Entry
Name
Lysosome - Tachysurus vachellii
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Tachysurus vachellii [GN:
tvc ]
Gene
132855502 tcirg1b; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b [KO:K02154 ]
132860717 atp6v0a1a; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
132863085 atp6v0a2a; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154 ]
132840087 si:ch73-173p19.2; V-type proton ATPase 116 kDa subunit a 1 [KO:K02154 ]
132840396 atp6v0a1b; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
132862699 atp6ap1a; ATPase H+ transporting accessory protein 1a [KO:K03662 ]
132848357 atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661 ]
132851989 si:ch211-15d5.11; oxidation resistance protein 1 isoform X1 [KO:K25442 ]
132838146 slc11a2; natural resistance-associated macrophage protein 2 [KO:K21398 ]
132843072 laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
132837525 laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387 ]
132855174 abca2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
132850173 cln5; ceroid-lipofuscinosis neuronal protein 5 homolog [KO:K12390 ]
132847849 mfsd8l2; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
132842316 mfsd8l1; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307 ]
132862117 mfsd8; major facilitator superfamily domain-containing protein 8 [KO:K12307 ]
132856718 gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239 ] [EC:2.7.8.17 ]
132846424 gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087 ]
132843091 igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564 ]
132844276 ap1m3; adaptor related protein complex 1 subunit mu 3 [KO:K12393 ]
132842621 gga3b; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404 ]
132839390 ADP-ribosylation factor-binding protein GGA2-like isoform X1 [KO:K12404 ]
132837609 litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
132839543 lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
132839548 lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363 ]
132839602 si:dkeyp-75b4.8; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363 ]
Compound
Reference
Authors
Eskelinen EL, Tanaka Y, Saftig P
Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal
Reference
Authors
Neufeld EF
Title
Lysosomal storage diseases.
Journal
Reference
Authors
von Figura K, Hasilik A
Title
Lysosomal enzymes and their receptors.
Journal
Reference
Authors
Janvier K, Bonifacino JS
Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal
Reference
Authors
Vergarajauregui S, Puertollano R
Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal
Reference
Authors
Jaskolka MC, Winkley SR, Kane PM
Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal
Reference
Authors
Majdoul S, Compton AA
Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal
Related pathway
tvc04130 SNARE interactions in vesicular transport
KO pathway
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