KEGG   Homo sapiens (human): 1719
Entry
1719              CDS       T01001                                 

Gene name
DHFR, DHFRP1, DYR
Definition
(RefSeq) dihydrofolate reductase
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa01523  Antifolate resistance
Disease
H01197  Dihydrofolate reductase deficiency
Drug target
Edatrexate: D03942
Methotrexate (DG00681): D00142 D02115
Pemetrexed (DG00682): D03828 D06503 D07472 D10596 D11352
Piritrexim isethionate: D05500
Pralatrexate: D05589
Talotrexin ammonium: D05999
Trimetrexate (DG01013): D06238 D06239
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    1719 (DHFR)
   00670 One carbon pool by folate
    1719 (DHFR)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    1719 (DHFR)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     1719 (DHFR)
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-GeneID: 1719
NCBI-ProteinID: NP_000782
OMIM: 126060
HGNC: 2861
Ensembl: ENSG00000228716
Vega: OTTHUMG00000162529
Pharos: P00374(Tclin)
UniProt: P00374 B0YJ76
LinkDB
Structure
PDB: 

Position
5q14.1
AA seq 187 aa
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
NT seq 564 nt   +upstreamnt  +downstreamnt
atggttggttcgctaaactgcatcgtcgctgtgtcccagaacatgggcatcggcaagaac
ggggacctgccctggccaccgctcaggaatgaattcagatatttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaagaagacctggttctcc
attcctgagaagaatcgacctttaaagggtagaattaatttagttctcagcagagaactc
aaggaacctccacaaggagctcattttctttccagaagtctagatgatgccttaaaactt
actgaacaaccagaattagcaaataaagtagacatggtctggatagttggtggcagttct
gtttataaggaagccatgaatcacccaggccatcttaaactatttgtgacaaggatcatg
caagactttgaaagtgacacgttttttccagaaattgatttggagaaatataaacttctg
ccagaatacccaggtgttctctctgatgtccaggaggagaaaggcattaagtacaaattt
gaagtatatgagaagaatgattaa

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