KEGG   ENZYME: 2.5.1.65
Entry
EC 2.5.1.65                 Enzyme                                 
Name
O-phosphoserine sulfhydrylase;
O-phosphoserine(thiol)-lyase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate [RN:R07274]
Reaction(KEGG)
R07274;
(other) R00897
Substrate
O-phospho-L-serine [CPD:C01005];
hydrogen sulfide [CPD:C00283]
Product
L-cysteine [CPD:C00097];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.
History
EC 2.5.1.65 created 2004
Pathway
ec00270  Cysteine and methionine metabolism
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K10150  cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Genes
APE: APE_1586(cysK)
ACJ: ACAM_0997(cysK)
DFD: Desfe_0630
DMU: Desmu_0644
TAG: Tagg_1314
IAG: Igag_1783
THG: TCELL_0171
HBU: Hbut_1585
PFM: Pyrfu_1108
PDL: Pyrde_0768
PABI: PABY_05110
PIS: Pisl_1761
TPE: Tpen_1605
THB: N186_00700
TCB: TCARB_1222
ASC: ASAC_0793
ACIA: SE86_05800
CLG: Calag_0796
CCAI: NAS2_0810
 » show all
Reference
1  [PMID:12965218]
  Authors
Mino K, Ishikawa K.
  Title
A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
FEBS Lett 551:133-8 (2003)
DOI:10.1016/S0014-5793(03)00913-X
Reference
2  [PMID:12644499]
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
  Sequence
[ape:APE_1586]
Reference
3  [PMID:12554945]
  Authors
Mino K, Oda Y, Ataka M, Ishikawa K.
  Title
Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
Acta Crystallogr D Biol Crystallogr 59:338-40 (2003)
DOI:10.1107/S0907444902017900
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.65
IUBMB Enzyme Nomenclature: 2.5.1.65
ExPASy - ENZYME nomenclature database: 2.5.1.65
BRENDA, the Enzyme Database: 2.5.1.65
CAS: 1071505-11-7
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