KEGG   DISEASE: Optic neuritis
Entry
H01717                      Disease                                

Name
Optic neuritis
Description
Optic neuritis is a demyelinating inflammatory disease of the optic nerve that presents with an abrupt loss of vision. The majority of patients are between the ages of 20 and 50 years, with a mean age ranging from 30 to 35 years. It occurs more commonly in women than in men. The onset is usually with pain on eye movement in one eye and subacute visual loss. One-third of patients have a mildly edematous optic disc. The visual disturbance resolves in 95% of cases. Many cases of optic neuritis are associated with multiple sclerosis or neuromyelitis optica or can occur in isolation. Occasionally, optic neuritis can result from infectious processes involving the paranasal sinuses or occur in the course of a systemic viral infection. High-dosed intravenous methylprednisolone therapy speeds recovery but does not improve the final outcome. For patients judged to be at high risk of developing multiple sclerosis, immune prophylaxis with beta-interferon or glatiramer acetate is recommended.
Category
Nervous system disease
Brite
Human diseases [BR:br08402]
 Nervous system diseases
  Eye disease
   H01717  Optic neuritis
Human diseases in ICD-11 classification [BR:br08403]
 09 Diseases of the visual system
  Disorders of the visual pathways or centres
   9C40  Disorder of the optic nerve
    H01717  Optic neuritis
Drug
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Prednisolone [DR:D00472]
Methylprednisolone [DR:D00407]
Corticotropin [DR:D00146]
Cortisone acetate [DR:D00973]
Comment
See also H01490 Multiple sclerosis and H01491 Neuromyelitis optica.
Other DBs
ICD-11: 9C40.1
ICD-10: H46
MeSH: D009902
Reference
  Authors
Pedro-Egbe CN, Fiebai B, Ejimadu CS
  Title
Visual outcome following optic neuritis: a 5-year review.
  Journal
Niger J Clin Pract 15:311-4 (2012)
DOI:10.4103/1119-3077.100628
Reference
  Authors
Gal RL, Vedula SS, Beck R
  Title
Corticosteroids for treating optic neuritis.
  Journal
Cochrane Database Syst Rev CD001430 (2015)
DOI:10.1002/14651858.CD001430.pub4
Reference
PMID:26396053 (drug)
  Authors
Wilhelm H, Schabet M
  Title
The Diagnosis and Treatment of Optic Neuritis.
  Journal
Dtsch Arztebl Int 112:616-25; quiz 626 (2015)
DOI:10.3238/arztebl.2015.0616
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