KEGG   DRUG: Doxycycline hyclate
Entry
D02129                      Drug                                   

Name
Doxycycline hyclate (USP);
Doxycycline hydrochloride hydrate (JP17);
Doryx (TN);
Lymepak (TN);
Periostat (TN);
Vibra-tabs (TN)
Product
  Generic
DOXY 100(TM) DOXYCYCLINE (HF Acquisition Co LLC), DOXYCYCLINE HYCLATE (Lupin Pharmaceuticals), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (Amneal Pharmaceuticals NY LLC), DOXYCYCLINE HYCLATE (Amneal Pharmaceuticals NY LLC), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE (Cadila Healthcare Limited), DOXYCYCLINE (Chartwell RX LLC), DOXYCYCLINE HYCLATE (Denton Pharma), DOXYCYCLINE (DirectRX), DOXYCYCLINE (Direct_Rx), DOXY 100 (Fresenius Kabi USA), DOXY 100 (Fresenius Kabi USA), DOXY 100 (Fresenius Kabi USA), DOXY 100 (General Injectables & Vaccines), DOXYCYCLINE (General Injectables & Vaccines), DOXYCYCLINE (Mylan Institutional LLC), DOXYCYCLINE HYCLATE (Mylan Pharmaceuticals), DOXYCYCLINE HYCLATE (Proficient Rx LP), DOXYCYCLINE HYCLATE (RedPharm Drug), DOXYCYCLINE (Zydus Pharmaceuticals (USA)), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE HYCLATE (A-S Medication Solutions), DOXYCYCLINE (Acella Pharmaceuticals), DOXYCYCLINE HYCLATE (Actavis Pharma), DOXYCYCLINE HYCLATE (Actavis Pharma), DOXYCYCLINE HYCLATE (Ajanta Pharma Limited), DOXYCYCLINE HYCLATE (Ajanta Pharma Limited), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals Limited), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals Limited), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals Limited), DOXYCYCLINE HYCLATE (Alembic Pharmaceuticals Limited), DOXYCYCLINE HYCLATE (Alvogen), DOXYCYCLINE (American Health Packaging), DOXYCYCLINE HYCLATE (American Health Packaging), DOXYCYCLINE HYCLATE (Aphena Pharma Solutions - Tennessee), DOXYCYCLINE HYCLATE (Aphena Pharma Solutions - Tennessee), DOXYCYCLINE HYCLATE (Apotex Corp.), DOXYCYCLINE HYCLATE (Asclemed USA), DOXYCYCLINE HYCLATE (AvKARE), DOXYCYCLINE HYCLATE (AvPAK), DOXYCYCLINE HYCLATE (Bi-Coastal Pharma International), DOXYCYCLINE HYCLATE (Bi-Coastal Pharma International), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Bryant Ranch Prepack), DOXYCYCLINE HYCLATE (Cadila Healthcare Limited), DOXYCYCLINE HYCLATE (Cadila Healthcare Limited), DOXYCYCLINE HYCLATE (Cadila Healthcare Limited), DOXYCYCLINE (Cardinal Health), DOXYCYCLINE (Cardinal Health), DOXYCYCLINE HYCLATE (Changzhou Pharmaceutical Factory), DOXYCYCLINE HYCLATE (Changzhou Pharmaceutical Factory), DOXYCYCLINE HYCLATE (Contract Pharmacy Services-PA), DOXYCYCLINE HYCLATE (DIRECT RX), DOXYCYCLINE HYCLATE (DIRECT RX), DOXYCYCLINE HYCLATE (Denton Pharma), DOXYCYCLINE HYCLATE (Denton Pharma), DOXYCYCLINE HYCLATE (Denton Pharma), DOXYCYCLINE HYCLATE (Denton Pharma), DOXYCYCLINE HYCLATE (Direct_Rx), DOXYCYCLINE HYCLATE (EPIC PHARMA), DOXYCYCLINE HYCLATE (Epic Pharma), DOXYCYCLINE HYCLATE (Golden State Medical Supply), DOXYCYCLINE HYCLATE (Golden State Medical Supply), DOXYCYCLINE (Golden State Medical Supply), DOXYCYCLINE HYCLATE (Harris Pharmaceutical), DOXYCYCLINE HYCLATE (Harris Pharmaceutical), DOXYCYCLINE HYCLATE (Heritage Pharmaceuticals), DOXYCYCLINE HYCLATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), DOXYCYCLINE HYCLATE (Hikma Pharmaceuticals USA), DOXYCYCLINE HYCLATE (JG Pharma), TARGADOX (Journey Medical Corporation), DOXYCYCLINE HYCLATE (Lake Erie Medical DBA Quality Care Products LLC), DOXYCYCLINE HYCLATE (Lannett Company), DOXYCYCLINE HYCLATE (Larken Laboratories), DOXYCYCLINE HYCLATE (Lupin Pharmaceuticals), DOXYCYCLINE HYCLATE (Major Pharmaceuticals), DOXYCYCLINE (Major Pharmaceuticals), DOXYCYCLINE HYCLATE (Mayne Pharma), DOXYCYCLINE HYCLATE (Mayne Pharma), DOXYCYCLINE HYCLATE (Mayne Pharma), DOXYCYCLINE HYCLATE (McKesson Corporation dba SKY Packaging), MORGIDOX (Medimetriks Pharmaceuticals), DOXYCYCLINE HYCLATE (Medsource Pharmaceuticals), DOXYCYCLINE HYCLATE (Medsource Pharmaceuticals), DOXYCYCLINE HYCLATE (Mylan Pharmaceuticals), DOXYCYCLINE HYCLATE (Nostrum Laboratories), DOXYCYCLINE HYCLATE (Novel Laboratories), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE HYCLATE (NuCare Pharmaceuticals), DOXYCYCLINE (Oaklock), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PD-Rx Pharmaceuticals), DOXYCYCLINE HYCLATE (PURACAP LABORATORIES LLC DBA BLU PHARMACEUTICALS), DOXYCYCLINE HYCLATE (Preferred Pharmaceuticals), DOXYCYCLINE HYCLATE (Preferred Pharmaceuticals), DOXYCYCLINE HYCLATE (Preferred Pharmaceuticals), DOXYCYCLINE HYCLATE (Preferred Pharmaceuticals), DOXYCYCLINE HYCLATE (Proficient Rx LP), DOXYCYCLINE HYCLATE (Proficient Rx LP), DOXYCYCLINE HYCLATE (Proficient Rx LP), DOXYCYCLINE HYCLATE (Proficient Rx LP), DOXYCYCLINE HYCLATE (Proficient Rx LP), DOXYCYCLINE HYCLATE (Quality Care Products), DOXYCYCLATE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (REMEDYREPACK), DOXYCYCLINE HYCLATE (RPK Pharmaceuticals), DOXYCYCLINE HYCLATE (RedPharm Drug), DOXYCYCLINE HYCLATE (RedPharm Drug), DOXYCYCLINE HYCLATE (RedPharm Drug), DOXYCYCLINE HYCLATE (RedPharm Drug), DOXYCYCLINE HYCLATE (RedPharm Drug), DOXYCYCLINE HYCLATE (Solco Healthcare US LLC), DOXYCYCLINE HYCLATE (Sonoma Pharmaceuticals), DOXYCYCLINE (St Marys Medical Park Pharmacy), DOXYCYCLINE HYCLATE (St. Mary's Medical Park Pharmacy), DOXYCYCLINE HYCLATE (Sun Pharmaceutical Industries), DOXYCYCLINE HYCLATE (Sun Pharmaceutical Industries), DOXYCYCLINE HYCLATE (Viona Pharmaceuticals), DOXYCYCLINE HYCLATE (West-Ward Pharmaceuticals Corp), DOXYCYCLINE (West-Ward Pharmaceuticals Corp), DOXYCYCLINE HYCLATE (Zydus Pharmaceuticals (USA)), DOXYCYCLINE HYCLATE (Zydus Pharmaceuticals (USA)), DOXYCYCLINE HYCLATE (direct rx), VIBRAMYCIN (Advanced Rx Pharmacy of Tennessee)
Formula
(C22H24N2O8)2. 2HCl. C2H6O. H2O
Exact mass
1024.3123
Mol weight
1025.8747
Structure
Class
Antibacterial
 DG01197  Tetracycline antibiotic
Remark
Therapeutic category: 6152
ATC code: A01AB22 J01AA02
Chemical structure group: DG00008
Product (DG00008): D00307<US> D02129<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
  Disease
Rocky Mountain spotted fever [DS:H00323]
Typhus fever [DS:H00322]
Q fever [DS:H00310]
Rickettsial pox [DS:H02379]
Lymphogranuloma venereum [DS:H00348]
Granuloma inguinale [DS:H01415]
Gonorrhea [DS:H00315]
Chancroid [DS:H00305]
Psittacosis [DS:H00350]
Relapsing fever [DS:H00427]
Plague [DS:H00297]
Tularemia [DS:H00312]
Cholera [DS:H00110]
Campylobacter fetus infections [DS:H00321]
Brucellosis [DS:H00325]
Bartonellosis [DS:H00326]
Trachoma [DS:H00349]
Anthrax [DS:H00328]
Syphilis [DS:H00354]
Yaws [DS:H01318]
Listeriosis [DS:H00332]
Vincent's infection [DS:H01440]
Actinomycosis [DS:H01325]
Amebiasis [DS:H00360]
Malaria [DS:H00361]
Lyme disease [DS:H00353]
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07019  Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB22 Doxycycline
      D02129  Doxycycline hyclate (USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA02 Doxycycline
      D02129  Doxycycline hyclate (USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Doxycycline
    D02129  Doxycycline hyclate (USP)
 Dental and Oral Agents
  Doxycycline
   D02129  Doxycycline hyclate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D02129  Doxycycline hyclate (USP); Doxycycline hydrochloride hydrate (JP17)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02129  Doxycycline hydrochloride hydrate
  D02129  Doxycycline hydrochloride tablets
Other DBs
CAS: 24390-14-5
PubChem: 7849190
ChEBI: 34730
ChEMBL: CHEMBL3989740
DrugBank: DB00254
LigandBox: D02129
NIKKAJI: J1.592.539F
LinkDB
KCF data

ATOM        70
            1   C1a C    37.7489  -12.8084
            2   C1b C    38.9644  -12.1088
            3   O1a O    40.1800  -12.8084
            4   C1y C    27.9308  -15.6197
            5   C1z C    27.9590  -16.9683
            6   C1y C    29.1130  -14.9598
            7   C1y C    26.7715  -14.9311
            8   C2y C    26.7429  -17.6341
            9   C5x C    29.0729  -17.6626
            10  C2y C    30.2664  -15.6541
            11  C1y C    25.5893  -15.5968
            12  C2y C    25.6479  -16.9510
            13  O1a O    26.7372  -18.9940
            14  C2y C    30.2549  -17.0028
            15  O5x O    29.0252  -19.0227
            16  O1a O    31.4603  -14.9943
            17  C1y C    24.4188  -14.9138
            18  C5x C    24.4073  -17.6283
            19  C5a C    31.4200  -17.7029
            20  C8y C    23.2479  -15.5854
            21  C8y C    23.2422  -16.9453
            22  O5x O    24.4073  -18.9824
            23  N1a N    32.6080  -17.0372
            24  O5a O    31.4482  -19.0628
            25  C8x C    22.0598  -14.9081
            26  C8y C    22.0657  -17.6226
            27  C8x C    20.8891  -15.5910
            28  C8x C    20.8891  -16.9510
            29  O1a O    22.0657  -18.9824
            30  C1a C    24.4240  -13.2010
            31  N1c N    29.1354  -12.7712
            32  C1a C    30.3355  -12.1044
            33  C1a C    27.9578  -12.0654
            34  O1a O    26.7614  -13.2147
            35  O1a O    27.9056  -18.3392
            36  X   Cl   38.8478  -15.3293
            37  O0  O    39.5477  -17.8490
            38  C1y C    27.9308  -15.6197
            39  C1z C    27.9590  -16.9683
            40  C2y C    26.7429  -17.6341
            41  C2y C    25.6479  -16.9510
            42  C5x C    24.4073  -17.6283
            43  C8y C    23.2422  -16.9453
            44  C8y C    22.0657  -17.6226
            45  C8x C    20.8891  -16.9510
            46  C8x C    20.8891  -15.5910
            47  C8x C    22.0598  -14.9081
            48  C8y C    23.2479  -15.5854
            49  C1y C    24.4188  -14.9138
            50  C1y C    25.5893  -15.5968
            51  C1y C    26.7715  -14.9311
            52  O1a O    26.7614  -13.2147
            53  C1a C    24.4240  -13.2010
            54  O1a O    22.0657  -18.9824
            55  O5x O    24.4073  -18.9824
            56  O1a O    26.7372  -18.9940
            57  C5x C    29.0729  -17.6626
            58  C2y C    30.2549  -17.0028
            59  C5a C    31.4200  -17.7029
            60  N1a N    32.6080  -17.0372
            61  O5a O    31.4482  -19.0628
            62  C2y C    30.2664  -15.6541
            63  O1a O    31.4603  -14.9943
            64  C1y C    29.1130  -14.9598
            65  N1c N    29.1354  -12.7712
            66  C1a C    30.3355  -12.1044
            67  C1a C    27.9578  -12.0654
            68  O5x O    29.0252  -19.0227
            69  O1a O    27.9056  -18.3392
            70  X   Cl   38.8478  -15.3293
BOND        72
            1     1   2 1
            2     2   3 1
            3     8  12 2
            4     8  13 1
            5     9  14 1
            6     9  15 2
            7    10  16 1
            8    11  17 1
            9    12  18 1
            10   14  19 1
            11   17  20 1
            12   18  21 1
            13   18  22 2
            14   19  23 1
            15   19  24 2
            16   20  25 1
            17   21  26 1
            18   25  27 2
            19   26  28 2
            20   26  29 1
            21   10  14 2
            22   11  12 1
            23   20  21 2
            24   27  28 1
            25   17  30 1 #Down
            26    6  31 1 #Down
            27    4   5 1
            28   31  32 1
            29    4   6 1
            30   31  33 1
            31    4   7 1
            32    5   8 1
            33    5   9 1
            34    7  34 1 #Down
            35    6  10 1
            36    5  35 1 #Down
            37    7  11 1
            38   40  41 2
            39   40  56 1
            40   57  58 1
            41   57  68 2
            42   62  63 1
            43   50  49 1
            44   41  42 1
            45   58  59 1
            46   49  48 1
            47   42  43 1
            48   42  55 2
            49   59  60 1
            50   59  61 2
            51   48  47 1
            52   43  44 1
            53   47  46 2
            54   44  45 2
            55   44  54 1
            56   62  58 2
            57   50  41 1
            58   48  43 2
            59   46  45 1
            60   49  53 1 #Down
            61   64  65 1 #Down
            62   38  39 1
            63   65  66 1
            64   38  64 1
            65   65  67 1
            66   38  51 1
            67   39  40 1
            68   39  57 1
            69   51  52 1 #Down
            70   64  62 1
            71   39  69 1 #Down
            72   51  50 1
BRACKET     1    20.0900  -19.8800   20.0900  -10.9900
            1    34.3700  -10.9900   34.3700  -19.8800
            1  2
 ORIGINAL  1    4   5   8  12  18  21  26  28  27  25  20  17  11  35   7  36
            1   30  29  22  13   9  14  19  23  24  10  16   6  31  32  33  15
            1   37  34
 REPEAT    1   40  41  42  43  44  45  46  47  48  49  50  51  52  53  54  55
            1   56  57  58  59  60  61  62  63  64  65  66  67  68  69  70  71
            1   72  73
            2    37.1700  -16.1700   37.1700  -14.4200
            2    39.7600  -14.4200   39.7600  -16.1700
            2  2
 ORIGINAL  2   38
 REPEAT    2   74

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