KEGG ORTHOLOGY: K04858

ORTHOLOGY: K04858

Entry

K04858                      KO

Symbol

CACNA2D1

Name

voltage-dependent calcium channel alpha-2/delta-1

Pathway

map04010

MAPK signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04921

Oxytocin signaling pathway

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00606

Early infantile epileptic encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
   04261 Adrenergic signaling in cardiomyocytes
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
   05414 Dilated cardiomyopathy
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04858  CACNA2D1; voltage-dependent calcium channel alpha-2/delta-1

Other DBs

GO:

0005245

TC:

8.A.18.1

Genes

HSA:	781(CACNA2D1)

PTR:	463504(CACNA2D1)

PPS:	100982794(CACNA2D1)

GGO:	101128490(CACNA2D1)

PON:	100171724(CACNA2D1)

PPYG:

129040537(CACNA2D1)

NLE:	100595072(CACNA2D1)

HMH:	116814159(CACNA2D1)

SSYN:

129484809(CACNA2D1)

MCC:	708215(CACNA2D1)

MCF:	102131750(CACNA2D1)

MTHB:

126949899

MNI:	105475402(CACNA2D1)

CSAB:

103226639(CACNA2D1)

CATY:

105583235(CACNA2D1)

PANU:

101018169(CACNA2D1)

TGE:	112621007(CACNA2D1)

MLEU:

105543929(CACNA2D1)

RRO:	104681577(CACNA2D1)

RBB:	108536908(CACNA2D1)

TFN:	117072561(CACNA2D1)

PTEH:

111552459(CACNA2D1)

CANG:

105501674(CACNA2D1)

CJC:	100385605(CACNA2D1)

SBQ:	101053043(CACNA2D1)

CIMI:

108300338(CACNA2D1)

ANAN:

105726650(CACNA2D1)

CSYR:

103249923(CACNA2D1)

MMUR:

105879323(CACNA2D1)

LCAT:

123647164(CACNA2D1)

OGA:	100963985(CACNA2D1)

MMU:	12293(Cacna2d1)

MCAL:

110295349(Cacna2d1)

MPAH:

110316372(Cacna2d1)

RNO:	25399(Cacna2d1)

MCOC:

116097487(Cacna2d1)

ANU:	117720397(Cacna2d1)

ASYL:

127678288(Cacna2d1)

MUN:	110541459(Cacna2d1)

CGE:	100764769(Cacna2d1)

MAUA:

101835530(Cacna2d1)

PROB:

127214540(Cacna2d1) 127218679

PLEU:

114687339(Cacna2d1)

MORG:

121434621 121459135

MFOT:

126500114

AAMP:

119803844(Cacna2d1)

NGI:	103730725(Cacna2d1)

HGL:	101708369(Cacna2d1)

CPOC:

100728887(Cacna2d1)

CCAN:

109681780(Cacna2d1)

DORD:

105992916(Cacna2d1)

DSP:	122111799(Cacna2d1)

DMER:

138809624(Cacna2d1)

PLOP:

125346954(Cacna2d1)

NCAR:

124990321

MMMA:

107144442(Cacna2d1)

ITI:	101978444(Cacna2d1)

OCU:	100009105(CACNA2D1)

OPI:	101516203(CACNA2D1)

TUP:	102482417(CACNA2D1)

GVR:	103586524(CACNA2D1)

CFA:	610342(CACNA2D1)

CLUD:

112661473(CACNA2D1)

VVP:	112925398(CACNA2D1)

VLG:	121471833(CACNA2D1)

NPO:	129494126(CACNA2D1)

AML:	100463812(CACNA2D1)

UMR:	103658778(CACNA2D1)

UAH:	113259255(CACNA2D1)

UAR:	123789347(CACNA2D1)

ELK:

111155265

LLV:

125080441

MPUF:

101678500(CACNA2D1)

MNP:	132015988(CACNA2D1)

MLK:	131829312(CACNA2D1)

NVS:	122904763(CACNA2D1)

ORO:	101373490(CACNA2D1)

EJU:	114220710(CACNA2D1)

ZCA:	113911321(CACNA2D1)

MLX:	118020687(CACNA2D1)

NSU:	110580141(CACNA2D1)

LWW:	102741417(CACNA2D1)

FCA:	101099450(CACNA2D1)

PYU:	121028792(CACNA2D1)

PCOO:

112866861(CACNA2D1)

PBG:	122487824(CACNA2D1)

PVIV:

125160370(CACNA2D1)

LRUF:

124524101

LGF:	123606385(CACNA2D1)

AJU:

106975662

PTG:	102951633(CACNA2D1)

PPAD:

109268153(CACNA2D1)

PUC:

125929852

PLEZ:

122206911(CACNA2D1)

HHV:	120221165(CACNA2D1)

BTA:	282608(CACNA2D1)

BOM:	102268507(CACNA2D1)

BIU:	109557331(CACNA2D1)

BBUB:

102406537(CACNA2D1)

BBIS:

104994517(CACNA2D1)

CHX:	102183035(CACNA2D1)

OAS:	101123550(CACNA2D1)

BTAX:

128046666(CACNA2D1)

CSUM:

138080098(CACNA2D1)

ODA:	120878115(CACNA2D1)

CCAD:

122438248(CACNA2D1)

MREE:

136171221(CACNA2D1)

OVR:	110131436(CACNA2D1)

MBEZ:

129552334(CACNA2D1)

SSC:	397377(CACNA2D1)

CFR:	102520107(CACNA2D1)

CBAI:

105062378(CACNA2D1)

CDK:	105087345(CACNA2D1)

VPC:	102532132(CACNA2D1)

BACU:

103020121(CACNA2D1)

BMUS:

118900675(CACNA2D1)

LVE:	103082365(CACNA2D1)

OOR:	101273913(CACNA2D1)

LALB:

132524786(CACNA2D1)

GMF:	115840914(CACNA2D1)

DDP:	132430961(CACNA2D1)

DLE:	111164625(CACNA2D1)

PCAD:

102988187(CACNA2D1)

PSIU:

116759402(CACNA2D1)

PPHC:

136128089(CACNA2D1)

NASI:

112414506

ECB:	100057533(CACNA2D1)

EPZ:	103560846(CACNA2D1)

EAI:	106840179(CACNA2D1)

MYB:	102238945(CACNA2D1)

MYD:	102774068(CACNA2D1)

MMYO:

118666272(CACNA2D1)

MLF:	102440990(CACNA2D1)

MDT:	132242889(CACNA2D1)

MYUM:

139016306(CACNA2D1)

PKL:	118714358(CACNA2D1)

EFUS:

103293241(CACNA2D1)

MNA:	107527170(CACNA2D1)

DRO:	112303467(CACNA2D1)

SHON:

119000986(CACNA2D1)

AJM:	119044939(CACNA2D1)

PDIC:

114507533(CACNA2D1)

PHAS:

123811367(CACNA2D1)

MMF:	118620125(CACNA2D1)

PPAM:

129063313(CACNA2D1)

HAI:	109392343(CACNA2D1)

RFQ:	117012429(CACNA2D1)

PALE:

102888058(CACNA2D1)

PGIG:

120591750(CACNA2D1)

PVP:

105295536

RAY:	107501281(CACNA2D1)

MJV:	108409008(CACNA2D1)

TOD:	119250335(CACNA2D1)

SARA:

101544756(CACNA2D1)

SFUM:

130027729(CACNA2D1)

SETR:

126013608(CACNA2D1)

LAV:	100676022(CACNA2D1)

TMU:

101345222

ETF:	101641825(CACNA2D1)

DNM:	101426221(CACNA2D1)

MDO:	100012746(CACNA2D1)

GAS:	123249992(CACNA2D1)

SHR:	100915174(CACNA2D1)

AFZ:

127538102

PCW:	110206948(CACNA2D1)

TVP:	118850038(CACNA2D1)

PBRV:

138175717 138175974

MLAO:

141494189(CACNA2D1)

OAA:	100074856(CACNA2D1)

TACU:

119920772(CACNA2D1)

GGA:	768444(CACNA2D1)

PCOC:

116227844(CACNA2D1)

CJO:	107321641(CACNA2D1)

TPAI:

128079548(CACNA2D1)

LMUT:

125687995(CACNA2D1)

NMEL:

110392308(CACNA2D1)

APLA:

101793350(CACNA2D1)

ACYG:

106035544(CACNA2D1)

CATA:

118249509(CACNA2D1)

AFUL:

116490704(CACNA2D1)

TGU:	100227443(CACNA2D1)

LSR:	110477395(CACNA2D1)

SCAN:

103813738(CACNA2D1)

PMOA:

120509307(CACNA2D1)

OTC:	121336290(CACNA2D1)

PRUF:

121357357(CACNA2D1)

ATRC:

139588527(CACNA2D1)

GFR:	102042376(CACNA2D1)

FAB:	101820977(CACNA2D1)

OMA:	130265610(CACNA2D1)

PHI:	102112187(CACNA2D1)

PMAJ:

107204625(CACNA2D1)

CCAE:

111923300(CACNA2D1)

CCW:	104686893(CACNA2D1)

CBRC:

103612024(CACNA2D1)

ACOE:

138121705(CACNA2D1)

ETL:	114058725(CACNA2D1)

ZAB:	102068889(CACNA2D1)

ZLE:	135442769(CACNA2D1)

SVG:	106857396(CACNA2D1)

MMEA:

130579834(CACNA2D1)

HRT:	120752385(CACNA2D1)

CCIC:

134043412(CACNA2D1)

FPG:	101917007(CACNA2D1)

FCH:	102059307(CACNA2D1)

CCRI:

104158630(CACNA2D1)

NNT:	104402726(CACNA2D1)

SHAB:

115605351(CACNA2D1)

ACUN:

113487405(CACNA2D1)

TALA:

104363201(CACNA2D1)

ACHC:

115341249(CACNA2D1)

HALD:

104321678(CACNA2D1)

HLE:	104840178(CACNA2D1)

AGEN:

126044352

HHAR:

128142758(CACNA2D1)

GCL:

127014860

CSTI:

104562208(CACNA2D1)

DPUB:

104299801(CACNA2D1)

PPUS:

135174908(CACNA2D1)

BRHI:

104492037(CACNA2D1)

EGZ:	104132378(CACNA2D1)

NNI:	104010753(CACNA2D1)

PCAO:

104044803(CACNA2D1)

PADL:

103920600(CACNA2D1)

AFOR:

103904168(CACNA2D1)

FGA:	104079504(CACNA2D1)

CBOY:

140650306(CACNA2D1)

CLV:	102088083(CACNA2D1)

CNIC:

135991001(CACNA2D1)

MUI:

104548701

PGUU:

104467336(CACNA2D1)

CMAC:

104486589(CACNA2D1)

CUCA:

104066037(CACNA2D1)

TEO:	104379136(CACNA2D1)

OHA:	104337640(CACNA2D1)

ACAR:

104520442(CACNA2D1)

CPEA:

104392408(CACNA2D1)

CVF:	104284579(CACNA2D1)

RTD:	128907306(CACNA2D1)

CRID:

134510350(CACNA2D1)

AROW:

112967579(CACNA2D1)

NPD:	112958375(CACNA2D1)

TGT:	104574729(CACNA2D1)

DNE:	112980305(CACNA2D1)

SCAM:

104144708(CACNA2D1)

ASN:	102386090(CACNA2D1)

AMJ:	102565821(CACNA2D1)

CPOO:

109315771(CACNA2D1)

GGN:	109292184(CACNA2D1)

PSS:	102450076(CACNA2D1)

CMY:	102938285(CACNA2D1)

CCAY:

125630484(CACNA2D1)

DCC:	119841581(CACNA2D1)

CPIC:

101946496(CACNA2D1)

TST:	117874908(CACNA2D1)

CABI:

116836200(CACNA2D1)

MRV:	120394404(CACNA2D1)

ACS:	100566428(cacna2d1)

ASAO:

132776532(CACNA2D1)

PVT:	110077205(CACNA2D1)

SUND:

121930397(CACNA2D1)

PBI:	103064448(CACNA2D1)

CTIG:

120312564(CACNA2D1)

PGUT:

117675801

PCAE:

139319524(CACNA2D1)

APRI:

131201691(CACNA2D1)

PTEX:

113436564(CACNA2D1)

NSS:	113412330(CACNA2D1)

VKO:	123020042(CACNA2D1)

PMUA:

114606019(CACNA2D1)

PRAF:

128422826(CACNA2D1)

ZVI:	118090918(CACNA2D1)

HCG:	128326240(CACNA2D1)

GJA:	107124567(CACNA2D1)

STOW:

125435401(CACNA2D1)

EMC:	129336073(CACNA2D1)

XLA:	108711204(cacna2d1.L) 108713061(cacna2d1.S)

XTR:	100036724(cacna2d1)

NPR:	108792727(CACNA2D1)

RTEM:

120931732(CACNA2D1)

ACAT:

141131832(CACNA2D1)

BBUF:

120983036(CACNA2D1)

BGAR:

122927843(CACNA2D1)

DTC:	141054128(CACNA2D1)

PWL:	138287820(CACNA2D1)

MUO:	115479265(CACNA2D1)

GSH:	117366914(CACNA2D1)

DRE:	101882457 561434(cacna2d1a)

SRX:	107723934 107732991 107738419 107738810

SANH:

107672590 107673139 107695910 107699066

SGH:	107559841 107563411(cacna2d1) 107590440

CCAR:

109065183 109070518 109109723

CAUA:

113048112 113062550 113073053 113079824 113118203

CGIB:

127934749 127956800 127974291 127977265

PTET:

122343507(cacna2d1a) 122363109

LROH:

127163798(cacna2d1a) 127180851

GRF:	141333734(cacna2d1a) 141345347

OMC:	131524152 131538580(cacna2d1a)

PPRM:

120462007 120476968(cacna2d1a)

RKG:	130072221(cacna2d1a) 130094860

MAMB:

125246166(cacna2d1a) 125253992

CIDE:

127500200 127510912

CERY:

137022919 137024487(cacna2d1a)

MASI:

127417060 127434833 127436773 127455820

TROS:

130547752(cacna2d1a) 130562522

TDW:	130420600(cacna2d1a) 130435603

MANU:

129418742 129431727(cacna2d1a)

PDAB:

135749924 135773761

IPU:

108264659

IFU:

128606937

PHYP:

113534270(cacna2d1)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:	134313171(cacna2d1a) 134323335

AMEX:

103027187(cacna2d1a) 103044147

CMAO:

118812078(cacna2d1a) 118817770

EEE:	113577182 113588287

CHAR:

105889635(cacna2d1a) 105910328

SPIL:

134062430(cacna2d1a) 134094268

TRU:	101064543(cacna2d1) 101079089

TFS:	130518961(cacna2d1a) 130535708

TNG:	GSTEN00020826G001 GSTEN00035534G001

LCO:	104918121(cacna2d1) 104918796

NCC:	104952157 104958231

TBEN:

117484974 117491237

CGOB:

115009736(cacna2d1) 115028087

PGEO:

117448686 117468436

GACU:

117537323 117545743

EMAC:

134879173(cacna2d1a) 134883824

ELY:	117249651(cacna2d1a) 117262199

EFO:	125882507(cacna2d1a) 125887227

PLEP:

121950340 121961115(cacna2d1a)

SLUC:

116045663 116060044(cacna2d1a)

ECRA:

117938675(cacna2d1a) 117948720

ESP:	116673091 116694723

PFLV:

114549821 114559808

GAT:	120808765 120817980

PPUG:

119196383 119210570

AFB:	129108113 129112268

CLUM:

117726077(cacna2d1a) 117732029

PSWI:

130195737 130200419

CANA:

137791884 137803955

CVE:	137877475(cacna2d1a) 137881191

MSAM:

119894006 119918165(cacna2d1a)

SCHU:

122871350 122875527

CUD:	121505378 121515429

SPUL:

138599319 138612435

LMIX:

132956098(cacna2d1a) 132972399

ALAT:

119025044 119032573(cacna2d1a)

ASTR:

137589113 137594046

MZE:	101476728(cacna2d1) 101486293

ONL:	100705035(cacna2d1) 100705144

OAU:	116309808(cacna2d1a) 116318275

OLA:	101156213 101164397(cacna2d1)

OML:	112152678 112154516

CSAI:

133424606 133444303

XMA:	102232366 102238041

XCO:	114133417 114160855

XHE:	116707984(cacna2d1) 116736692

PRET:

103459225 103465999(cacna2d1)

PFOR:

103133825(cacna2d1) 103146204

PLAI:

106944868 106964832(cacna2d1)

PMEI:

106915080 106922236

GAF:	122826393(cacna2d1a) 122835732

PPRL:

129375519

CVG:	107085985 107099205

CTUL:

119773619 119789722(cacna2d1a)

GMU:	124856582 124882862

NFU:	107385644 107388870(cacna2d1)

KMR:	108230132 108235077(cacna2d1a)

ALIM:

106514761 106520335(cacna2d1)

NWH:	119416037 119428490(cacna2d1a)

AOCE:

111564003(cacna2d1a) 111564876

EJA:	138206344 138207496(cacna2d1a)

BFRE:

138621957(cacna2d1a) 138628222

MCEP:

124999775(cacna2d1a) 125015341

CSEM:

103380101 103382776

POV:	109624050(cacna2d1) 109632696

SSEN:

122766290(cacna2d1a) 122775663

SSOE:

131456144(cacna2d1a) 131470240

HHIP:

117757218(cacna2d1a) 117762737

HSP:	118102011(cacna2d1a) 118109924

PPLT:

128428928 128445085

SMAU:

118289276 118315579

LCF:	108875137 108879646

SDU:	111224485 111228383(cacna2d1)

SLAL:

111653379 111671920

XGL:	120793255 120799453(cacna2d1a)

HCQ:	109523795 109526841

SSCV:

125970198 125992026(cacna2d1a)

SBIA:

133493395(cacna2d1a) 133502180

PEE:	133396938(cacna2d1a) 133403146

PTAO:

133471884(cacna2d1a) 133477886

BPEC:

110161913(cacna2d1) 110166803

ENY:	140348520 140368163(cacna2d1a)

MALB:

109959825 109967519(cacna2d1)

BSPL:

114857729 114862133(cacna2d1a)

SJO:	128358351 128385197

SSCO:

133981458 134004214(cacna2d1a)

GMH:	115532118 115551161

SASA:

106561208 106573448 106576572

STRU:

115152047 115180504 115197760 115199102

OTW:	112219241 112245181 121843114

OMY:	110499865 110499867 110501950 110521553

OGO:	124016976 124036170

ONE:	115109800 115125157(cacna2d1)

OKI:	109866961 109879069 109879081

OKE:	118396257 118401180

OMM:	135509304 135516599

OCLA:

139393227 139416083

SALP:

111962521

SNH:	120031842 120050077 120053242 120065854

CCLU:

121531951 121543412 121549722 121577445

ELS:	105018430 105020378

OEP:	134020648 134037440

SFM:	108921141(cacna2d1) 108936376

PKI:	111833289 111846161(cacna2d1)

AANG:

118219259 118232093

AROT:

135245433 135259150

CCOG:

133118893(cacna2d1a) 133135728

LOC:	102697890(cacna2d1)

PSPA:

121318192 121319909

ARUT:

117415040 117419874

PSEX:

120534138

LCM:	102355436(CACNA2D1)

CMK:

RTP:

CPLA:

HOC:

LERI:

HAKA:

CIN:

SCLV:

SPU:

LPIC:

AJJ:

ARUN:

AAMU:

AFIL:

SKO:

DPX:	DAPPUDRAFT_324542

DMK:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

PPOI:

DSV:

RSAN:

RMP:

CSCU:

PTEP:

ABRU:

UDV:

SDM:	118198908 118204800

PVUL:

HASI:

HCRA:

PMAX:

RPHI:

ATEN:

AMIL:

MCAZ:

MFOO:

DGT:

XEN:

HMG:

Reference

PMID:22678293

Authors

Hoppa MB, Lana B, Margas W, Dolphin AC, Ryan TA

Title

alpha2delta expression sets presynaptic calcium channel abundance and release probability.

Journal

Nature 486:122-5 (2012)
DOI:10.1038/nature11033

Sequence

[hsa:781]

LinkDB

DBGET integrated database retrieval system