KEGG   DRUG: Pregabalin
Entry
D02716                      Drug                                   

Name
Pregabalin (JAN/USAN/INN);
Lyrica (TN)
Product
LYRICA (DirectRX), LYRICA (Aphena Pharma Solutions - Tennessee), LYRICA (Aphena Pharma Solutions - Tennessee), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Bryant Ranch Prepack), LYRICA (Cardinal Health), PREGABALIN (DIRECT RX), LYRICA (DIRECT RX), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (Lake Erie Medical DBA Quality Care Products LLC), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA (PD-Rx Pharmaceuticals), LYRICA CR (Parke-Davis Div of Pfizer), LYRICA (Parke-Davis Div of Pfizer), LYRICA (Quality Care Products), LYRICA (Quality Care Products), LYRICA (Quality Care Products), LYRICA (REMEDYREPACK), LYRICA (REMEDYREPACK), LYRICA CR (U.S. Pharmaceuticals), LYRICA (U.S. Pharmaceuticals), LYRICA (Unit Dose Services)
  Generic
PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), PREGABALIN (A-S Medication Solutions), LYRICA (ADVANCED RX PHARMACY OF TENNESSEE), PREGABALIN (Actavis Pharma), PREGABALIN (Alembic Pharmaceuticals), PREGABALIN (Alembic Pharmaceuticals Limited), PREGABALIN (American Health Packaging), PREGABALIN (Amneal Pharmaceuticals NY LLC), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Aphena Pharma Solutions - Tennessee), PREGABALIN (Ascend Laboratories), PREGABALIN (Ascend Laboratories), PREGABALIN (Ascend Laboratories), PREGABALIN (Asclemed USA), PREGABALIN (Asclemed USA), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (Bryant Ranch Prepack), PREGABALIN (CELLTRION USA), PREGABALIN (Camber Pharmaceuticals), PREGABALIN (Cardinal Health), PREGABALIN (Cipla USA), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Direct_Rx), PREGABALIN (Dr.Reddys Laboratories), PREGABALIN (Exelan Pharmaceuticals), PREGABALIN (Golden State Medical Supply), PREGABALIN (Greenstone LLC), PREGABALIN (MSN LABORATORIES PRIVATE LIMITED), PREGABALIN (Major Pharmaceuticals), PREGABALIN (Novadoz Pharmaceuticals LLC), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Preferred Pharmaceuticals), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Proficient Rx LP), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (Quality Care Products), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (REMEDYREPACK), PREGABALIN (Rising Pharmaceuticals), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (St. Mary's Medical Park Pharmacy), PREGABALIN (Sun Pharmaceutical Industries), PREGABALIN (Teva Pharmaceuticals USA), LYRICA (Advanced Rx Pharmacy of Tennessee), LYRICA (Advanced Rx Pharmacy of Tennessee), LYRICA (Advanced Rx Pharmacy of Tennessee), LYRICA (Advanced Rx Pharmacy of Tennessee), LYRICA (Advanced Rx Pharmacy of Tennessee), PREGABALIN CAPSULES, CV (Cipla USA)
Formula
C8H17NO2
Exact mass
159.1259
Mol weight
159.2261
Structure
Class
Neuropsychiatric agent
 DG02037  GABA mimetic antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01574  Calcium channel alpha-2 delta blocker
Remark
Therapeutic category: 1190
ATC code: N03AX16
Product: D02716<JP/US>
Efficacy
Anticonvulsant, Pain relief
  Disease
Diabetic peripheral neuropathy [DS:H01459]
Postherpetic neuralgia [DS:H01624]
Fibromyalgia [DS:H01636]
Comment
GABA [CPD:C00334] analog
Target
  Pathway
hsa04010  MAPK signaling pathway
Interaction
Structure map
map07033  Anticonvulsants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX16 Pregabalin
      D02716  Pregabalin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   GABA Agents, Other
    Pregabalin
     D02716  Pregabalin (JAN/USAN/INN)
 Central Nervous System Agents
  Fibromyalgia Agents
   Pregabalin
    D02716  Pregabalin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D02716  Pregabalin (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA2D
     D02716  Pregabalin (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02716
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02716
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02716
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02716
Other DBs
CAS: 148553-50-8
PubChem: 17396883
ChEBI: 64356
ChEMBL: CHEMBL1059
DrugBank: DB00230
LigandBox: D02716
NIKKAJI: J702.547E
LinkDB
KCF data

ATOM        11
            1   C1c C    20.4400  -16.3100
            2   C1b C    21.6300  -17.0800
            3   C6a C    22.8900  -16.3100
            4   O6a O    24.0100  -17.0800
            5   O6a O    22.8900  -14.9800
            6   C1b C    19.2500  -17.0100
            7   N1a N    18.0347  -16.3149
            8   C1b C    20.4698  -14.9103
            9   C1c C    19.2508  -14.1713
            10  C1a C    18.0363  -14.8379
            11  C1a C    19.2816  -12.7404
BOND        10
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     3   5 2
            5     1   6 1 #Up
            6     6   7 1
            7     1   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 1

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