KEGG   DRUG: Tepotinib hydrochloride
Entry
D11073                      Drug                                   

Name
Tepotinib hydrochloride (USAN);
Tepotinib hydrochloride hydrate (JAN);
Tepmetko (TN)
Formula
C29H28N6O2. HCl. H2O
Exact mass
546.2146
Mol weight
547.0478
Structure
Remark
Therapeutic category: 4291
Chemical structure group: DG03087
Product (DG03087): D11073<JP>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
MET* [HSA_VAR:4233v4] [HSA:4233] [KO:K05099]
  Network
N10024  Tyrosine kinase inhibitor to MET exon 14 skipping
  Pathway
hsa04014  Ras signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
hsa05223  Non-small cell lung cancer
Interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11073  Tepotinib hydrochloride (USAN); Tepotinib hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   MET family
    MET* [HSA_VAR:4233v4]
     D11073  Tepotinib hydrochloride (USAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11073
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11073
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11073
Other DBs
PubChem: 375581020
LinkDB
KCF data

ATOM        39
            1   N1y N    28.7700  -12.1800
            2   C1x C    28.7700  -13.5800
            3   C1x C    27.5800  -14.2800
            4   C1y C    26.3200  -13.5800
            5   C1x C    26.3200  -12.1800
            6   C1x C    27.5800  -11.4800
            7   C1a C    29.9600  -11.4800
            8   C1b C    25.1300  -14.2800
            9   O2a O    23.9400  -13.5800
            10  C8y C    22.7500  -14.2800
            11  C8x C    22.7500  -15.6800
            12  N5x N    21.4900  -16.3800
            13  C8y C    20.3000  -15.6800
            14  N5x N    20.3000  -14.2800
            15  C8x C    21.4900  -13.5800
            16  C8y C    19.1100  -16.3800
            17  C8x C    19.1100  -17.7800
            18  C8x C    17.8500  -18.4800
            19  C8x C    16.6600  -17.7800
            20  C8y C    16.6600  -16.3800
            21  C8x C    17.8500  -15.6800
            22  C1b C    15.4700  -15.6800
            23  N4y N    14.2800  -16.3800
            24  C8y C    14.2800  -17.7800
            25  C8x C    13.0200  -18.4800
            26  C8x C    11.8300  -17.7800
            27  C8y C    11.8300  -16.3800
            28  N5x N    13.0200  -15.6800
            29  O5x O    15.4700  -18.4800
            30  C8y C    10.6400  -15.6800
            31  C8x C     9.4500  -16.3800
            32  C8y C     8.1900  -15.6800
            33  C8x C     8.1900  -14.2800
            34  C8x C     9.3800  -13.5800
            35  C8x C    10.6400  -14.2800
            36  C3b C     7.0000  -16.3800
            37  N3a N     5.7400  -17.0800
            38  X   Cl   23.7300  -18.9700
            39  O0  O    27.2300  -18.9700
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17   13  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1
            32   24  29 2
            33   27  30 1
            34   30  31 2
            35   31  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   30  35 1
            40   32  36 1
            41   36  37 3

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