| Entry |
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| Name |
trypanothione-disulfide reductase;
trypanothione reductase;
NADPH2:trypanothione oxidoreductase
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| Class |
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
trypanothione:NADP+ oxidoreductase
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| Reaction(IUBMB) |
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ [RN: R03821]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)
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| History |
EC 1.8.1.12 created 1989 as EC 1.6.4.8, transferred 2002 to EC 1.8.1.12
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| Pathway |
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| Orthology |
| K04283 | trypanothione-disulfide reductase |
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| Genes |
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| Reference |
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| Authors |
Shames SL, Fairlamb AH, Cerami A, Walsh CT. |
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| Title |
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Marsh IR, Bradley M. |
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| Title |
Substrate specificity of trypanothione reductase. |
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| Journal |
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| Reference |
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| Authors |
Cunningham ML, Fairlamb AH. |
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| Title |
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.8.1.12 |
| ExPASy - ENZYME nomenclature database: | 1.8.1.12 |
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| LinkDB |
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