KEGG   ORTHOLOGY: K09186Help
Entry
K09186                      KO                                     

Name
MLL1
Definition
[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]
Pathway
ko00310  Lysine degradation
ko04934  Cushing syndrome
ko05202  Transcriptional misregulation in cancer
Disease
H00001  B-cell acute lymphoblastic leukemia
H00002  T-cell acute lymphoblastic leukemia
H01879  Wiedemann-Steiner syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   03036 Chromosome and associated proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 Trithorax
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
BRITE hierarchy
Other DBs
RN: R03875 R04866 R04867
GO: 0042800
Genes
HSA: 4297(KMT2A)
PTR: 451587(KMT2A)
PPS: 100984332(KMT2A)
GGO: 101129366(KMT2A)
PON: 100441102(KMT2A)
NLE: 100604245(KMT2A)
MCC: 705511(KMT2A)
MCF: 101866311(KMT2A)
CSAB: 103248594(KMT2A)
RRO: 104665589(KMT2A)
RBB: 108536375(KMT2A)
CJC: 100391138(KMT2A)
SBQ: 101029847(KMT2A)
MMU: 214162(Kmt2a)
MCAL: 110301786(Kmt2a)
MPAH: 110327485(Kmt2a)
RNO: 315606(Kmt2a)
MUN: 110549115(Kmt2a)
CGE: 100760424(Kmt2a)
NGI: 103748298(Kmt2a)
HGL: 101716671(Kmt2a)
CCAN: 109689973(Kmt2a)
OCU: 100339782 100353733(KMT2A)
TUP: 102473382(KMT2A)
CFA: 479417(KMT2A)
VVP: 112920160(KMT2A)
AML: 100484220(KMT2A)
UMR: 103662507(KMT2A)
UAH: 113259992(KMT2A)
ORO: 101363392 101363669(KMT2A)
FCA: 101090288(KMT2A)
PTG: 102956940(KMT2A)
PPAD: 109278556(KMT2A)
AJU: 106966460(KMT2A)
BTA: 508330(KMT2A)
BOM: 102280025(KMT2A)
BIU: 109569413(KMT2A)
BBUB: 102401126(KMT2A)
CHX: 102169033(KMT2A)
OAS: 101101916(KMT2A)
SSC: 100623006(KMT2A)
CFR: 102517824(KMT2A)
CDK: 105090168(KMT2A)
BACU: 103014183(KMT2A)
LVE: 103068531(KMT2A)
OOR: 101278571(KMT2A)
DLE: 111166868(KMT2A)
PCAD: 102981445(KMT2A)
ECB: 100071238(KMT2A)
EPZ: 103546689(KMT2A)
EAI: 106840333(KMT2A)
MYB: 102246785(KMT2A)
MYD: 102766910(KMT2A) 107182758
HAI: 109385301(KMT2A)
DRO: 112314381(KMT2A)
PALE: 102893336(KMT2A)
RAY: 107502258(KMT2A)
MJV: 108384991(KMT2A)
LAV: 100653681(KMT2A)
TMU: 101351964
MDO: 100031440(KMT2A)
SHR: 100924557(KMT2A)
PCW: 110207193(KMT2A)
OAA: 100086068(KMT2A)
GGA: 414897(KMT2A)
MGP: 100540662(KMT2A)
CJO: 107324133(KMT2A)
NMEL: 110387546(KMT2A)
APLA: 101797321(KMT2A)
ACYG: 106039772(KMT2A)
TGU: 100231049(KMT2A)
LSR: 110470458(KMT2A)
SCAN: 103822784(KMT2A)
GFR: 102036439(KMT2A)
FAB: 101813917(KMT2A)
PHI: 102103515(KMT2A)
PMAJ: 107214385(KMT2A)
CCAE: 111939213(KMT2A)
CCW: 104692048(KMT2A)
ETL: 114056306(KMT2A)
FPG: 101922729(KMT2A)
FCH: 102059401(KMT2A)
CLV: 102084453(KMT2A)
EGZ: 104135361(KMT2A)
NNI: 104016208(KMT2A)
ACUN: 113488577(KMT2A)
PADL: 103916551(KMT2A)
AAM: 106485191(KMT2A)
ASN: 102385246(KMT2A)
AMJ: 102572253(KMT2A)
PSS: 102463628(KMT2A)
CMY: 102941272(KMT2A)
CPIC: 101941687(KMT2A)
ACS: 100560745(kmt2a)
PVT: 110079453(KMT2A)
PBI: 103067762(KMT2A)
PMUR: 107284778(KMT2A)
PMUA: 114585722(KMT2A)
GJA: 107112539(KMT2A)
XTR: 100135006(kmt2a)
NPR: 108794984(KMT2A)
DRE: 557048(kmt2a)
IPU: 108277661(kmt2a)
PHYP: 113533005(kmt2a)
AMEX: 103035686
EEE: 113579441(kmt2a)
TRU: 101079297(kmt2a)
LCO: 104936774(kmt2a)
MZE: 101478918(kmt2a)
ONL: 100700211(kmt2a)
OLA: 101171020(kmt2a)
XMA: 102233842(kmt2a)
XCO: 114133379(kmt2a)
PRET: 103474566(kmt2a)
CVG: 107088316(kmt2a)
NFU: 107380358(kmt2a)
KMR: 108246035(kmt2a)
ALIM: 106533989(kmt2a)
AOCE: 111584353
CSEM: 103378141(kmt2a)
POV: 109630237(kmt2a)
LCF: 108886384(kmt2a)
SDU: 111228034(kmt2a)
SLAL: 111650938(kmt2a) 111671476
HCQ: 109529394(kmt2a)
BPEC: 110154093(kmt2a)
MALB: 109960262(kmt2a)
SASA: 106612477(kmt2a)
ELS: 105011706(kmt2a)
PKI: 111846253(kmt2a)
LCM: 102357046(KMT2A)
CMK: 103180354(kmt2a)
CIN: 100180972
SPU: 579728
APLC: 110983880
DME: Dmel_CG8651(trx)
DER: 6552649
DSI: Dsimw501_GD20433(Dsim_GD20433)
DSR: 110186923
DPE: 6587342
DWI: 6647544
DAZ: 108621479
DHE: 111593273
DVI: Dvir_GJ22599(Dvir_trx)
MDE: 101896996
LCQ: 111676545
AAG: 5573555
AALB: 109416761
AME: 408716
BIM: 100748492
BTER: 100646252
CCAL: 108625224
OBB: 114870889
SOC: 105197865
AEC: 105145559
ACEP: 105626604
PBAR: 105422098
VEM: 105567631
HST: 105191719
DQU: 106752351
CFO: 105251303
LHU: 105668075
PGC: 109854362
OBO: 105276941
PCF: 106791610
MDL: 103574171
TCA: 658843(trithorax)
DPA: 109540960
ATD: 109609440
NVL: 108569866
BMOR: 101742231
PMAC: 106715470
PRAP: 110992468
HAW: 110377249
TNL: 113499687
PXY: 105383381
DNX: 107167618
AGS: 114126838
RMD: 113550984
BTAB: 109039140
CLEC: 106669164
ZNE: 110832202
PVM: 113804137
PTEP: 107448725
CRG: 105347805
MYI: 110462400
OBI: 106883428
SHX: MS3_01195
ADF: 107345259
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF
  Title
Structural and biochemical insights into MLL1 core complex assembly.
  Journal
Structure 19:101-8 (2011)
DOI:10.1016/j.str.2010.09.022
  Sequence
[hsa:4297]
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x
Reference
PMID:8703835
  Authors
Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R
  Title
Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.
  Journal
Br J Haematol 93:966-72 (1996)
DOI:10.1046/j.1365-2141.1996.d01-1748.x
  Sequence
[hsa:4297]
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