KEGG   DRUG: シルデナフィルクエン酸塩Help
エントリ  
D02229                      Drug                                   

一般名   
シルデナフィルクエン酸塩 (JAN);
Sildenafil citrate (JAN/USAN)
商品名   
米国の商品 
  後発品
SILDENAFIL (A-S Medication Solutions), SILDENAFIL CITRATE (A-S Medication Solutions), SILDENAFIL (Aidarex Pharmaceuticals LLC), SILDENAFIL (Aidarex Pharmaceuticals LLC), SILDENAFIL (Ajanta Pharma Limited), SILDENAFIL (American Health Packaging), SILDENAFIL (Amneal Pharmaceuticals LLC), SILDENAFIL (Amneal Pharmaceuticals LLC), SILDENAFIL (Apotex Corp.), SILDENAFIL (Aurobindo Pharma Limited), SILDENAFIL (Aurobindo Pharma Limited), SILDENAFIL (AvKARE), SILDENAFIL (AvKARE), SILDENAFIL (AvPAK), SILDENAFIL (BluePoint Laboratories), SILDENAFIL (BluePoint Laboratories), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Bryant Ranch Prepack), SILDENAFIL (Camber Pharmaceuticals), SILDENAFIL (Camber Pharmaceuticals), SILDENAFIL (DirectRX), SILDENAFIL (DirectRX), SILDENAFIL (H. J. Harkins Company), SILDENAFIL (Lake Erie Medical DBA Quality C), SILDENAFIL (Lake Erie Medical DBA Quality Care Products LLC), SILDENAFIL (Macleods Pharmaceuticals Limited), SILDENAFIL (Northwind Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (NuCare Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (Preferred Pharmaceuticals), SILDENAFIL (Preferred Pharmaceuticals), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (Proficient Rx LP), SILDENAFIL (REMEDYREPACK), SILDENAFIL (REMEDYREPACK), SILDENAFIL (Teva Pharmaceuticals USA), SILDENAFIL (Teva Pharmaceuticals USA), SILDENAFIL CITRATE (Torrent Pharmaceuticals Limited), SILDENAFIL (TruPharma LLC), SILDENAFIL (Unit Dose Services), SILDENAFIL CITRATE (Vensun Pharmaceuticals), SILDENAFIL (Aphena Pharma Solutions - Tennessee), SILDENAFIL (AuroMedics Pharma LLC), SILDENAFIL (Greenstone LLC), SILDENAFIL (KAISER FOUNDATION HOSPITALS), SILDENAFIL CITRATE (Major Pharmaceuticals), SILDENAFIL (PD-Rx Pharmaceuticals), SILDENAFIL (Preferred Pharmaceuticals), SILDENAFIL CITRATE (Torrent Pharmaceuticals Limited), SILDENAFIL (Mylan Pharmaceuticals)
組成式   
C22H30N6O4S. C6H8O7
質量    
666.2319
分子量   
666.6999
構造式   
Mol fileKCF fileDB search
クラス   
循環器系用薬
 DG01509  ホスホジエステラーゼV阻害薬
酵素基質
 DG01642  CYP2C9により代謝される薬剤
 DG01633  CYP3Aにより代謝される薬剤
コード   
薬効分類: 2190 2590
ATCコード: G04BE03
化学構造グループ: DG00484
商品 (DG00484): D02229<JP/US>
効能    
血管拡張薬, 勃起不全治療薬, ホスホジエステラーゼV阻害薬
  疾患
肺動脈性肺高血圧症 [DS:H01621]
ターゲット 
PDE5 [HSA:8654] [KO:K13762]
  パスウェイ
hsa04022  cGMP-PKG シグナル伝達経路
代謝    
Enzyme: CYP3A4 [HSA:1576]; CYP2C9 [HSA:1559]
相互作用  
Drug interaction
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   219  その他の循環器官用薬
    2190  その他の循環器官用薬
     D02229  シルデナフィルクエン酸塩 (JAN)
  25  泌尿生殖器官及び肛門用薬
   259  その他の泌尿生殖器官及び肛門用薬
    2590  その他の泌尿生殖器官及び肛門用薬
     D02229  シルデナフィルクエン酸塩 (JAN)
医療用医薬品のATC分類 [BR:jp08303]
 G 泌尿生殖器系と性ホルモン
  G04 泌尿器科用薬
   G04B 泌尿器科用薬
    G04BE 勃起不全用薬
     G04BE03 シルデナフィル
      D02229  シルデナフィルクエン酸塩 (JAN) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 呼吸器薬
  肺血圧降下薬
   シルデナフィル
    D02229  シルデナフィルクエン酸塩 (JAN)
Target-based classification of drugs  [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphodiesterase
    PDE5
     D02229  Sildenafil citrate (JAN/USAN) <JP/US>
治療薬の医薬品クラス [jp08360.html]
 内分泌・ホルモン関連薬
  D02229
BRITE hierarchy
リンク   
CAS: 171599-83-0
PubChem: 7849288
ChEBI: 58987
ChEMBL: CHEMBL1737
DrugBank: DB00203
LigandBox: D02229
日化辞: J974.104F
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