KEGG   DISEASE: Diabetic neuropathy
Entry
H01459                      Disease                                
Name
Diabetic neuropathy
  Supergrp
Microvascular complications of diabetes [DS:H02559]
Description
Diabetic neuropathies (DNs) are nerve-damaging disorders caused by diabetes. Diabetic neuropathy broadly comprises generalized symmetric polyneuropathies (acute sensory, chronic sensorimotor, autonomic) and asymmetric (focal and multifocal) neuropathies (cranial, truncal, focal-limb, proximal-motor, coexisting chronic inflammatory demyelinating), which affect all organs and systems. Of all types, diabetic sensorimotor polyneuropathy (DSPN), also called distal symmetric neuropathy, is the most typical form. Typical symptoms vary from person to person, but may include numbness, tingling, pain, or weakness that typically starts in the feet and progresses up the legs. This pattern of neuropathy shows a progressive distal axonopathy. It has been reported that vascular endothelial growth factor A is associated with DNs development and progression.
Category
Endocrine and metabolic disease; Nervous system disease
Brite
Human diseases [BR:br08402]
 Nervous system diseases
  Other nervous and sensory system diseases
   H01459  Diabetic neuropathy
Human diseases in ICD-11 classification [BR:br08403]
 08 Diseases of the nervous system
  Disorders of nerve root, plexus or peripheral nerves
   Polyneuropathy
    8C03  Other secondary polyneuropathy
     H01459  Diabetic neuropathy
Related
pathway
hsa04933  AGE-RAGE signaling pathway in diabetic complications
Gene
VEGFA (polymorphism) [HSA:7422] [KO:K05448]
Drug
Becaplermin [DR:D03065]
Tapentadol hydrochloride [DR:D10199] (DPN)
Pregabalin [DR:D02716]
Duloxetine hydrochloride [DR:D01179]
Comment
Pregabalin [DR:D02716] (US and EU approved)
Other DBs
ICD-11: 8C03.0
ICD-10: E14.4
MeSH: D003929
OMIM: 603933
Reference
  Authors
Vinik A, Ullal J, Parson HK, Casellini CM
  Title
Diabetic neuropathies: clinical manifestations and current treatment options.
  Journal
Nat Clin Pract Endocrinol Metab 2:269-81 (2006)
DOI:10.1038/ncpendmet0142
Reference
  Authors
Gupta A, Gupta Y
  Title
Diabetic neuropathy: Part 1.
  Journal
J Pak Med Assoc 64:714-8 (2014)
Reference
  Authors
Bansal V, Kalita J, Misra UK
  Title
Diabetic neuropathy.
  Journal
Postgrad Med J 82:95-100 (2006)
DOI:10.1136/pgmj.2005.036137
Reference
  Authors
Witzel II, Jelinek HF, Khalaf K, Lee S, Khandoker AH, Alsafar H
  Title
Identifying Common Genetic Risk Factors of Diabetic Neuropathies.
  Journal
Front Endocrinol (Lausanne) 6:88 (2015)
DOI:10.3389/fendo.2015.00088
LinkDB

» Japanese version

DBGET integrated database retrieval system