KEGG   PATHWAY: puc00230
Entry
puc00230                    Pathway                                
Name
Purine metabolism - Panthera uncia (snow leopard)
Class
Metabolism; Nucleotide metabolism
Pathway map
puc00230  Purine metabolism
puc00230

Module
puc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:puc00230]
puc_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:puc00230]
puc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:puc00230]
puc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:puc00230]
puc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:puc00230]
puc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:puc00230]
puc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:puc00230]
Other DBs
GO: 0006163 0042278
Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125922907  ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
125926979  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
125919987  ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
125912535  phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
125922703  phosphopentomutase isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
125930824  ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
125931477  ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
125932232  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
125922746  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
125921703  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
125927007  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
125922747  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
125920357  adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
125911223  bifunctional purine biosynthesis protein ATIC isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
125916549  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
125937434  LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
125937644  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
125932923  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
125926382  5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
125927551  5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
125912731  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
125938675  5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
125909739  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
125934128  purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
125932306  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
125921336  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
125929326  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
125930890  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
125930677  nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
125925119  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
125926717  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
125926718  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
125927156  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
125928392  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
125938789  adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
125923918  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
125932830  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
125921406  ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
125923345  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
125908693  nucleoside diphosphate phosphatase ENTPD5 isoform X1 [KO:K01511] [EC:3.6.1.6]
125936182  ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
125922005  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
125936146  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
125917080  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125918926  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
125921223  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
125939429  GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
125909652  GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
125933805  guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
125934809  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
125937019  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
125937690  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
125924777  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
125938886  5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
125937116  deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
125922797  deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
125910749  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
125912111  exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
125930396  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125934726  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125937626  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125909634  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
125921018  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125919005  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125915408  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125924401  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125926198  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125938268  LOW QUALITY PROTEIN: adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
125925887  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
125929792  guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
125923766  guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
125923768  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
125918864  guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
125929388  guanylate cyclase D-like [KO:K12321] [EC:4.6.1.2]
125927016  retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
125931895  retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
125933162  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
125925762  atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
125919466  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
125930035  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
125911509  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
125919154  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
125918200  cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
125918201  cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
125920132  LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
125923069  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
125934566  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
125922530  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
125933394  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
125911077  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
125926257  LOW QUALITY PROTEIN: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
125920397  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
125920693  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
125939043  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
125911810  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
125909104  adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
125925080  adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
125912220  LOW QUALITY PROTEIN: AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
125912289  LOW QUALITY PROTEIN: AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
125936201  AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
125933301  adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
125936571  adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
125920050  adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
125913428  adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
125921538  adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
125909071  adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
125927868  adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
125912492  adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
125912803  adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
125935717  adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
125932002  GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
125935132  LOW QUALITY PROTEIN: GTP:AMP phosphotransferase AK3, mitochondrial-like [KO:K00944] [EC:2.7.4.10]
125923632  ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
125932609  cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
125938915  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
125938916  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
125913411  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
125930540  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
125934918  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
125929242  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
125938933  cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
125924649  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
125910739  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
125935769  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
125929536  bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
125937886  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
125933182  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
125912460  uricase [KO:K00365] [EC:1.7.3.3]
125916630  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
125934076  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
125937713  probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
puc00030  Pentose phosphate pathway
puc00220  Arginine biosynthesis
puc00250  Alanine, aspartate and glutamate metabolism
puc00260  Glycine, serine and threonine metabolism
puc00340  Histidine metabolism
puc00630  Glyoxylate and dicarboxylate metabolism
puc00730  Thiamine metabolism
puc00740  Riboflavin metabolism
puc00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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