KEGG   PATHWAY: ptex04142
Entry
ptex04142                   Pathway                                
Name
Lysosome - Pseudonaja textilis (eastern brown snake)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
ptex04142  Lysosome
ptex04142

Other DBs
GO: 0005764
Organism
Pseudonaja textilis (eastern brown snake) [GN:ptex]
Gene
113435385  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
113441116  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
113442965  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
113448604  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
113439850  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
113445256  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
113435428  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
113445083  V-type proton ATPase subunit S1-like [KO:K03662]
113443276  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
113438700  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
113440562  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
113442365  DMXL2; dmX-like protein 2 [KO:K24155]
113449281  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
113445883  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
113439569  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
113450546  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
113446348  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
113440429  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
113440288  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
113443726  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
113446101  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
113435697  cathepsin E-like [KO:K01382] [EC:3.4.23.34]
113447492  CTSF; cathepsin F [KO:K01373] [EC:3.4.22.41]
113442050  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
113449215  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
113450339  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
113450340  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
113450356  LOW QUALITY PROTEIN: cathepsin K-like [KO:K01365] [EC:3.4.22.15]
113454069  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
113438490  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
113435949  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
113449184  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
113446680  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
113434323  CTSZ; cathepsin Z isoform X1 [KO:K08568] [EC:3.4.18.1]
113444482  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
113450417  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
113437806  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
113448130  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
113437036  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
113438821  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
113446653  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
113453028  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
113453029  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
113454157  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
113454462  glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
113444136  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
113434142  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
113438874  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
113442876  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
113438765  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
113441562  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
113439660  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
113437562  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
113444992  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
113442261  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
113434818  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
113433620  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
113449085  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
113445100  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
113445101  LOW QUALITY PROTEIN: hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
113454058  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
113454077  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
113454094  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
113449825  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
113451586  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
113447495  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
113443162  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
113448913  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
113445820  N-acetylglucosamine-6-sulfatase-like [KO:K01137] [EC:3.1.6.14]
113435974  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
113446801  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
113437035  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
113442740  putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
113442759  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
113442775  LOW QUALITY PROTEIN: putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
113449030  lipase member K-like isoform X1 [KO:K01052] [EC:3.1.1.13]
113445112  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
113446931  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
113441119  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
113446913  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
113450462  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
113434659  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
113435702  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
113444702  prosaposin-like [KO:K12382]
113444712  PSAP; prosaposin isoform X1 [KO:K12382]
113433825  GM2A; ganglioside GM2 activator [KO:K12383]
113437572  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
113449094  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
113440760  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
113453237  lysosome-associated membrane glycoprotein 2-like [KO:K06528]
113453238  lysosome-associated membrane glycoprotein 2-like [KO:K06528]
113451683  CD68; macrosialin [KO:K06501]
113441072  tetraspanin-6-like [KO:K06497]
113443133  CD63; CD63 antigen [KO:K06497]
113447114  SCARB2; lysosome membrane protein 2 [KO:K12384]
113435474  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
113443467  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
113442523  CTNS; cystinosin [KO:K12386]
113432894  SLC17A5; sialin isoform X1 [KO:K12301]
113441171  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
113445571  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
113439885  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
113433003  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
113443858  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
113448692  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
113455334  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
113445602  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
113445656  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
113446976  sortilin-like [KO:K12388]
113447771  sortilin-like [KO:K12388]
113443704  CLN3; battenin isoform X1 [KO:K12389]
113439431  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
113434711  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
113448259  major facilitator superfamily domain-containing protein 8-like [KO:K12307]
113447279  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
113451162  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
113454715  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
113438595  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
113438651  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
113439285  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
113444485  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
113444131  CLTA; clathrin light chain A isoform X1 [KO:K04644]
113433868  CLTB; clathrin light chain B [KO:K04645]
113446507  clathrin heavy chain 1-like isoform X1 [KO:K04646]
113442509  CLTC; clathrin heavy chain 1 [KO:K04646]
113448733  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
113448944  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
113450879  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
113435176  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
113446866  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
113445161  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
113452110  AP-1 complex subunit sigma-1A-like [KO:K12394]
113452115  AP-1 complex subunit sigma-1A-like [KO:K12394]
113452131  AP-1 complex subunit sigma-1A-like [KO:K12394]
113452137  AP-1 complex subunit sigma-1A-like [KO:K12394]
113453552  AP-1 complex subunit sigma-1A-like [KO:K12394]
113453554  AP-1 complex subunit sigma-1A-like [KO:K12394]
113436849  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
113435271  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
113447474  AP3B1; AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
113442286  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
113445823  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
113452613  AP-3 complex subunit mu-1 [KO:K12398]
113452615  AP-3 complex subunit mu-1 [KO:K12398]
113449185  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
113442366  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
113444279  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
113450548  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
113442912  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
113433357  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
113437132  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
113446878  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
113438875  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
ptex00511  Other glycan degradation
ptex00531  Glycosaminoglycan degradation
ptex04130  SNARE interactions in vesicular transport
ptex04140  Autophagy - animal
ptex04144  Endocytosis
KO pathway
ko04142   
LinkDB

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