REACTION: R06778
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Entry
R06778 Reaction
Definition
5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate + 3-Amino-4,7-dihydroxycoumarin + ATP + 2 S-Adenosyl-L-methionine <=> Coumermic acid + AMP + Diphosphate + 2 S-Adenosyl-L-homocysteine
Equation
C20637
+
C12468
+
C00002
+ 2
C00019
<=>
C12479
+
C00020
+
C00013
+ 2
C00021
Comment
multi-step reaction
ligase, CouL
methyltransferase, CouO
Reaction class
RC00003
C00019_C00021
RC03149
C12479_C20637
RC03150
C12468_C12479
Pathway
rn00401
Novobiocin biosynthesis
rn01110
Biosynthesis of secondary metabolites
Orthology
K12705
8-demethylnovobiocic acid C8-methyltransferase [EC:
2.1.1.284
]
K12709
8-demethylnovobiocic acid synthase [EC:
6.3.1.15
]
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