KEGG   ORTHOLOGY: K12705
Entry
K12705            Tight     KO                                     

Name
novO, couO
Definition
8-demethylnovobiocic acid C8-methyltransferase [EC:2.1.1.284]
Pathway
ko00401  Novobiocin biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12705  novO, couO; 8-demethylnovobiocic acid C8-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.284  8-demethylnovobiocic acid C8-methyltransferase
     K12705  novO, couO; 8-demethylnovobiocic acid C8-methyltransferase
Other DBs
RN: R06778 R10454
Genes
AG: AAF67508(novO) AAG29793(couO)
Reference
  Authors
Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L
  Title
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
  Journal
Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000
  Sequence
Reference
  Authors
Sattely ES, Fischbach MA, Walsh CT
  Title
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.
  Journal
Nat Prod Rep 25:757-93 (2008)
DOI:10.1039/b801747f
LinkDB

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