| Entry |
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| Name |
peptidyl-dipeptidase A;
dipeptidyl carboxypeptidase I;
peptidase P;
dipeptide hydrolase (ambiguous);
peptidyl dipeptidase;
angiotensin converting enzyme;
kininase II;
angiotensin I-converting enzyme;
carboxycathepsin;
dipeptidyl carboxypeptidase;
peptidyl dipeptidase I;
peptidyl-dipeptide hydrolase;
peptidyldipeptide hydrolase;
endothelial cell peptidyl dipeptidase;
ACE;
peptidyl dipeptidase-4;
PDH;
peptidyl dipeptide hydrolase;
DCP
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Peptidyl-dipeptidases
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| Reaction(IUBMB) |
Release of a C-terminal dipeptide, oligopeptide!Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II
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| Comment |
A Cl--dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2
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| History |
EC 3.4.15.1 created 1972, modified 1981, modified 1989, modified 1996, modified 2011
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P. |
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| Title |
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Ehlers MR, Fox EA, Strydom DJ, Riordan JF. |
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| Title |
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wei L, Clauser E, Alhenc-Gelas F, Corvol P. |
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| Title |
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. |
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| Journal |
J Biol Chem 267:13398-405 (1992) |
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| Reference |
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| Authors |
Corvol P, Williams TA, Soubrier F. |
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| Title |
Peptidyl dipeptidase A: angiotensin I-converting enzyme. |
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| Journal |
Methods Enzymol 248:283-305 (1995) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.15.1 |
| ExPASy - ENZYME nomenclature database: | 3.4.15.1 |
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| LinkDB |
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