KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09106 Metabolism of other amino acids
00480 Glutathione metabolism
K04283 TRYR; trypanothione-disulfide reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.8 Acting on a sulfur group of donors
1.8.1 With NAD+ or NADP+ as acceptor
1.8.1.12 trypanothione-disulfide reductase
K04283 TRYR; trypanothione-disulfide reductase
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases.
Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)
History
EC 1.8.1.12 created 1989 as EC 1.6.4.8, transferred 2002 to EC 1.8.1.12
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases.
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.8 Acting on a sulfur group of donors
1.8.1 With NAD+ or NADP+ as acceptor
1.8.1.12
R08356 Bis(glutathionyl)spermine + NADP+ <=> Bis(glutathionyl)spermine disulfide + NADPH + H+