KEGG   ORTHOLOGY: K00089
Entry
K00089                      KO                                     

Name
AKR1C2
Definition
3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
Pathway
ko00140  Steroid hormone biosynthesis
ko05204  Chemical carcinogenesis
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Other DBs
RN: R08955 R08957 R08960
GO: 0047026
Genes
HSA: 1646(AKR1C2)
PTR: 100612191(AKR1C2)
PPS: 103783188
NLE: 100603603
Reference
PMID:7998972
  Authors
Del Bello B, Maellaro E, Sugherini L, Santucci A, Comporti M, Casini AF
  Title
Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem J 304 ( Pt 2):385-90 (1994)
DOI:10.1042/bj3040385
Reference
PMID:8274401
  Authors
Qin KN, New MI, Cheng KC
  Title
Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
  Journal
J Steroid Biochem Mol Biol 46:673-9 (1993)
DOI:10.1016/0960-0760(93)90308-j
  Sequence
[hsa:1646]
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