KEGG   PATHWAY: puc05162
Entry
puc05162                    Pathway                                
Name
Measles - Panthera uncia (snow leopard)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
puc05162  Measles
puc05162

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125925801  membrane cofactor protein [KO:K04007]
125931712  moesin [KO:K05763]
125925597  signaling lymphocytic activation molecule [KO:K06536]
125928971  CD209 antigen [KO:K06563]
125918656  antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
125911583  interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
125936139  mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
125909139  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
125925487  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125919296  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
125915966  interferon regulatory factor 3 isoform X1 [KO:K05411]
125932873  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125923306  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125932096  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125915462  NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
125911398  LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta-like [KO:K02581]
125909567  NF-kappa-B inhibitor alpha [KO:K04734]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125912163  transcription factor p65 [KO:K04735]
125931478  toll-like receptor 7 [KO:K05404]
125929434  toll-like receptor 9 [KO:K10161]
125921434  myeloid differentiation primary response protein MyD88 [KO:K04729]
125932080  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
125918985  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125937759  interferon regulatory factor 7 isoform X1 [KO:K09447]
125925935  interferon beta-like [KO:K05414]
125925953  interferon alpha-2-like [KO:K05414]
125925944  interferon beta [KO:K05415]
125923764  toll-like receptor 2 [KO:K10159]
125920696  toll-like receptor 4 isoform X1 [KO:K10160]
125934537  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125916946  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
125916975  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
125936726  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
125938448  casein kinase II subunit beta isoform X1 [KO:K03115]
125938952  tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
125938695  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125938017  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
125916877  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
125917114  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
125933328  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125935352  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125912547  transcription factor Jun [KO:K04448]
125909334  protein c-Fos [KO:K04379]
125937435  interleukin-1 alpha isoform X1 [KO:K04383]
125937410  interleukin-1 beta isoform X1 [KO:K04519]
125930836  interleukin-6 [KO:K05405]
125921200  interleukin-12 subunit alpha [KO:K05406]
125934482  interleukin-12 subunit beta [KO:K05425]
125921711  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
125921705  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
125934811  receptor of activated protein C kinase 1 [KO:K14753]
125913423  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125930538  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
125911435  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
125920249  signal transducer and activator of transcription 2 [KO:K11221]
125909651  interferon regulatory factor 9 [KO:K04693]
125914169  2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
125914170  2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
125914171  2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
125925735  double-stranded RNA-specific adenosine deaminase isoform X1 [KO:K12968] [EC:3.5.4.37]
125920699  interferon-induced GTP-binding protein Mx1 [KO:K14754]
125928282  eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
125937286  interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
125937418  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
125909837  eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
125931483  ras-related protein Rab-9A isoform X1 [KO:K07899]
125931875  ras-related protein Rab-9B [KO:K07900]
125938430  heat shock 70 kDa protein 1-like [KO:K03283]
125908763  heat shock cognate 71 kDa protein [KO:K03283]
125925195  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
125917444  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
125918428  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
125924465  eukaryotic translation initiation factor 3 subunit H isoform X1 [KO:K03247]
125909430  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
125923655  RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
125927023  LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
125913187  tumor protein p73 [KO:K10148]
125925158  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125933220  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125916585  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125929964  FAS-associated death domain protein [KO:K02373]
125911772  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
125918699  BH3-interacting domain death agonist [KO:K04726]
125915138  apoptosis regulator BAX isoform X1 [KO:K02159]
125938359  bcl-2 homologous antagonist/killer [KO:K14021]
125914709  apoptosis regulator Bcl-2 [KO:K02161]
125936704  bcl-2-like protein 1 isoform X1 [KO:K04570]
125931741  bcl2-associated agonist of cell death [KO:K02158]
125929995  cytochrome c [KO:K08738]
125933126  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
125920151  cytochrome c-like [KO:K08738]
125920269  cytochrome c-like [KO:K08738]
125921158  cytochrome c-like [KO:K08738]
125919454  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
125913078  caspase-9 [KO:K04399] [EC:3.4.22.62]
125923904  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125918841  cyclin-dependent kinase inhibitor 1B [KO:K06624]
125930010  G1/S-specific cyclin-D1 [KO:K04503]
125917183  G1/S-specific cyclin-D2 [KO:K10151]
125918030  G1/S-specific cyclin-D2 [KO:K10151]
125938244  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125924535  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125917277  G1/S-specific cyclin-E1 [KO:K06626]
125917289  G1/S-specific cyclin-E1 [KO:K06626]
125919257  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125930419  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125919210  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125909406  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
125909427  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
125909383  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
125911284  T-cell-specific surface glycoprotein CD28 [KO:K06470]
125923086  interleukin-2 [KO:K05429]
125918586  interleukin-2 receptor subunit alpha [KO:K05068]
125919566  interleukin-2 receptor subunit beta [KO:K05069]
125931753  cytokine receptor common subunit gamma [KO:K05070]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125920912  E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125921776  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125929213  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125926571  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125926570  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A-like [KO:K11223]
125926542  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
125925565  low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
puc04110  Cell cycle
puc04115  p53 signaling pathway
puc04120  Ubiquitin mediated proteolysis
puc04210  Apoptosis
puc04620  Toll-like receptor signaling pathway
puc04622  RIG-I-like receptor signaling pathway
puc04630  JAK-STAT signaling pathway
puc04658  Th1 and Th2 cell differentiation
puc04660  T cell receptor signaling pathway
KO pathway
ko05162   
LinkDB

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