KEGG   ORTHOLOGY: K09186
Entry
K09186                      KO                                     

Name
MLL1
Definition
[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]
Pathway
ko00310  Lysine degradation
ko01100  Metabolic pathways
ko04934  Cushing syndrome
ko05202  Transcriptional misregulation in cancer
Disease
H00001  B-cell acute lymphoblastic leukemia
H00002  T-cell acute lymphoblastic leukemia
H01879  Wiedemann-Steiner syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   03036 Chromosome and associated proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Other DBs
RN: R03875 R04866 R04867
GO: 0042800
Genes
HSA: 4297(KMT2A)
PTR: 451587(KMT2A)
PPS: 100984332(KMT2A)
GGO: 101129366(KMT2A)
PON: 100441102(KMT2A)
NLE: 100604245(KMT2A)
MCC: 705511(KMT2A)
CSAB: 103248594(KMT2A)
RRO: 104665589(KMT2A)
RBB: 108536375(KMT2A)
CJC: 100391138(KMT2A)
SBQ: 101029847(KMT2A)
MMU: 214162(Kmt2a)
MCAL: 110301786(Kmt2a)
MPAH: 110327485(Kmt2a)
RNO: 315606(Kmt2a)
MUN: 110549115(Kmt2a)
CGE: 100760424(Kmt2a)
NGI: 103748298(Kmt2a)
HGL: 101716671(Kmt2a)
CCAN: 109689973(Kmt2a)
OCU: 100353733(KMT2A)
TUP: 102473382(KMT2A)
CFA: 479417(KMT2A)
VVP: 112920160(KMT2A)
AML: 100484220(KMT2A)
UMR: 103662507(KMT2A)
UAH: 113259992(KMT2A)
ORO: 101363669(KMT2A)
ELK: 111153928
FCA: 101090288(KMT2A)
PTG: 102956940(KMT2A)
PPAD: 109278556(KMT2A)
AJU: 106966460(KMT2A)
BTA: 508330(KMT2A)
BOM: 102280025(KMT2A)
BIU: 109569413(KMT2A)
BBUB: 102401126(KMT2A)
CHX: 102169033(KMT2A)
OAS: 101101916(KMT2A)
SSC: 100623006(KMT2A)
CFR: 102517824(KMT2A)
CDK: 105090168(KMT2A)
BACU: 103014183(KMT2A)
LVE: 103068531(KMT2A)
OOR: 101278571(KMT2A)
DLE: 111166868(KMT2A)
ECB: 100071238(KMT2A)
EPZ: 103546689(KMT2A)
EAI: 106840333(KMT2A)
HAI: 109385301(KMT2A)
DRO: 112314381(KMT2A)
RAY: 107502258(KMT2A)
MJV: 108384991(KMT2A)
LAV: 100653681(KMT2A)
TMU: 101351964
MDO: 100031440(KMT2A)
SHR: 100924557(KMT2A)
PCW: 110207193(KMT2A)
OAA: 100086068(KMT2A)
GGA: 414897(KMT2A)
MGP: 100540662(KMT2A)
CJO: 107324133(KMT2A)
NMEL: 110387546(KMT2A)
APLA: 101797321(KMT2A)
ACYG: 106039772(KMT2A)
TGU: 100231049(KMT2A)
LSR: 110470458(KMT2A)
SCAN: 103822784(KMT2A)
GFR: 102036439(KMT2A)
FAB: 101813917(KMT2A)
PHI: 102103515(KMT2A)
PMAJ: 107214385(KMT2A)
CCAE: 111939213(KMT2A)
CCW: 104692048(KMT2A)
ETL: 114056306(KMT2A)
FPG: 101922729(KMT2A)
FCH: 102059401(KMT2A)
CLV: 102084453(KMT2A)
EGZ: 104135361(KMT2A)
NNI: 104016208(KMT2A)
ACUN: 113488577(KMT2A)
PADL: 103916551(KMT2A)
AAM: 106485191(KMT2A)
ASN: 102385246(KMT2A)
AMJ: 102572253(KMT2A)
PSS: 102463628(KMT2A)
CMY: 102941272(KMT2A)
CPIC: 101941687(KMT2A)
ACS: 100560745(kmt2a)
XTR: 100135006(kmt2a)
DRE: 557048(kmt2a)
CCAR: 109103211
IPU: 108277661(kmt2a)
PHYP: 113533005(kmt2a)
AMEX: 103035686
EEE: 113579441(kmt2a)
TRU: 101079297(kmt2a)
LCO: 104936774(kmt2a)
MZE: 101478918(kmt2a)
ONL: 100700211(kmt2a)
OLA: 101171020(kmt2a)
XMA: 102233842(kmt2a)
XCO: 114133379(kmt2a)
PRET: 103474566(kmt2a)
CVG: 107088316(kmt2a)
NFU: 107380358(kmt2a)
KMR: 108246035(kmt2a)
ALIM: 106533989(kmt2a)
AOCE: 111584353
CSEM: 103378141(kmt2a)
POV: 109630237(kmt2a)
LCF: 108886384(kmt2a)
SDU: 111228034(kmt2a)
SLAL: 111650938(kmt2a)
HCQ: 109529394(kmt2a)
BPEC: 110154093(kmt2a)
MALB: 109960262(kmt2a)
SASA: 106612477(kmt2a)
ELS: 105011706(kmt2a)
SFM: 108936191(kmt2a)
PKI: 111846253(kmt2a)
CIN: 100180972
SPU: 579728
DME: Dmel_CG8651(trx)
DSI: Dsimw501_GD20433(Dsim_GD20433)
DPE: 6587342
DMN: 108155493
DAZ: 108621479
DNV: 115563744
DHE: 111593273
AAG: 5573555
AALB: 109416761
AME: 408716
BIM: 100748492
BTER: 100646252
CCAL: 108625224
TCA: 658843(trithorax)
 » show all
Reference
  Authors
Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF
  Title
Structural and biochemical insights into MLL1 core complex assembly.
  Journal
Structure 19:101-8 (2011)
DOI:10.1016/j.str.2010.09.022
  Sequence
[hsa:4297]
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x
Reference
PMID:8703835
  Authors
Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R
  Title
Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.
  Journal
Br J Haematol 93:966-72 (1996)
DOI:10.1046/j.1365-2141.1996.d01-1748.x
  Sequence
[hsa:4297]
LinkDB

DBGET integrated database retrieval system