KEGG   ORTHOLOGY: K10251Help
Entry
K10251                      KO                                     

Name
HSD17B12, KAR, IFA38
Definition
17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
Pathway
ko00062  Fatty acid elongation
ko00140  Steroid hormone biosynthesis
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01212  Fatty acid metabolism
Module
M00415  Fatty acid elongation in endoplasmic reticulum
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   00140 Steroid hormone biosynthesis
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   01040 Biosynthesis of unsaturated fatty acids
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
    1.1.1.330  very-long-chain 3-oxoacyl-CoA reductase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
BRITE hierarchy
Other DBs
RN: R02352 R02353 R04681 R04682 R07759 R08945 R08980 R10826
COG: COG0300
GO: 0004303
Genes
HSA: 51144(HSD17B12)
PTR: 741010(HSD17B12)
PPS: 100971612(HSD17B12)
GGO: 101126579(HSD17B12)
PON: 100439025(HSD17B12)
NLE: 100600308(HSD17B12)
MCC: 106993263(HSD17B12)
MCF: 101867269(HSD17B12)
CSAB: 103237147(HSD17B12)
RRO: 104673891(HSD17B12)
RBB: 108519261(HSD17B12)
CJC: 100399351(HSD17B12)
SBQ: 101037623(HSD17B12)
MMU: 56348(Hsd17b12)
MCAL: 110306681(Hsd17b12)
MPAH: 110318386(Hsd17b12)
RNO: 84013(Hsd17b12)
MUN: 110540580(Hsd17b12)
CGE: 100751291(Hsd17b12)
NGI: 103746669(Hsd17b12)
HGL: 101706276 101717552(Hsd17b12)
CCAN: 109700741(Hsd17b12)
OCU: 100346603(HSD17B12) 103347152
TUP: 102495234(HSD17B12)
CFA: 475939(HSD17B12)
VVP: 112914444(HSD17B12)
AML: 100484147(HSD17B12)
UMR: 103672348(HSD17B12)
UAH: 113265017(HSD17B12)
ORO: 101367938(HSD17B12)
FCA: 101082595(HSD17B12)
PTG: 102963001(HSD17B12)
AJU: 106978054(HSD17B12)
BTA: 508455 789567(HSD17B12)
BOM: 102274407(HSD17B12) 102278627
BIU: 109569664(HSD17B12) 109572870
BBUB: 102394606 102395741(HSD17B12)
CHX: 102169696 102186887(HSD17B12)
OAS: 101110086(HSD17B12) 101112590 114109406
SSC: 100312972(HSD17B12)
CFR: 102505228 102515430(HSD17B12)
CDK: 105095461 105106832(HSD17B12)
BACU: 102998439(HSD17B12)
LVE: 103068441(HSD17B12)
OOR: 101273198 101279942(HSD17B12)
DLE: 111180753 111184015(HSD17B12)
ECB: 100050075(HSD17B12) 100070719
EPZ: 103556323 103556451(HSD17B12) 103566841
EAI: 106843965(HSD17B12) 106848436
MYB: 102263289 102263627(HSD17B12)
MYD: 102758451 102766960(HSD17B12)
MNA: 107525487(HSD17B12) 107536738
HAI: 109391968(HSD17B12)
RSS: 109441958 109455108(HSD17B12) 109459904
DRO: 112303253(HSD17B12) 112312939
PALE: 102889386(HSD17B12)
LAV: 100656306(HSD17B12) 111749606
MDO: 100013277(HSD17B12)
SHR: 100917982(HSD17B12) 100923950
OAA: 100079057(HSD17B12)
GGA: 769787(HSD17B12)
MGP: 104911119(HSD17B12)
CJO: 107314810(HSD17B12)
APLA: 101803586(HSD17B12)
ACYG: 106044159(HSD17B12)
TGU: 100223843(HSD17B12)
LSR: 110472034(HSD17B12)
SCAN: 103827003(HSD17B12)
GFR: 102039695(HSD17B12)
FAB: 101807632(HSD17B12)
PHI: 102106801(HSD17B12)
PMAJ: 107206004(HSD17B12)
CCAE: 111930136(HSD17B12)
CCW: 104688088(HSD17B12)
ETL: 114062366(HSD17B12)
FPG: 101917180(HSD17B12)
FCH: 102056639(HSD17B12)
CLV: 102085015(HSD17B12)
EGZ: 104134096(HSD17B12)
NNI: 104019569(HSD17B12)
ACUN: 113481381(HSD17B12)
AAM: 106498375(HSD17B12)
ASN: 102368497 102381002(HSD17B12)
AMJ: 102559362(HSD17B12)
PSS: 102445815(HSD17B12) 102455451 112544543
CMY: 102938030(HSD17B12) 102939820
CPIC: 101950937(HSD17B12)
PVT: 110081502(HSD17B12)
PBI: 103049647(HSD17B12)
PMUR: 107289668(HSD17B12)
GJA: 107119118(HSD17B12) 107120158
XLA: 108711776 379747(hsd17b12.S) 444506(LOC100497556.S) 495218(hsd17b12.L)
XTR: 100497556 549988(hsd17b12)
NPR: 108785839(HSD17B12) 108794729 108800692
DRE: 322626(hsd17b12b) 327417(hsd17b12a)
IPU: 100528251(dh12b) 108259770 108275383(hsd17b12)
PHYP: 113529736(hsd17b12) 113531207 113540909
AMEX: 103024613 103027081(hsd17b12) 103033448
TRU: 101067779(hsd17b12) 101069843 101072347
LCO: 104922399(hsd17b12) 104925842 104937328
MZE: 101464359 101469758 101474165(hsd17b12)
XMA: 102221080 102222061 102227570(hsd17b12)
XCO: 114143196 114153382 114157070(hsd17b12)
KMR: 108234813 108245742(hsd17b12) 108248270
CSEM: 103378812 103379805(hsd17b12) 103395421
SDU: 111223976 111229620(hsd17b12) 111234380
MALB: 109959449 109965090 109973524(hsd17b12)
ELS: 105006117(hsd17b12) 105023923 105025310
SFM: 108918746 108934676 108942280(hsd17b12)
PKI: 111841056 111859443(hsd17b12) 111860853
LCM: 102348665 102362094(HSD17B12)
CMK: 103174968(hsd17b12)
CIN: 445663
SPU: 593779
APLC: 110981629
DME: Dmel_CG1444(spidey)
DER: 6551636
DPE: 6600780
DSI: Dsimw501_GD16868(Dsim_GD16868)
DWI: 6649310
DAZ: 108618449
DNV: 108655805
DHE: 111598159
MDE: 101898425
AAG: 5580011
AME: 725258
MPHA: 105833102
AEC: 105152599
ACEP: 105617361
PBAR: 105433741
HST: 105182204
DQU: 106748186
CFO: 105251419
LHU: 105668502
PGC: 109859341
OBO: 105280430
NVI: 100121752
MDL: 103569315
TCA: 660392
DPA: 109538015
NVL: 108559965
BMOR: 101744618
PMAC: 106714614
PRAP: 110993240
TNL: 113494127
PXY: 105386843
ZNE: 110833461
FCD: 110850806
TUT: 107360802
CEL: CELE_C06B3.4(stdh-1) CELE_C06B3.5(stdh-3) CELE_C56G2.6(let-767) CELE_F11A5.12(stdh-2) CELE_F25G6.5(stdh-4)
CBR: CBG11441 CBG19695(Cbr-let-767)
BMY: Bm1_45995
TSP: Tsp_02573
PCAN: 112558929
CRG: 105341564
MYI: 110454786
OBI: 106880401
LAK: 106169616
PDAM: 113668436
SPIS: 111331594
ATH: AT1G67730(KCR1)
LJA: Lj0g3v0295429.1(Lj0g3v0295429.1) Lj4g3v2717040.1(Lj4g3v2717040.1) Lj6g3v0585170.1(Lj6g3v0585170.1)
CANN: 107860712
NTO: 104087941
DOSA: Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299200-00(Os06g0299200) Os06t0299300-01(Os06g0299300) Os06t0300000-01(Os06g0300000)
ATS: 109733083(LOC109733083) 109733956(LOC109733956) 109733958(LOC109733958) 109736758(LOC109736758) 109743960(LOC109743960) 109744922(LOC109744922) 109745871(LOC109745871) 109746082(LOC109746082) 109746886(LOC109746886) 109747761(LOC109747761) 109755743(LOC109755743) 109756557(LOC109756557) 109765204(LOC109765204) 109765210(LOC109765210) 109766544(LOC109766544) 109766795(LOC109766795) 109768745(LOC109768745) 109771085(LOC109771085) 109772730(LOC109772730) 109773274(LOC109773274) 109773689(LOC109773689) 109779269(LOC109779269) 109781113(LOC109781113) 109781925(LOC109781925) 109782273(LOC109782273)
PPP: 112290473
APRO: F751_1671
SCE: YBR159W(IFA38)
ERC: Ecym_2565
NCS: NCAS_0B02360(NCAS0B02360)
NDI: NDAI_0C05330(NDAI0C05330)
TPF: TPHA_0L01460(TPHA0L01460)
TBL: TBLA_0H03430(TBLA0H03430)
TDL: TDEL_0B01260(TDEL0B01260)
KAF: KAFR_0E03020(KAFR0E03020)
PIC: PICST_79198(YBO9)
CAL: CAALFM_CR06070WA(CaO19.3859)
SLB: AWJ20_1871(IFA38)
NCR: NCU04462
NTE: NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
MGR: MGG_05096
MBE: MBM_06633
ANI: AN5861.2
ANG: ANI_1_488024(An02g03570)
CIM: CIMG_08188 CIMG_11390(CIMG04755)
PTE: PTT_14300
CNE: CNI00690
CNB: CNBH0660
ABP: AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: AGABI2DRAFT192460(AGABI2DRAFT_192460)
MGL: MGL_1839
DFA: DFA_11026
EHI: EHI_165070(127.t00009)
PYO: PY17X_0523800(PY05567)
PCB: PCHAS_052260(PC000268.05.0)
SPAR: SPRG_04210
TCR: 506219.40
BCEN: DM39_5665
BMK: DM80_3022
FLN: FLA_0019
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM.
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
DOI:10.1074/jbc.M205620200
  Sequence
[sce:YBR159W]
Reference
  Authors
Luu-The V, Tremblay P, Labrie F
  Title
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
  Journal
Mol Endocrinol 20:437-43 (2006)
DOI:10.1210/me.2005-0058
  Sequence
[hsa:51144]
Reference
  Authors
Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L
  Title
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
  Journal
Plant Physiol 150:1174-91 (2009)
DOI:10.1104/pp.109.137497
  Sequence
[ath:AT1G67730]
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