KEGG   ORTHOLOGY: K03794
Entry
K03794                      KO                                     
Symbol
sirB
Name
sirohydrochlorin ferrochelatase [EC:4.99.1.4]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
Module
M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
Reaction
R02864  S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K03794  sirB; sirohydrochlorin ferrochelatase
Enzymes [BR:ko01000]
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4  sirohydrochlorin ferrochelatase
     K03794  sirB; sirohydrochlorin ferrochelatase
Other DBs
COG: COG2138
GO: 0004325
Genes
ATH: AT1G50170(SIRB)
ALY: 9330296
CRB: 17899612
CSAT: 104742549 104758326 104777944
EUS: EUTSA_v10011756mg
BRP: 103832890
BNA: 106418713 106439044
BOE: 106328307
RSZ: 108834054 130498400
THJ: 104801894 104807109
CIT: 102627039
MINC: 123222760
TCC: 18600811
GRA: 105768925
GAB: 108481280
EGR: 104422628
GMX: 100500125
GSJ: 114411661
VAR: 108344900
VUN: 114182686
VUM: 124823623
CCAJ: 109808172
APRC: 113867821
TPRA: 123906622
CAM: 101489141
LJA: Lj2g3v0946310.1(Lj2g3v0946310.1)
ADU: 107490059
LANG: 109354671
FVE: 101314340
PPER: 18782578
PMUM: 103329819
PAVI: 110755603
ZJU: 107415490
MNT: 21400497
CSAV: 115700550
CSV: 101223042
CMO: 103498093
BHJ: 120080322
MCHA: 111006726
CMAX: 111489668
CMOS: 111445470
RCU: 8289812
JCU: 105641377
HBR: 110641907
MESC: 110605517
POP: 7486640
PEU: 105109646
PALZ: 118050682
JRE: 109007249
CILL: 122299236
CAVE: 132181285
QSU: 112014635
QLO: 115976611
TWL: 120010550
VVI: 100244073
VRI: 117929576
SLY: 101257032
SPEN: 107008700
SOT: 102599852
SSTN: 125849011
SDUL: 129874406
CANN: 107860669
NSY: 104234139
NTO: 104120867
NAU: 109230744
ITR: 115998256
SIND: 105177107
OEU: 111367070
EGT: 105969521
SMIL: 130989352
SHIS: 125207391
APAN: 127258119
HAN: 110923557
ECAD: 122610077
LSV: 111914357
CCAV: 112513063
DCR: 108211310
RVL: 131300310
AEW: 130763702
ATRI: 130817751
MOF: 131168453
NNU: 104593131
MING: 122079977
TSS: 122671546
OSA: 4329080
DOSA: Os02t0296800-01(Os02g0296800)
OBR: 102709053
OGL: 127761092
SBI: 8081646
SITA: 101756522
SVS: 117838524
PHAI: 112879049
PDA: 103702509
EGU: 105040911
DCT: 110103837
PEQ: 110021992
MSIN: 131235507
NCOL: 116264450
ATR: 18424427
PPP: 112280373
MPP: MICPUCDRAFT_11758(JGI:MicpuC2_11758)
AAF: AURANDRAFT_32321(CSC1)
METL: U737_17015
CYQ: Q91_0662
GAI: IMCC3135_06970(sirB)
TBN: TBH_C2443
ENM: EBS_0826(cbiX)
HEBR: AEBR_1397
GSK: KN400_2943(cbiX)
GME: Gmet_0476(cbiX)
GEM: GM21_3612
GEB: GM18_0543
GUR: Gura_0032
GEO: Geob_0029(cbiX)
GBM: Gbem_3546(cbiX)
GBN: GEOBRER4_34660(cbiX)
DEU: DBW_3100
DTO: TOL2_C07420(cbiX)
BSU: BSU15620(sirB)
BSR: I33_1749
BSL: A7A1_3523
BSH: BSU6051_15620(sirB)
BSUT: BSUB_01693(sirB)
BSUL: BSUA_01693(sirB)
BSUS: Q433_08965
BSO: BSNT_08073(ylnE)
BSQ: B657_15620(sirB)
BSX: C663_1606(sirB)
BSS: BSUW23_08040(sirB)
BST: GYO_1911
BLI: BL02287(sirB)
BLD: BLi01783(sirB)
BLH: BaLi_c18160(sirB)
BAQ: BACAU_1516(sirB)
BYA: BANAU_1513(sirB)
BAMP: B938_08025
BQY: MUS_1712(sirB)
BAML: BAM5036_1481(sirB)
BAMA: RBAU_1521(sirB)
BAMN: BASU_1501(sirB)
BAMB: BAPNAU_2208(sirB)
BAMT: AJ82_08845
BAMY: V529_15010(sirB)
BMP: NG74_01608(sirB)
BAO: BAMF_1633(sirB)
BAZ: BAMTA208_09340(sirB)
BQL: LL3_01721(sirB)
BXH: BAXH7_01900(sirB)
BAMI: KSO_011630
BAMC: U471_15840
BAMF: U722_08205
BSON: S101395_03170(sirB)
BMOJ: HC660_16270(sirB)
BSTR: QI003_08410(sirB) QI003_11835(sirB)
BAN: BA_1446
BAR: GBAA_1446
BAT: BAS1336
BAI: BAA_1516
BANT: A16_14930
BANR: A16R_15090
BANS: BAPAT_1364
BANV: DJ46_272
BCE: BC1427
BCA: BCE_1550
BCQ: BCQ_1500
BNC: BCN_1405
BCER: BCK_01240
BTT: HD73_1657
BTHI: BTK_08430
BTM: MC28_0664
BTG: BTB_c14690(sirB1)
BTI: BTG_13605
BTW: BF38_2647
BWW: bwei_2889(cbiX) bwei_3570(sirB)
BMYO: BG05_4464
BMYC: DJ92_4077
BPU: BPUM_1461
BPUM: BW16_08170
BPUS: UP12_07605
BMET: BMMGA3_02585(sirB1) BMMGA3_07165(sirB2)
BGY: BGLY_1777(sirB)
BAER: BAE_15200
BCAB: EFK13_08635(sirB)
BRY: M0696_08490(sirB)
BJS: MY9_1708
BACW: QR42_07465
BACP: SB24_01980
BACB: OY17_10800
BACO: OXB_3546
BACY: QF06_06835
BACL: BS34A_17310(sirB)
BALM: BsLM_1660
BMQ: BMQ_4927(sirB)
BMD: BMD_4913(sirB)
BMEG: BG04_1915
BEO: BEH_22020
OIH: OB1656
GKA: GK0412
GTN: GTNG_0384
GEA: GARCT_00449(sirB)
PCAL: BV455_01332(sirB)
PARG: PspKH34_34100(sirB)
AFL: Aflv_0311
AAMY: GFC30_827
AAYD: B379_04900
LSP: Bsph_0590
HHD: HBHAL_2679(sirB)
HLI: HLI_01915
VPN: A21D_01518(sirB)
BLEN: NCTC4824_00848(cbiX) NCTC4824_02182(sirB)
BAG: Bcoa_0996
BCOA: BF29_2737
SHA: SH0650
SHH: ShL2_00550(cbiX)
SSP: SSP2405
SAGQ: EP23_07700
SARL: SAP2_03010
STAP: AOB58_1722
SSTE: SAMEA4384403_0219(cbiX)
PALO: E6C60_0738
PNK: AASFL403_15515(cbiX)
PKP: SK3146_04614(sirB)
BTS: Btus_1798
EFF: skT53_07470(cbiX)
SIV: SSIL_1292
JEO: JMA_24780
KZO: NCTC404_02360(cbiX)
SALQ: SYNTR_1652
DED: DHBDCA_p2928(cbiX)
DEC: DCF50_p2932(cbiX)
DAU: Daud_1857
CTHM: CFE_1399
LCRE: Pla8534_12260(cbiX)
BVO: Pan97_02560(cbiX)
AMUC: Pan181_32630(sirB)
PND: Pla175_33250(sirB)
PLM: Plim_2903
PEH: Spb1_36590(cbiX)
PLS: VT03_25555(cbiX)
PLH: VT85_14845(cbiX)
FMR: Fuma_05043(cbiX)
GMR: GmarT_04790(cbiX)
GPN: Pan110_05400(cbiX)
MRI: Mal4_32890(cbiX)
SDYN: Mal52_37680(cbiX)
PLON: Pla110_40070(cbiX)
GES: VT84_01780(cbiX)
FTJ: FTUN_3234
ULI: ETAA1_07360(cbiX)
IPA: Isop_0994
SACI: Sinac_3293
PBOR: BSF38_03912(cbiX)
AGV: OJF2_39510(cbiX)
PHM: PSMK_16590(cbiX)
PCOR: KS4_35200(cbiX_2)
SUS: Acid_7485
TYE: THEYE_A1172(cbiX)
TAA: NMY3_01893(cbiX)
NFN: NFRAN_2704(cbiX)
 » show all
Reference
  Authors
Raux E, Leech HK, Beck R, Schubert HL, Santander PJ, Roessner CA, Scott AI, Martens JH, Jahn D, Thermes C, Rambach A, Warren MJ
  Title
Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium.
  Journal
Biochem J 370:505-16 (2003)
DOI:10.1042/BJ20021443
  Sequence
[bmq:BMQ_4927]
Reference
  Authors
Saha K, Webb ME, Rigby SE, Leech HK, Warren MJ, Smith AG
  Title
Characterization of the evolutionarily conserved iron-sulfur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana.
  Journal
Biochem J 444:227-37 (2012)
DOI:10.1042/BJ20111993
  Sequence
[ath:AT1G50170]
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