KEGG   DRUG: HydrocortisoneHelp
Entry
D00088                      Drug                                   

Name
Hydrocortisone (JP17/USP/INN);
HC;
Acticort (TN);
Anusol HC (TN);
Colocort (TN);
Cortef (TN);
Hytone (TN);
Plenadren (TN)
Product
  Generic
HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (Aidarex Pharmaceuticals LLC), HYDROCORTISONE (Aidarex Pharmaceuticals LLC), HYDROCORTISONE (American Health Packaging), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (CMP Pharma), HYDROCORTISONE (Carilion Materials Management), HYDROCORTISONE (Carilion Materials Management), HYDROCORTISONE (Central Texas Community Health Centers), HYDROCORTISONE (Crown Laboratories), ALACORT (Crown Laboratories), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (E. FOUGERA & CO. A division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E.FOUGERA & COMPANY A division of Fougera Pharmaceuticals), HYDROCORTISONE (Greenstone LLC), HYDROCORTISONE (Impax Generics), HOME PAPKIT (International Brand Management), HYDROCORTISONE (KAISER FOUNDATION HOSPITALS), HYDROCORTISONE (KAISER FOUNDATION HOSPITALS), HYDROCORTISONE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROCORTISONE (Lake Erie Medical DBA Quality Care Products LLC), HYDROCORTISONE (Lake Erie Medical DBA Quality Care Products LLC), PROCTO-MED HC (Leading Pharma), HYDROCORTISONE (Lineage Therapeutics), HYDROCORTISONE (Lyne Laboratories), HYDROCORTISONE (Major Pharmaceuticals), TEXACORT (Mission Pharmacal Company), PROCTO-MED HC (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), COLOCORT (Paddock Laboratories), HYDROCORTISONE (Par Pharmaceutical), HYDROCORTISONE (Par Pharmaceutical), HYDROCORTISONE (Par Pharmaceutical), HYDROCORTISONE (Perrigo New York), HYDROCORTISONE (Perrigo New York), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), PROCTOZONE (Preferred Pharmaceuticals), PROCTOSOL-HC (Preferred Pharmaceuticals), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), PROCTOSOL-HC (Ranbaxy Laboratories), HYDROCORTISONE (Rebel Distributors Corp), HYDROCORTISONE (Rebel Distributors Corp), HYDROCORTISONE (Rebel Distributors Corp), PROCTO-PAK (Rising Pharmaceuticals), PROCTOZONE (Rising Pharmaceuticals), ANUSOL (Salix Pharmaceuticals), PROCTOCORT (Salix Pharmaceuticals), HYDROCORTISONE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE (Teligent Pharma), HYDROCORTISONE (Teligent Pharma), HYDROCORTISONE (Unit Dose Services), HYDROCORTISONE (Unit Dose Services), HYDROCORTISONE (Vensun Pharmaceuticals), HYDROCORTISONE (West-Ward Pharmaceuticals Corp), HYDROCORTISONE 1% IN ABSORBASE (Solubiomix), PROCTOZONE-HC (Preferred Pharmaceuticals), PROCTOZONE-HC (Rising Pharmaceuticals)
Formula
C21H30O5
Exact mass
362.2093
Mol weight
362.4599
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C00735
Therapeutic category: 2452
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<JP/US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Product (mixture): D04699<JP> D08828<JP> D08827<JP> D04801<JP> D04776<JP>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Ulcerative colitis [DS:H01466]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Acute gouty arthritis [DS:H01532]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Mycosis fungoides [DS:H01463]
Psoriasis [DS:H01656]
Seborrheic dermatitis [DS:H01652]
Seasonal or perennial allergic rhinitis [DS:H01360]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Herpes zoster ophthalmicus [DS:H00366]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Multiple sclerosis [DS:H01490]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00088  Hydrocortisone (JP17/USP/INN)
  Hydrocortisone
   D00088  Hydrocortisone (JP17/USP/INN)
  Hydrocortisone
   D00088  Hydrocortisone (JP17/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00088  Hydrocortisone (JP17/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00088  Hydrocortisone (JP17/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00088  Hydrocortisone (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00088  Hydrocortisone
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D00088
Topical steroids potency [br08317.html]
 Classification in the USA
  D00088
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00088
Rx-to-OTC switch list in the USA [br08315.html]
 D00088
BRITE hierarchy
Other DBs
CAS: 50-23-7
PubChem: 7847156
ChEBI: 17650
ChEMBL: CHEMBL1092578 CHEMBL196519 CHEMBL389621
DrugBank: DB00741
PDB-CCD: HCY[PDBj]
LigandBox: D00088
NIKKAJI: J1.908I
LinkDB All DBs
KCF data Show

ATOM        26
            1   C1y C    25.3915  -16.8055
            2   C1y C    24.2081  -17.4875
            3   C1z C    25.3915  -15.4414
            4   C1x C    27.7583  -16.8055
            5   C1y C    23.0247  -16.8055
            6   C1x C    24.1965  -18.8575
            7   C1z C    26.5809  -14.7535
            8   C1x C    24.2081  -14.7535
            9   C1a C    25.3858  -14.0713
            10  C1x C    27.7583  -15.4414
            11  C1z C    21.8356  -17.4875
            12  C1y C    23.0247  -15.4414
            13  C1x C    23.0247  -19.5395
            14  C5a C    26.5866  -13.3893
            15  C2y C    21.8356  -18.8575
            16  C1x C    20.6579  -16.8055
            17  C1a C    21.8239  -16.1233
            18  O1a O    21.8356  -14.7535
            19  C1b C    27.7643  -12.7072
            20  O5a O    25.3975  -12.7072
            21  C2x C    20.6579  -19.5395
            22  C1x C    19.4687  -17.4875
            23  O1a O    28.9534  -13.3951
            24  C5x C    19.4687  -18.8575
            25  O5x O    18.2853  -19.5395
            26  O1a O    27.9332  -14.3911
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down

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