KEGG   PATHWAY: som03420
Entry
som03420                    Pathway                                
Name
Nucleotide excision repair - Schizosaccharomyces osmophilus (fission yeast)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
som03420  Nucleotide excision repair
som03420

Other DBs
GO: 0006289
Organism
Schizosaccharomyces osmophilus (fission yeast) [GN:som]
Gene
SOMG_04581  srs2; ATP-dependent DNA helicase, UvrD subfamily [KO:K03657] [EC:5.6.2.4]
SOMG_01994  rbx1; SCF complex, Cul4-RING and CLRC ubiquitin ligase ligase E3 subunit Rbx1 [KO:K03868] [EC:2.3.2.32]
SOMG_03347  cul4; cullin 4 [KO:K10609]
SOMG_02654  ddb1; Cul4-RING E3 complex WD repeat protein subunit Ddb1 [KO:K10610]
SOMG_03765  rhp41; DNA repair protein Rhp41 [KO:K10838]
SOMG_04245  rhp42; DNA repair protein Rhp42 [KO:K10838]
SOMG_01117  rhp23; Rad23-like protein Rhp23 [KO:K10839]
SOMG_02263  ckn1; ERCC8 DNA repair-like protein [KO:K10570]
SOMG_04542  rhp26; SNF2 family DNA-dependent ATPase (ERCC6) Rhp26-like [KO:K10841]
SOMG_00861  rpb1; RNA polymerase II large subunit Rpb1 [KO:K03006] [EC:2.7.7.6]
SOMG_01700  rpb2; RNA polymerase II complex subunit Rpb2 [KO:K03010] [EC:2.7.7.6]
SOMG_02958  rpb3; RNA polymerase II subunit 3 [KO:K03011]
SOMG_01399  rpb4; DNA-directed RNA polymerase II complex subunit Rpb4 [KO:K03012]
SOMG_01786  rpb5; DNA-directed RNA polymerase I, II and III subunit Rpb5 [KO:K03013]
SOMG_04371  rpb6; DNA-directed RNA polymerase I, II and III subunit Rpb6 [KO:K03014]
SOMG_00218  rpb7; DNA-directed RNA polymerase complex II subunit Rpb7 [KO:K03015]
SOMG_02225  rpb8; DNA-directed RNA polymerase I, II and III subunit Rpb8 [KO:K03016]
SOMG_03854  rpb9; DNA-directed RNA polymerase II complex TFIIS subunit Rpb9 [KO:K03017]
SOMG_03504  rpb10; DNA-directed RNA polymerase I, II, and III subunit Rpb10 [KO:K03007]
SOMG_00843  rpc10; DNA-directed RNA polymerase I, II and III subunit Rpc10 [KO:K03009]
SOMG_01941  rpb11; RNA polymerase II complex subunit Rpb11 [KO:K03008]
SOMG_01001  mcs6; transcription factor TFIIH associated cyclin-dependent protein kinase Mcs6 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
SOMG_01012  pmh1; transcription factor TFIIK complex ubiquitin-protein ligase E3 subunit, Pmh1 [KO:K10842]
SOMG_01515  mcs2; transcription factor TFIIH complex cyclin Mcs2 [KO:K06634]
SOMG_00372  ptr8; transcription factor TFIIH complex DNA helicase (ERCC3) subunit Ptr8-like [KO:K10843] [EC:5.6.2.4]
SOMG_01547  rad15; transcription factor TFIIH complex DNA helicase (ERCC2) subunit Rad15-like [KO:K10844] [EC:5.6.2.3]
SOMG_02571  tfb5; transcription factor TFIIH complex subunit Tfb5 [KO:K10845]
SOMG_03320  tfb1; transcription factor TFIIH complex subunit Tfb1 [KO:K03141]
SOMG_04233  ssl1; transcription factor TFIIH complex subunit Ssl1 [KO:K03142]
SOMG_01280  tfb4; transcription factor TFIIH complex subunit Tfb4 [KO:K03143]
SOMG_00600  tfb2; transcription factor TFIIH complex subunit Tfb2 [KO:K03144]
SOMG_01180  rad13; DNA repair nuclease Rad13 [KO:K10846]
SOMG_05012  rhp14; XP-A family-like protein Rhp14 [KO:K10847]
SOMG_02168  ssb1; DNA replication factor A subunit Ssb1 [KO:K07466]
SOMG_04804  ssb2; single-stranded DNA binding protein Ssb2 [KO:K10739]
SOMG_04505  ssb3; DNA replication factor A subunit Ssb3 [KO:K10740]
SOMG_04271  rad16; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
SOMG_01156  swi10; ERCC1 DNA repair endonuclease non-catalytic subunit Swi10 [KO:K10849]
SOMG_01147  cdc6; DNA polymerase delta catalytic subunit Cdc6 [KO:K02327] [EC:2.7.7.7]
SOMG_04650  cdc1; DNA polymerase delta small subunit Cdc1 [KO:K02328]
SOMG_01395  cdc27; DNA polymerase delta subunit Cdc27 [KO:K03504]
SOMG_01502  cdm1; DNA polymerase delta subunit Cdm1 [KO:K03505]
SOMG_00994  cdc20; DNA polymerase epsilon catalytic subunit Pol2 [KO:K02324] [EC:2.7.7.7]
SOMG_00644  dpb2; DNA polymerase epsilon catalytic subunit B, Dpb2 [KO:K02325] [EC:2.7.7.7]
SOMG_01292  dpb4; DNA polymerase epsilon subunit Dpb4 [KO:K02326] [EC:2.7.7.7]
SOMG_00661  pcn1; PCNA [KO:K04802]
SOMG_00557  rfc1; DNA replication factor C complex subunit Rfc1 [KO:K10754]
SOMG_01721  rfc4; DNA replication factor C complex subunit Rfc4 [KO:K10755]
SOMG_02913  rfc2; DNA replication factor C complex subunit Rfc2 [KO:K10755]
SOMG_04655  rfc3; DNA replication factor C complex subunit Rfc3 [KO:K10756]
SOMG_00885  rfc5; DNA replication factor C complex subunit Rfc5 [KO:K10756]
SOMG_01924  cdc17; ATP-dependent DNA replication ligase Cdc17 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
som03020  RNA polymerase
som04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

DBGET integrated database retrieval system