KEGG   REACTION: R01837
Entry
R01837                      Reaction                               
Name
3beta-hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
Definition
Dehydroepiandrosterone + NAD+ <=> Androstenedione + NADH + H+
Equation
C01227 + C00003 <=> C00280 + C00004 + C00080
Comment
NADP+ (see R01839)
Reaction class
RC00001  C00003_C00004
RC00146  C00280_C01227
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R01837  Dehydroepiandrosterone + NAD+ <=> Androstenedione + NADH + H+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R01837  Dehydroepiandrosterone + NAD+ <=> Androstenedione + NADH + H+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Other DBs
RHEA: 43935
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