KEGG   ORTHOLOGY: K14255Help
Entry
K14255                      KO                                     

Name
oxyT, ctcO, cts6
Definition
4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
Pathway
ko00253  Tetracycline biosynthesis
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14255  oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
   00253 Tetracycline biosynthesis
    K14255  oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.335  4-amino-anhydrotetracycline N4-methyltransferase
     K14255  oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase
BRITE hierarchy
Other DBs
RN: R09191 R09200 R11520 R11521
Genes
KAU: B6264_18530
AG: AAZ78343(oxyT) AEI98658(ctcO) BAA07388(cts6)
TaxonomyKoalaUniProt
Reference
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
Reference
  Authors
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J
  Title
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.
  Journal
J Am Chem Soc 130:6068-9 (2008)
DOI:10.1021/ja800951e
LinkDB All DBs

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