein theta [KO:K16197]
111553214  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
111530644  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
111521815  YWHAH; 14-3-3 protein eta [KO:K16198]
113219724  14-3-3 protein eta [KO:K16198]
111547068  YWHAG; 14-3-3 protein gamma [KO:K16198]
111541367  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
111537369  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111537370  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
111537374  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
111551382  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
111548479  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113219585  serine protease hepsin-like [KO:K08665] [EC:3.4.21.106]
111521403  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111544647  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111523340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111554247  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111539891  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111548774  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111522422  RELA; transcription factor p65 isoform X1 [KO:K04735]
111553469  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
111538840  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111547971  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111527100  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
111553938  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111549709  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
111541872  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111537959  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
111545695  EGR3; early growth response protein 3 [KO:K12497]
111544092  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111555938  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159]
111527513  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
111529518  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
111542983  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111536344  DDX3X; ATP-dependent RNA helicase DDX3X isoform X1 [KO:K11594] [EC:5.6.2.7]
111545386  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
111523821  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111543418  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
111540404  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111541026  histone H2B type 1 [KO:K11252]
111541031  histone H2B type 1-A [KO:K11252]
111541068  histone H2B type 1-M-like [KO:K11252]
111541074  histone H2B type 1 [KO:K11252]
111541075  histone H2B type 1 [KO:K11252]
111541076  histone H2B type 1-F/J/L-like [KO:K11252]
111541077  histone H2B type 1 [KO:K11252]
111541078  histone H2B type 2-F-like [KO:K11252]
111541079  histone H2B type 1-B [KO:K11252]
111551458  late histone H2B.L4 [KO:K11252]
111532193  histone H2B type F-M [KO:K11252]
111543592  histone H2B type 2-F isoform X2 [KO:K11252]
111543593  histone H2B type 2-E [KO:K11252]
116418733  histone H2B type 3-B [KO:K11252]
113222237  histone H2B type F-M [KO:K11252]
111536553  histone H2B type W-T-like [KO:K11252]
111525943  histone H2B type 1-K [KO:K11252]
111525949  histone H2B type 1-J [KO:K11252]
111525952  histone H2B type 1-M [KO:K11252]
111525976  histone H2B type 1-F/J/L [KO:K11252]
111525979  histone H2B type 1-O [KO:K11252]
111525987  histone H2B type 1-N [KO:K11252]
111530702  histone H2B type W-T [KO:K11252]
113222492  histone H2B type W-T-like [KO:K11252]
111525944  histone H4 [KO:K11254]
111528598  histone H4 isoform X2 [KO:K11254]
111541081  histone H4 [KO:K11254]
111541082  histone H4 [KO:K11254]
111552129  histone H4 [KO:K11254]
113219622  histone H4 [KO:K11254]
113221881  histone H4 [KO:K11254]
111520083  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111542428  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111541333  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
111521941  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111530912  TBP; TATA-box-binding protein [KO:K03120]
111554913  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
111555251  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
111551658  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
111528609  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113219544  RBPJ; recombining binding protein suppressor of hairless [KO:K06053]
111553280  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
111521554  SNW1; SNW domain-containing protein 1 isoform X1 [KO:K06063]
111555008  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
111539902  general transcription factor IIH subunit 2 isoform X1 [KO:K03142]
111538561  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
111527887  GTF2H4; general transcription factor IIH subunit 4 [KO:K03144]
111543990  GTF2E1; general transcription factor IIE subunit 1 [KO:K03136]
111544155  GTF2E2; transcription initiation factor IIE subunit beta [KO:K03137]
111550152  SND1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
111551734  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
111548964  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
111540086  GTF2B; transcription initiation factor IIB isoform X1 [KO:K03124]
111522272  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111535839  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111543039  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111552475  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111546231  CCNA2; cyclin-A2 [KO:K06627]
111540405  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
111545519  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
111527881  MRPS18B; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
111550331  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
111553030  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111538162  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111531090  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
111554242  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
111524867  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
111528531  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111541349  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
111549714  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
111525102  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
111523601  SCRIB; protein scribble homolog isoform X7 [KO:K16175]
111537633  paxillin isoform X1 [KO:K05760]
111542928  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
111519959  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
111538209  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
111523077  RB1; retinoblastoma-associated protein [KO:K06618]
111553239  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
111541247  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
111552085  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
111547759  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
111523160  JUN; transcription factor AP-1 [KO:K04448]
111555888  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
111547314  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
111547559  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
111526964  HDAC3; histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
111553726  HDAC4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
111525826  HDAC5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
111535713  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
111555299  HDAC7; histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
111535879  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
111545038  HDAC9; histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
111548884  HDAC10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
111529310  HDAC11; histone deacetylase 11 isoform X1 [KO:K11418] [EC:3.5.1.98]
111548313  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
111552934  IRF9; interferon regulatory factor 9 [KO:K04693]
111551705  DNAJA3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
111537379  KAT2A; histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
111539476  KAT2B; histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
111550408  GTF2A1L; TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
111521648  GTF2A1; transcription initiation factor IIA subunit 1 [KO:K03122]
111553643  GTF2A2; transcription initiation factor IIA subunit 2 [KO:K03123]
111543068  SRF; serum response factor [KO:K04378]
111524454  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
111526428  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
111547718  CDC42; cell division control protein 42 homolog [KO:K04393]
111530500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111555593  RHOA; transforming protein RhoA [KO:K04513]
111550325  GSN; gelsolin isoform X1 [KO:K05768]
111551642  SCIN; adseverin [KO:K05768]
111520112  ACTN1; alpha-actinin-1 [KO:K05699]
111554064  ACTN4; alpha-actinin-4 [KO:K05699]
111541790  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111537212  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
111540298  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
111548724  CDC20; cell division cycle protein 20 homolog [KO:K03363]
111541438  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
111550431  ran-specific GTPase-activating protein-like [KO:K15306]
111526742  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
111527699  POLB; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
111520580  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
111541627  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
111555364  CCR5; C-C chemokine receptor type 5 [KO:K04180]
111555573  CCR8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
111555470  CCR3; C-C chemokine receptor type 3 isoform X1 [KO:K04178]
111544240  CCR4; C-C chemokine receptor type 4 [KO:K04179]
111522809  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
111547169  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111522294  BAD; bcl2-associated agonist of cell death [KO:K02158]
111546851  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
111522637  C3; complement C3 [KO:K03990]
111532532  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
111532737  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain [KO:K06751]
111533914  patr class I histocompatibility antigen, A-126 alpha chain isoform X1 [KO:K06751]
111527873  uncharacterized protein LOC111527873 [KO:K06751]
111525936  mamu class I histocompatibility antigen, alpha chain F [KO:K06751]
111527830  patr class I histocompatibility antigen, alpha chain E [KO:K06751]
111534256  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
113220632  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
111534983  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
111531230  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
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Biochim Biophys Acta 1782:127-50 (2008)
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Reference
PMID:21102637
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Moore PS, Chang Y
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Why do viruses cause cancer? Highlights of the first century of human tumour virology.
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Nat Rev Cancer 10:878-89 (2010)
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PMID:19400863
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APMIS 117:382-99 (2009)
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PMID:17979705
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  Title
Viral origins of human cancer.
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Curr Med Chem 14:2526-39 (2007)
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PMID:21084867
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  Title
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Cancer Biol Ther 10:961-78 (2010)
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PMID:21152115
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Zheng ZM
  Title
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Int J Biol Sci 6:730-55 (2010)
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PMID:19956178
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Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
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Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
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PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
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J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
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Virus Res 92:131-40 (2003)
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Reference
PMID:21647825
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  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
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J Gastroenterol 46:974-90 (2011)
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Reference
PMID:21966251
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  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
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Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
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Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
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Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Reference
PMID:16039586
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Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
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J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
pteh03022  Basal transcription factors
pteh03320  PPAR signaling pathway
pteh04010  MAPK signaling pathway
pteh04062  Chemokine signaling pathway
pteh04064  NF-kappa B signaling pathway
pteh04110  Cell cycle
pteh04115  p53 signaling pathway
pteh04142  Lysosome
pteh04151  PI3K-Akt signaling pathway
pteh04210  Apoptosis
pteh04630  JAK-STAT signaling pathway
pteh04662  B cell receptor signaling pathway
pteh04810  Regulation of actin cytoskeleton
pteh05160  Hepatitis C
pteh05161  Hepatitis B
pteh05165  Human papillomavirus infection
pteh05166  Human T-cell leukemia virus 1 infection
pteh05167  Kaposi sarcoma-associated herpesvirus infection
pteh05169  Epstein-Barr virus infection
KO pathway
ko05203   
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