KEGG   ENZYME: 4.1.1.111
Entry
EC 4.1.1.111                Enzyme                                 

Name
siroheme decarboxylase;
sirohaem decarboxylase;
nirDLHG (gene name);
ahbAB (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
siroheme carboxy-lyase
Reaction(IUBMB)
siroheme = 12,18-didecarboxysiroheme + 2 CO2 [RN:R12000]
Reaction(KEGG)
R12000
Substrate
siroheme [CPD:C00748]
Product
12,18-didecarboxysiroheme [CPD:C21835];
CO2 [CPD:C00011]
Comment
The enzyme from archaea is involved in an alternative heme biosynthesis pathway. The enzyme from denitrifying bacteria is involved in the heme d1 biosynthesis pathway.
History
EC 4.1.1.111 created 2018
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22225  siroheme decarboxylase
Genes
COV: EKO29_12265 EKO29_12270
LSD: EMK97_08065
MARA: D0851_08700 D0851_08705 D0851_08710
MARJ: MARI_00440 MARI_00450 MARI_00460
MMT: Metme_4007
MDN: JT25_014100
MDH: AYM39_03570
MKO: MKLM6_0753 MKLM6_0754 MKLM6_0755
METL: U737_19780 U737_19785 U737_19790
TIG: THII_2878
TNI: TVNIR_1644(nirD_[H])
HPSE: HPF_07380
OTR: OTERR_20900(nirH) OTERR_20910(nirG)
DAT: HRM2_22040(nirD)
DALK: DSCA_28010
SAT: SYN_02265
AOL: S58_68160
PAMN: pAMV3p0217(nirH) pAMV3p0218(nirG)
DSH: Dshi_3175(nirG)
CKL: CKL_0377
CKR: CKR_0327
MHG: MHY_22630
PFT: JBW_01636
KST: KSMBR1_2939(nirD_nirG) KSMBR1_2940(nirH_nirL)
CTHI: THC_1535
MAC: MA_0574(nirD) MA_0575(nirH)
MMA: MM_1727(nirD) MM_1728(nirH) MM_1738(nirD) MM_1739(nirH)
MHI: Mhar_0167
MBN: Mboo_0956
LOKI: Lokiarch_30580(lrpA_2)
 » show all
Reference
1  [PMID:21969545]
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
Reference
2  [PMID:24669201]
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G.
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Reference
3  [PMID:24865947]
  Authors
Palmer DJ, Schroeder S, Lawrence AD, Deery E, Lobo SA, Saraiva LM, McLean KJ, Munro AW, Ferguson SJ, Pickersgill RW, Brown DG, Warren MJ
  Title
The structure, function and properties of sirohaem decarboxylase--an enzyme with  structural homology to a transcription factor family that is part of the alternative haem biosynthesis pathway.
  Journal
Mol Microbiol 93:247-61 (2014)
DOI:10.1111/mmi.12656
  Sequence
Reference
4  [PMID:25083922]
  Authors
Haufschildt K, Schmelz S, Kriegler TM, Neumann A, Streif J, Arai H, Heinz DW, Layer G
  Title
The crystal structure of siroheme decarboxylase in complex with iron-uroporphyrin III reveals two essential histidine residues.
  Journal
J Mol Biol 426:3272-3286 (2014)
DOI:10.1016/j.jmb.2014.07.021
  Sequence
[hth:HTH_0209]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.111
IUBMB Enzyme Nomenclature: 4.1.1.111
ExPASy - ENZYME nomenclature database: 4.1.1.111
BRENDA, the Enzyme Database: 4.1.1.111
LinkDB

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