KEGG   DRUG: Aspirin
Entry
D00109                      Drug                                   

Name
Aspirin (JP17/USP);
Aspalon (JAN);
Acetylsalicylic acid;
Easprin (TN);
Durlaza (TN)
Formula
C9H8O4
Exact mass
180.0423
Mol weight
180.1574
Structure
Simcomp
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Anti-inflammatory
 DG01909  Anti-inflammatory drug, salicylic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01909  Anti-inflammatory drug, salicylic acid derivatives
Remark
Same as: C01405
Therapeutic category: 1143 3399
ATC code: A01AD05 B01AC06 N02BA01
Chemical structure group: DG00015
Product (DG00015): D00109<JP>
Product (mixture): D03960<JP> D10513<JP> D10527<JP> D11176<US> D11586<US> D11587<US> D11615<US> D11616<US> D11804<JP> D11849<US> D11859<US> D11860<US>
Efficacy
Analgesic, Anti-inflammatory, Antipyretic, Antirheumatic, Antiplatelet, COX inhibitor
  Disease
Myocardial infarction [DS:H01730]
Unstable angina pectoris [DS:H01632]
Chronic stable angina [DS:H01632]
Comment
Salicylic acid derivative
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Structure map
map07048  Antimigraines
map07049  Antithrombosis agents
map07110  Benzoic acid family
map07219  Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD05 Acetylsalicylic acid
      D00109  Aspirin (JP17/USP) <JP>
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC06 Acetylsalicylic acid
      D00109  Aspirin (JP17/USP) <JP>
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02B OTHER ANALGESICS AND ANTIPYRETICS
    N02BA Salicylic acid and derivatives
     N02BA01 Acetylsalicylic acid
      D00109  Aspirin (JP17/USP) <JP>
USP drug classification [BR:br08302]
 Blood Products and Modifiers
  Platelet Modifying Agents
   Platelet Modifying Agents, Other
    Aspirin
     D00109  Aspirin (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1143  Salicylates
     D00109  Aspirin (JP17/USP); Aspalon (JAN)
 3  Agents affecting metabolism
  33  Blood and body fluid agents
   339  Miscellaneous
    3399  Others
     D00109  Aspirin (JP17/USP); Aspalon (JAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00109  Aspirin (JP17/USP)
  03 Antipyretic analgesic agents
   D00109  Aspirin (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Aspirin
    D00109  Aspirin (JP17/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Aspirin
    D00109  Aspirin (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00109  Aspirin (JP17/USP) <JP>
    PTGS2 (COX2)
     D00109  Aspirin (JP17/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00109  Aspirin
  D00109  Aspirin tablets
Rx-to-OTC switch list in the USA [br08315.html]
 D00109
Other DBs
CAS: 50-78-2
PubChem: 7847177
ChEBI: 15365
ChEMBL: CHEMBL25
DrugBank: DB00945
PDB-CCD: AIN[PDBj]
LigandBox: D00109
NIKKAJI: J2.300K
LinkDB
KCF data

ATOM        13
            1   C8y C    20.2981  -15.8105
            2   C8y C    21.5226  -16.5029
            3   C8x C    19.0928  -16.5029
            4   C6a C    20.2981  -14.6227
            5   C8x C    21.5226  -17.9133
            6   O7a O    22.7278  -15.8040
            7   C8x C    19.0928  -17.9133
            8   O6a O    21.5033  -13.9240
            9   O6a O    19.0863  -13.9304
            10  C8x C    20.2981  -18.6250
            11  C7a C    23.9396  -16.4964
            12  C1a C    25.1450  -15.7977
            13  O6a O    23.9396  -17.8942
BOND        13
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11   11  12 1
            12   11  13 2
            13    7  10 2

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