KEGG   PATHWAY: ptg05170
Entry
ptg05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Panthera tigris altaica (Amur tiger)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
ptg05170  Human immunodeficiency virus 1 infection
ptg05170

Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102954103  CD4; CD4 molecule [KO:K06454]
102962015  FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
102953972  BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
102957702  SKP1; S-phase kinase associated protein 1 [KO:K03094]
102957061  CUL1; cullin 1 [KO:K03347]
102955881  RBX1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
102955333  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
102950303  CCR5; C-C chemokine receptor type 5 [KO:K04180]
102954501  GNAI1; G protein subunit alpha i1 [KO:K04630]
102951159  GNAI3; G protein subunit alpha i3 [KO:K04630]
102962946  GNAI2; G protein subunit alpha i2 [KO:K04630]
102958483  GNAO1; G protein subunit alpha o1 [KO:K04534]
102953082  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102965070  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102972487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102949853  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102952993  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102967709  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102953254  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102955963  PTK2B; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
102953161  PXN; paxillin [KO:K05760]
102957241  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102956621  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102952603  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102954757  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102967196  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102950850  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102960736  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102964232  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102951132  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102952769  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102958666  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102956027  BAD; BCL2 associated agonist of cell death [KO:K02158]
102952119  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102957350  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102952980  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102955852  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102969757  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102956808  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102964841  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102960964  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102954227  GNAQ; G protein subunit alpha q [KO:K04634]
107181018  GNA11; G protein subunit alpha 11 [KO:K04635]
102952137  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102963653  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102963245  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102971840  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102967639  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102953457  CALM3; calmodulin 3 [KO:K02183]
102963939  calmodulin-like [KO:K02183]
102964234  CALML3; calmodulin-like protein 3 [KO:K02183]
102954552  CALM2; calmodulin 2 [KO:K02183]
102960923  calmodulin-like [KO:K02183]
102950842  CALML6; calmodulin like 6 [KO:K02183]
102951822  CALM1; calmodulin 1 [KO:K02183]
102971520  calmodulin-alpha-like [KO:K02183]
102950182  CALML4; calmodulin like 4 [KO:K02183]
102952632  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102949359  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102963447  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102965200  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102967427  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102969678  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
102972106  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102956831  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
102968590  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102952814  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102956490  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102950533  GNB1; G protein subunit beta 1 [KO:K04536]
102955271  GNB2; G protein subunit beta 2 [KO:K04537]
102953535  GNB3; G protein subunit beta 3 [KO:K07825]
102963895  GNB4; G protein subunit beta 4 [KO:K04538]
102954935  GNB5; G protein subunit beta 5 [KO:K04539]
102962902  GNG2; G protein subunit gamma 2 [KO:K07826]
102968307  GNG3; G protein subunit gamma 3 [KO:K04540]
102953604  GNG4; G protein subunit gamma 4 [KO:K04541]
102963799  GNG7; G protein subunit gamma 7 [KO:K04543]
102956095  GNG10; G protein subunit gamma 10 [KO:K04545]
102972135  GNG11; G protein subunit gamma 11 [KO:K04546]
102951416  GNG12; G protein subunit gamma 12 [KO:K04347]
102949358  GNG13; G protein subunit gamma 13 [KO:K04547]
102972425  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
102967045  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
102968561  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102961922  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102955504  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102963927  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102968498  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102960506  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102950254  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
102959873  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102972937  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102966775  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102952158  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
102959514  CFL2; cofilin 2 [KO:K05765]
102970553  CFL1; cofilin 1 [KO:K05765]
102958919  TNF; tumor necrosis factor [KO:K03156]
102971882  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
102950221  BCL2L1; BCL2 like 1 [KO:K04570]
102962241  toll-like receptor 2 [KO:K10159]
102964242  toll-like receptor 2 [KO:K10159]
102959529  TLR4; toll like receptor 4 [KO:K10160]
102952059  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102962570  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102960157  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102950874  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102959790  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102963341  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102949289  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102963734  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102956127  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102956750  interferon alpha-2-like [KO:K05414]
102960421  IFNB1; interferon beta 1 [KO:K05415]
102968191  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102960306  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102960590  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102968482  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102959159  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102950880  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102963096  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102952381  MB21D1; Mab-21 domain containing 1 [KO:K17834] [EC:2.7.7.86]
102949177  TMEM173; transmembrane protein 173 [KO:K12654]
102960158  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102956602  IRF3; interferon regulatory factor 3 [KO:K05411]
102971284  DNA dC->dU-editing enzyme APOBEC-3-like [KO:K18750] [EC:3.5.4.-]
102967282  SAMHD1; SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [KO:K22544] [EC:3.1.5.-]
102971923  TRIM34; tripartite motif-containing protein 34 [KO:K10648] [EC:2.3.2.27]
102955435  BST2; bone marrow stromal cell antigen 2 [KO:K06731]
102956793  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102964459  RIPK1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
102968597  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102972430  TRAF5; TNF receptor associated factor 5 [KO:K09849]
102966802  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102949954  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102966485  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102949140  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102953222  FASLG; Fas ligand [KO:K04389]
102958442  FAS; Fas cell surface death receptor [KO:K04390]
102962460  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102951809  BID; BH3 interacting domain death agonist [KO:K04726]
102949153  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102970767  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102953487  BCL2; BCL2, apoptosis regulator [KO:K02161]
102966744  cytochrome c 2-like [KO:K08738]
102952864  cytochrome c-like [KO:K08738]
102960081  cytochrome c [KO:K08738]
102967404  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102954729  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102969557  CD3E; CD3e molecule [KO:K06451]
102968170  CD3G; CD3g molecule [KO:K06452]
102969057  CD3D; CD3d molecule [KO:K06450]
102948605  CD247; CD247 molecule [KO:K06453]
102969103  TAP1; transporter 1, ATP binding cassette subfamily B member [KO:K05653] [EC:7.4.2.14]
102958303  TAP2; transporter 2, ATP binding cassette subfamily B member [KO:K05654] [EC:7.4.2.14]
102949355  TAPBP; TAP binding protein [KO:K08058]
102966352  PDIA3; protein disulfide isomerase family A member 3 [KO:K08056] [EC:5.3.4.1]
102964419  CALR; calreticulin [KO:K08057]
102959211  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
102970351  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
102970631  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102958279  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
102965588  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
102965871  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
102961195  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
102962351  AP1B1; adaptor related protein complex 1 beta 1 subunit [KO:K12392]
102949836  AP1G1; adaptor related protein complex 1 gamma 1 subunit [KO:K12391]
102950562  AP1G2; adaptor related protein complex 1 gamma 2 subunit [KO:K12391]
102952048  AP1M2; adaptor related protein complex 1 mu 2 subunit [KO:K12393]
102959967  AP1M1; adaptor related protein complex 1 mu 1 subunit [KO:K12393]
102972027  AP1S1; adaptor related protein complex 1 sigma 1 subunit [KO:K12394]
102966106  AP1S2; adaptor related protein complex 1 sigma 2 subunit [KO:K12394]
102961683  AP1S3; adaptor related protein complex 1 sigma 3 subunit [KO:K12395]
102951857  B2M; beta-2-microglobulin [KO:K08055]
102962424  ELOB; elongin B [KO:K03873]
102959091  ELOC; elongin C [KO:K03872]
102959496  transcription elongation factor B polypeptide 1-like [KO:K03872]
102960231  CUL5; cullin 5 [KO:K10612]
107180020  RNF7; ring finger protein 7 [KO:K10611]
102955520  DCAF1; DDB1 and CUL4 associated factor 1 [KO:K11789] [EC:2.7.11.1]
102969790  DDB1; damage specific DNA binding protein 1 [KO:K10610]
102949451  CUL4A; cullin 4A [KO:K10609]
102951752  cullin-4B-like [KO:K10609]
102965558  CUL4B; cullin 4B [KO:K10609]
102958898  ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
102972858  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
102948766  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
102968740  CDC25C; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
102956091  WEE1; WEE1 G2 checkpoint kinase [KO:K06632] [EC:2.7.11.1]
102965997  WEE2; WEE1 homolog 2 [KO:K06632] [EC:2.7.11.1]
102952704  CCNB1; cyclin B1 [KO:K05868]
102951958  CCNB2; cyclin B2 [KO:K21770]
102969495  CCNB3; cyclin B3 [KO:K21771]
102971079  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
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Choi WT, Duggineni S, Xu Y, Huang Z, An J
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Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
PMID:24822052
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
PMID:22090097
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
PMID:26056579
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
PMID:20672047
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
PMID:26628325
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
PMID:25988887
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
PMID:28358311
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
PMID:18178131
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
DOI:10.1016/j.it.2007.10.008
Reference
PMID:24453421
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
PMID:23986795
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
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Reference
PMID:21368875
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
DOI:10.1038/cddis.2010.77
Reference
PMID:12766761
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
Reference
PMID:21994747
  Authors
Fevrier M, Dorgham K, Rebollo A
  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
  Journal
Viruses 3:586-612 (2011)
DOI:10.3390/v3050586
Reference
PMID:11237054
  Authors
Ross TM
  Title
Using death to one's advantage: HIV modulation of apoptosis.
  Journal
Leukemia 15:332-41 (2001)
DOI:10.1038/sj.leu.2402028
Reference
PMID:22767237
  Authors
Hurley JH, Bonifacino JS
  Title
Nef-arious goings-on at the Golgi.
  Journal
Nat Struct Mol Biol 19:661-2 (2012)
DOI:10.1038/nsmb.2304
Reference
PMID:21762823
  Authors
Wonderlich ER, Leonard JA, Collins KL
  Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
  Journal
Adv Virus Res 80:103-27 (2011)
DOI:10.1016/B978-0-12-385987-7.00005-1
Reference
PMID:20594957
  Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
  Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
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Mol Aspects Med 31:418-33 (2010)
DOI:10.1016/j.mam.2010.05.003
Reference
PMID:27161574
  Authors
Pereira EA, daSilva LL
  Title
HIV-1 Nef: Taking Control of Protein Trafficking.
  Journal
Traffic 17:976-96 (2016)
DOI:10.1111/tra.12412
Reference
PMID:26950141
  Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
  Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
  Journal
Viruses 8:67 (2016)
DOI:10.3390/v8030067
Reference
PMID:24906315
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Bagga S, Bouchard MJ
  Title
Cell cycle regulation during viral infection.
  Journal
Methods Mol Biol 1170:165-227 (2014)
DOI:10.1007/978-1-4939-0888-2_10
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PMID:15638722
  Authors
Andersen JL, Planelles V
  Title
The role of Vpr in HIV-1 pathogenesis.
  Journal
Curr HIV Res 3:43-51 (2005)
DOI:10.2174/1570162052772988
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PMID:17140287
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Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
  Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
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PLoS Pathog 2:e127 (2006)
DOI:10.1371/journal.ppat.0020127
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PMID:23430691
  Authors
Takaori-Kondo A, Shindo K
  Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
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Front Microbiol 4:34 (2013)
DOI:10.3389/fmicb.2013.00034
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PMID:19038776
  Authors
Malim MH
  Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
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Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
DOI:10.1098/rstb.2008.0185
Reference
PMID:21835787
  Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
  Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
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J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
ptg03050  Proteasome
ptg04010  MAPK signaling pathway
ptg04020  Calcium signaling pathway
ptg04064  NF-kappa B signaling pathway
ptg04110  Cell cycle
ptg04141  Protein processing in endoplasmic reticulum
ptg04142  Lysosome
ptg04150  mTOR signaling pathway
ptg04151  PI3K-Akt signaling pathway
ptg04210  Apoptosis
ptg04612  Antigen processing and presentation
ptg04620  Toll-like receptor signaling pathway
ptg04623  Cytosolic DNA-sensing pathway
ptg04668  TNF signaling pathway
ptg04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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