Homo sapiens (human): 781
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Entry
781 CDS
T01001
Symbol
CACNA2D1, CACNA2, CACNL2A, CCHL2A, DEE110, LINC01112, lncRNA-N3, MHS3
Name
(RefSeq) voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 preproprotein
KO
K04858
voltage-dependent calcium channel alpha-2/delta-1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04260
Cardiac muscle contraction
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04921
Oxytocin signaling pathway
hsa05410
Hypertrophic cardiomyopathy
hsa05412
Arrhythmogenic right ventricular cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06528
Calcium signaling
Element
N01637
Ca2+ entry, Voltage-gated Ca2+ channel
N01638
Skeletal-type VGCC-RYR signaling
N01639
Cardiac-type VGCC-RYR signaling
Disease
H00606
Early infantile epileptic encephalopathy
Drug target
Gabapentin (
DG01245
):
D00332
<JP/US>
D09539
<JP/US>
Mirogabalin (
DG02947
):
D10790
<JP>
D11203
Pregabalin:
D02716
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
781 (CACNA2D1)
09150 Organismal Systems
09152 Endocrine system
04921 Oxytocin signaling pathway
781 (CACNA2D1)
09153 Circulatory system
04260 Cardiac muscle contraction
781 (CACNA2D1)
04261 Adrenergic signaling in cardiomyocytes
781 (CACNA2D1)
09160 Human Diseases
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
781 (CACNA2D1)
05412 Arrhythmogenic right ventricular cardiomyopathy
781 (CACNA2D1)
05414 Dilated cardiomyopathy
781 (CACNA2D1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04040 Ion channels [BR:
hsa04040
]
781 (CACNA2D1)
Ion channels [BR:
hsa04040
]
Voltage-gated cation channels
Calcium channel, voltage-gated (Cav)
781 (CACNA2D1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
VGCC_alpha2
VWA_N
CACHD1_middle
VWA
VWA_3
VWA_2
dCache_1
MCP-like_PDC_1
PM1201
IFN-gamma
Motif
Other DBs
NCBI-GeneID:
781
NCBI-ProteinID:
NP_001353796
OMIM:
114204
HGNC:
1399
UniProt:
P54289
Structure
PDB
PDBj
LinkDB
All DBs
Position
7:complement(81946444..82443956)
Genome browser
AA seq
1103 aa
AA seq
DB search
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL
NT seq
3312 nt
NT seq
+upstream
nt +downstream
nt
atggctgctggctgcctgctggccttgactctgacacttttccaatctttgctcatcggc
ccctcgtcggaggagccgttcccttcggccgtcactatcaaatcatgggtggataagatg
caagaagaccttgtcacactggcaaaaacagcaagtggagtcaatcagcttgttgatatt
tatgagaaatatcaagatttgtatactgtggaaccaaataatgcacgccagctggtagaa
attgcagccagggatattgagaaacttctgagcaacagatctaaagccctggtgcgcctg
gcattggaagcggagaaagttcaagcagctcaccagtggagagaagattttgcaagcaat
gaagttgtctactacaatgcaaaggatgatctcgatcctgagaaaaatgacagtgagcca
ggcagccagaggataaaacctgttttcattgaagatgctaattttggacgacaaatatct
tatcagcacgcagcagtccatattcctactgacatctatgagggctcaacaattgtgtta
aatgaactcaactggacaagtgccttagatgaagttttcaaaaagaatcgcgaggaagac
ccttcattattgtggcaggtttttggcagtgccactggcctagctcgatattatccagct
tcaccatgggttgataatagtagaactccaaataagattgacctttatgatgtacgcaga
agaccatggtacatccaaggagctgcatctcctaaagacatgcttattctggtggatgtg
agtggaagtgttagtggattgacacttaaactgatccgaacatctgtctccgaaatgtta
gaaaccctctcagatgatgatttcgtgaatgtagcttcatttaacagcaatgctcaggat
gtaagctgttttcagcaccttgtccaagcaaatgtaagaaataaaaaagtgttgaaagac
gcggtgaataatatcacagccaaaggaattacagattataagaagggctttagttttgct
tttgaacagctgcttaattataatgtttccagagcaaactgcaataagattattatgcta
ttcacggatggaggagaagagagagcccaggagatatttaacaaatacaataaagataaa
aaagtacgtgtattcacgttttcagttggtcaacacaattatgacagaggacctattcag
tggatggcctgtgaaaacaaaggttattattatgaaattccttccattggtgcaataaga
atcaatactcaggaatatttggatgttttgggaagaccaatggttttagcaggagacaaa
gctaagcaagtccaatggacaaatgtgtacctggatgcattggaactgggacttgtcatt
actggaactcttccggtcttcaacataaccggccaatttgaaaataagacaaacttaaag
aaccagctgattcttggtgtgatgggagtagatgtgtctttggaagatattaaaagactg
acaccacgttttacactgtgccccaatgggtattactttgcaatcgatcctaatggttat
gttttattacatccaaatcttcagccaaagcctattggtgtaggtataccaacaattaat
ttaagaaaaaggagacccaatatccagaaccccaaatctcaggagccagtaacattggat
ttccttgatgcagagttagagaatgatattaaagtggagattcgaaataagatgattgat
ggggaaagtggagaaaaaacattcagaactctggttaaatctcaagatgagagatatatt
gacaaaggaaacaggacatacacatggacacctgtcaatggcacagattacagtttggcc
ttggtattaccaacctacagtttttactatataaaagccaaactagaagagacaataact
caggccagatattcggaaaccctgaagccagataattttgaagaatctggctatacattc
atagcaccaagagattactgcaatgacctgaaaatatcggataataacactgaatttctt
ttaaatttcaacgagtttattgatagaaaaactccaaacaacccatcatgtaacgcggat
ttgattaatagagtcttgcttgatgcaggctttacaaatgaacttgtccaaaattactgg
agtaagcagaaaaatatcaagggagtgaaagcacgatttgttgtgactgatggtgggatt
accagagtttatcccaaagaggctggagaaaattggcaagaaaacccagagacatatgag
gacagcttctataaaaggagcctagataatgataactatgttttcactgctccctacttt
aacaaaagtggacctggtgcctatgaatcgggcattatggtaagcaaagctgtagaaata
tatattcaagggaaacttcttaaacctgcagttgttggaattaaaattgatgtaaattcc
tggatagagaatttcaccaaaacctcaatcagagatccgtgtgctggtccagtttgtgac
tgcaaaagaaacagtgacgtaatggattgtgtgattctggatgatggtgggtttcttctg
atggcaaatcatgatgattatactaatcagattggaagattttttggagagattgatccc
agcttgatgagacacctggttaatatatcagtttatgcttttaacaaatcttatgattat
cagtcagtatgtgagcccggtgctgcaccaaaacaaggagcaggacatcgctcagcatat
gtgccatcagtagcagacatattacaaattggctggtgggccactgctgctgcctggtct
attctacagcagtttctcttgagtttgacctttccacgactccttgaggcagttgagatg
gaggatgatgacttcacggcctccctgtccaagcagagctgcattactgaacaaacccag
tatttcttcgataacgacagtaaatcattcagtggtgtattagactgtggaaactgttcc
agaatctttcatggagaaaagcttatgaacaccaacttaatattcataatggttgagagc
aaagggacatgtccatgtgacacacgactgctcatacaagcggagcagacttctgacggt
ccaaatccttgtgacatggttaagcaacccagataccgaaaagggcctgatgtctgcttt
gataacaatgtcttggaggattatactgactgtggtggtgtttctggattaaatccctcc
ctgtggtatatcattggaatccagtttctactactttggctggtatctggcagcacacac
cgcctgttatga
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