KEGG   ENZYME: 1.1.1.39Help
Entry
EC 1.1.1.39                 Enzyme                                 

Name
malate dehydrogenase (decarboxylating);
'malic' enzyme;
pyruvic-malic carboxylase;
NAD-specific malic enzyme;
NAD-malic enzyme
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG)
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Does not decarboxylate added oxaloacetate.
History
EC 1.1.1.39 created 1961
Pathway
ec00620  Pyruvate metabolism
ec00710  Carbon fixation in photosynthetic organisms
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00028  malate dehydrogenase (decarboxylating)
Genes
ATH: AT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY: ARALYDRAFT_480310 ARALYDRAFT_912183
CRB: 17882677 17890615
CSAT: 104705320 104712096 104731652 104737720 104747328 104748683 104766630 104793732
EUS: EUTSA_v10022600mg EUTSA_v10028520mg
BRP: 103836911 103837635 103858863
BNA: 106365524 106366363 106388718 106410651 106434956 106438600
BOE: 106318356 106318857 106328013
THJ: 104801455 104817017 104821820
CPAP: 110814719 110819439
LJA: Lj3g3v0618140.1(Lj3g3v0618140.1) Lj3g3v0618140.2(Lj3g3v0618140.2)
SOT: 102581802(NAD-ME) 102598070(NAD-ME)
DOSA: Os07t0496200-01(Os07g0496200) Os10t0503500-01(Os10g0503500)
ATS: 109740058(LOC109740058) 109765298(LOC109765298)
ZMA: 100191942(pco115183b) 100501486
PPP: 112288778
CRE: CHLREDRAFT_196833(MME1)
MIS: MICPUN_55180(NAD-ME)
MPP: MICPUCDRAFT_43783(NADP-ME_2)
 » show all
Taxonomy
Reference
1  [PMID:13416294]
  Authors
SAZ HJ, HUBBARD JA.
  Title
The oxidative decarboxylation of malate by Ascaris lumbricoides.
  Journal
J Biol Chem 225:921-33 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.39
IUBMB Enzyme Nomenclature: 1.1.1.39
ExPASy - ENZYME nomenclature database: 1.1.1.39
BRENDA, the Enzyme Database: 1.1.1.39
CAS: 9028-46-0
LinkDB All DBs

DBGET integrated database retrieval system