KEGG   DISEASE: 本態性振戦
エントリ  
H01577                                                             
名称    
本態性振戦
概要    
Essential tremor (ET) is a neurological disorder that is considered to be one of the most common adult-onset movement disorders. ET is typically characterized by rhythmic, involuntary shaking of one or more parts of the body, and occurs exclusively during voluntary movements (action tremor) or in positions against gravity (postural tremor). The phenotypic severity of ET is variable, as evidenced by the existence of both highly disabling and milder forms of the disease. There are three subtypes of ET, namely hereditary, sporadic, and senile, and most studies indicate that ET is a hereditary disorder in more than half of affected individuals (and presumably has autosomal-dominant inheritance). The diagnostic approach includes obtaining a history, physical examination, and laboratory tests. At present, there are no validated serologic, radiologic, or pathological markers.
カテゴリ  
神経系疾患
階層分類  
ICD-11 による疾患分類 [BR:jp08403]
 08 神経系の疾患
  運動障害
   8A04  振戦に関連した障害
    H01577  本態性振戦
パスウェイに基づく疾患分類 [BR:jp08402]
 細胞プロセス
  nt06544  神経刺激性リガンドのシグナリング
   H01577  本態性振戦
パスウェイ 
hsa04728  Dopaminergic synapse
hsa04082  Neuroactive ligand signaling
hsa04080  Neuroactive ligand-receptor interaction
hsa03015  mRNA surveillance pathway
hsa03013  Nucleocytoplasmic transport
ネットワーク
nt06544 Neuroactive ligand signaling
病因遺伝子 
(ETM1) DRD3 [HSA:1814] [KO:K04146]
(ETM4) FUS [HSA:2521] [KO:K13098]
(ETM5) TENM4 [HSA:26011] [KO:K24473]
(ETM6) NOTCH2NLC [HSA:100996717] [KO:K24466]
治療薬   
アロチノロール塩酸塩 [DR:D01830]
リンク   
ICD-11: 8A04.1
MeSH: D020329
OMIM: 190300 614782 616736 618866
文献    
  著者
Louis ED
  タイトル
Clinical practice. Essential tremor.
  雑誌
N Engl J Med 345:887-91 (2001)
DOI:10.1056/NEJMcp010928
文献    
  著者
Deng H, Le W, Jankovic J
  タイトル
Genetics of essential tremor.
  雑誌
Brain 130:1456-64 (2007)
DOI:10.1093/brain/awm018
文献    
PMID:16650084 (ETM1)
  著者
Lucotte G, Lagarde JP, Funalot B, Sokoloff P
  タイトル
Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families.
  雑誌
Clin Genet 69:437-40 (2006)
DOI:10.1111/j.1399-0004.2006.00600.x
文献    
PMID:22863194 (ETM4)
  著者
Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Riviere JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupre N, Bernard G, Chouinard S, Dion PA, Rouleau GA
  タイトル
Exome sequencing identifies FUS mutations as a cause of essential tremor.
  雑誌
Am J Hum Genet 91:313-9 (2012)
DOI:10.1016/j.ajhg.2012.07.002
文献    
PMID:26188006 (ETM5)
  著者
Hor H, Francescatto L, Bartesaghi L, Ortega-Cubero S, Kousi M, Lorenzo-Betancor O, Jimenez-Jimenez FJ, Gironell A, Clarimon J, Drechsel O, Agundez JA, Kenzelmann Broz D, Chiquet-Ehrismann R, Lleo A, Coria F, Garcia-Martin E, Alonso-Navarro H, Marti MJ, Kulisevsky J, Hor CN, Ossowski S, Chrast R, Katsanis N, Pastor P, Estivill X
  タイトル
Missense mutations in TENM4, a regulator of axon guidance and central myelination, cause essential tremor.
  雑誌
Hum Mol Genet 24:5677-86 (2015)
DOI:10.1093/hmg/ddv281
文献    
PMID:32516806 (ETM6)
  著者
Yau WY, O'Connor E, Chen Z, Vandrovcova J, Wood NW, Houlden H
  タイトル
GGC repeat expansion in NOTCH2NLC is rare in European patients with essential tremor.
  雑誌
Brain 143:e57 (2020)
DOI:10.1093/brain/awaa144
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