KEGG   PATHWAY: shab03013
Entry
shab03013                   Pathway                                
Name
Nucleocytoplasmic transport - Strigops habroptila (Kakapo)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
shab03013  Nucleocytoplasmic transport
shab03013

Other DBs
GO: 0050658
Organism
Strigops habroptila (Kakapo) [GN:shab]
Gene
115618626  AAAS; aladin isoform X1 [KO:K14320]
115604199  NUP42; nucleoporin NUP42 [KO:K14321]
115617066  GLE1; nucleoporin GLE1 [KO:K18723]
115617282  ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
115615278  RAE1; mRNA export factor [KO:K14298]
115602219  NUP98; nuclear pore complex protein Nup98-Nup96 [KO:K14297]
115617006  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
115601823  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
115601272  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
115605022  RANGAP1; ran GTPase-activating protein 1 [KO:K14319]
115607173  UBE2I; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
115616476  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
115611256  small ubiquitin-related modifier 3 [KO:K12160]
115607930  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
115606931  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
115616469  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
115614218  SEC13; protein SEC13 homolog [KO:K14004]
115605364  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
115613727  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
115600718  SEH1L; LOW QUALITY PROTEIN: nucleoporin SEH1 [KO:K14299]
115613929  NUP43; nucleoporin Nup43 [KO:K14305]
115605432  NUP37; nucleoporin Nup37 [KO:K14302]
115613415  AHCTF1; protein ELYS isoform X1 [KO:K25129]
115613417  protein ELYS-like [KO:K25129]
115612685  nuclear pore glycoprotein p62-like [KO:K14306]
115612686  nuclear pore glycoprotein p62-like [KO:K14306]
115604541  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
115610659  NUP54; LOW QUALITY PROTEIN: nucleoporin p54 [KO:K14308]
115604882  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
115616962  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
115619731  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
115619866  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
115608539  NUP35; nucleoporin NUP35 [KO:K14313]
115611114  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
115614378  NUP210; nuclear pore membrane glycoprotein 210 [KO:K14314]
115601976  POM121; nuclear envelope pore membrane protein POM 121 isoform X1 [KO:K14316]
115610230  TMEM33; transmembrane protein 33 [KO:K20724]
115611116  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
115605920  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
115616692  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
115611460  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
115601690  KPNA1; importin subunit alpha-5 [KO:K23940]
115616724  KPNA2; importin subunit alpha-1 isoform X1 [KO:K15043]
115606805  KPNA7; importin subunit alpha-8 [KO:K15043]
115611649  KPNA4; importin subunit alpha-3 [KO:K23583]
115602722  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
115609221  KPNA5; importin subunit alpha-6 isoform X1 [KO:K15042]
115616095  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
115617922  KPNB1; importin subunit beta-1 isoform X1 [KO:K14293]
115600763  TNPO1; transportin-1 [KO:K18752]
115619106  transportin-1-like isoform X1 [KO:K18752]
115603563  TNPO2; transportin-2 [KO:K18727]
115604754  TNPO3; transportin-3 [KO:K15436]
115602447  IPO5; importin-5 [KO:K20222]
115606372  IPO7; importin-7 [KO:K20223]
115604826  IPO8; importin-8 isoform X1 [KO:K18755]
115602192  IPO9; importin-9 isoform X1 [KO:K20224]
115619833  IPO11; importin-11 isoform X1 [KO:K25201]
115611889  IPO13; importin-13 isoform X1 [KO:K25202]
115612898  SNUPN; snurportin-1 [KO:K13151]
115609698  XPO1; exportin-1 isoform X1 [KO:K14290]
115615408  CSE1L; exportin-2 [KO:K18423]
115605206  XPOT; exportin-T isoform X1 [KO:K14288]
115603688  XPO4; exportin-4 isoform X1 [KO:K25203]
115613934  XPO5; exportin-5 isoform X1 [KO:K14289]
115606335  XPO6; exportin-6 isoform X1 [KO:K25204]
115618389  XPO7; exportin-7 isoform X1 [KO:K18460]
115615964  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
115614736  RAN; GTP-binding nuclear protein Ran [KO:K07936]
115615262  EEF1A2; LOW QUALITY PROTEIN: elongation factor 1-alpha 2 [KO:K03231]
115609553  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
115600686  PHAX; phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
115601338  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
115611595  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
115603070  nuclear cap-binding protein subunit 2 [KO:K12883]
115611735  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
115602695  RBM8A; RNA-binding protein 8A [KO:K12876]
115611250  MAGOH; protein mago nashi homolog [KO:K12877]
115617637  CASC3; protein CASC3 isoform X1 [KO:K14323]
115609927  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
115604501  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
115606608  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
115606062  PNN; pinin [KO:K13114]
115616589  ALYREF; THO complex subunit 4 [KO:K12881]
115618289  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
115605676  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
115613337  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
115602602  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
115602980  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
115613253  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
115615604  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
115605036  THOC1; LOW QUALITY PROTEIN: THO complex subunit 1 [KO:K12878]
115612636  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
115614096  THOC5; THO complex subunit 5 homolog [KO:K13174]
115603109  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
115614783  THOC7; THO complex subunit 7 homolog [KO:K13176]
115615569  THOC3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
shab03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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