KEGG   DRUG: メトプロロール酒石酸塩
エントリ  
D00601                      Drug                                   

一般名   
メトプロロール酒石酸塩 (JP17);
Metoprolol tartrate (JP17/USP)
商品名   
  後発品
米国の商品 
  後発品
METOPROLOL TARTRATE (Alembic Pharmaceuticals), METOPROLOL TARTRATE (Alembic Pharmaceuticals Limited), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (A-S Medication Solutions), METOPROLOL TARTRATE (ACETRIS HEALTH), METOPROLOL TARTRATE (Actavis Pharma), METOPROLOL TARTRATE (Advagen Pharma Limited), METOPROLOL TARTRATE (Almaject), METOPROLOL TARTRATE (Alvogen), METOPROLOL TARTRATE (American Health Packaging), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Aphena Pharma Solutions - Tennessee), METOPROLOL TARTRATE (Apotheca), METOPROLOL TARTRATE (Asclemed USA), METOPROLOL TARTRATE (Athenex Pharmaceutical Division), METOPROLOL TARTRATE (Aurobindo Pharma Limited), METOPROLOL (Baxter Healthcare Corporation), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Bryant Ranch Prepack), METOPROLOL TARTRATE (Cambridge Therapeutics Technologies), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL TARTRATE (Cardinal Health), METOPROLOL (Cardinal Health), METOPROLOL TARTRATE (Clinical Solutions Wholesale), METOPROLOL TARTRATE (Clinical Solutions Wholesale), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (Contract Pharmacy Services-PA), METOPROLOL TARTRATE (DIRECT RX), METOPROLOL TARTRATE (DOH CENTRAL PHARMACY), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Denton Pharma), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Direct_Rx), METOPROLOL TARTRATE (Fosun Pharma USA), METOPROLOL (Fresenius Kabi USA), METOPROLOL TARTRATE (Gland Pharma Limited), METOPROLOL TARTRATE (HF Acquisition Co LLC), METOPROLOL TARTRATE (HF Acquisition Co LLC), METOPROLOL TARTRATE (Hospira), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Lake Erie Medical DBA Quality Care Products LLC), METOPROLOL TARTRATE (Legacy Pharmaceutical Packaging), METOPROLOL TARTRATE (Major Pharmaceuticals), METOPROLOL TARTRATE (Medical Purchasin Solutions), METOPROLOL (Medical Purchasing Solutions), METOPROLOL TARTRATE (Mylan Institutional), METOPROLOL TARTRATE (Mylan Pharmaceuticals), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (NCS HealthCare of KY), METOPROLOL TARTRATE (Northwind Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (NuCare Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (PD-Rx Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Preferred Pharmaceuticals), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (Proficient Rx LP), METOPROLOL TARTRATE (QPharma), METOPROLOL TARTRATE (QPharma), METOPROLOL TARTRATE (Quality Care Products), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (REMEDYREPACK), METOPROLOL TARTRATE (RedPharm Drug), METOPROLOL TARTRATE (RedPharm Drug), METOPROLOL TARTRATE (RedPharm Drug), METOPROLOL TARTRATE (Rising Health), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (St. Mary's Medical Park Pharmacy), METOPROLOL TARTRATE (Sun Pharmaceutical Industries), METOPROLOL TARTRATE (TruPharma LLC), METOPROLOL TARTRATE (Unit Dose Services), METOPROLOL TARTRATE (Youngtech Pharmaceuticals), METOPROLOL TARTRATE (Civica), METOPROLOL TARTRATE (West-Ward Pharmaceuticals Corp)
組成式   
(C15H25NO3)2. C4H6O6
質量    
684.3833
分子量   
684.8146
構造式   
Simcomp   
クラス   
循環器系用薬
 DG01653  抗不整脈薬
  DG01806  クラスII抗不整脈薬
 DG01466  アドレナリン受容体拮抗薬
  DG01464  β-アドレナリン受容体拮抗薬
   DG01461  β1-アドレナリン受容体拮抗薬
代謝酵素基質薬
 DG01644  CYP2D6基質薬
コード   
薬効分類: 2123 2149
ATCコード: C07AB02
化学構造グループ: DG00313
商品 (DG00313): D00601<JP/US> D00635<US>
商品 (mixture): D10273<US>
効能    
抗不整脈薬, 血圧降下薬, 血管拡張薬, β1遮断薬
  疾患
本態性高血圧症 [DS:H01633]
狭心症 [DS:H01632]
コメント  
プロプラノロール誘導体
β1選択性
ターゲット 
ADRB1 [HSA:153] [KO:K04141]
  パスウェイ
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04261  心筋細胞におけるアドレナリンシグナル伝達
代謝    
Enzyme: CYP2D6 [HSA:1565]
相互作用  

構造マップ 
map07037  抗不整脈薬
map07048  抗片頭痛薬
map07214  β-アドレナリン受容体の作動薬と拮抗薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   212  不整脈用剤
    2123  β−遮断剤
     D00601  メトプロロール酒石酸塩 (JP17)
   214  血圧降下剤
    2149  その他の血圧降下剤
     D00601  メトプロロール酒石酸塩 (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C07 ベータ遮断薬
   C07A ベータ遮断薬
    C07AB ベータ遮断薬、選択型
     C07AB02 メトプロロール
      D00601  メトプロロール酒石酸塩 (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  ベータアドレナリン遮断薬
   ベータ1選択的
    メトプロロール
     D00601  メトプロロール酒石酸塩 (JP17)
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  ロドプシンファミリー
   アドレナリン
    ADRB1
     D00601  メトプロロール酒石酸塩 (JP17) <JP/US>
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00601  メトプロロール酒石酸塩
  D00601  メトプロロール酒石酸塩錠
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D00601
ゲノムバイオマーカー [jp08341.html]
 医薬品応答に影響を与える多型と変異
  D00601
リンク   
CAS: 56392-17-7
PubChem: 7847667
ChEBI: 6906
ChEMBL: CHEMBL3186768
DrugBank: DB00264
LigandBox: D00601
日化辞: J523.393C
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