| Entry |
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| Name |
cysteate synthase;
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
sulfite:O-phospho-L-serine sulfonotransferase (phosphate-hydrolysing, L-cysteate-forming)
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| Reaction(IUBMB) |
O-phospho-L-serine + sulfite = L-cysteate + phosphate [RN: R09530]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).
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| History |
EC 2.5.1.76 created 2009
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Graham DE, Taylor SM, Wolf RZ, Namboori SC |
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| Title |
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.76 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.76 |
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| LinkDB |
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