Homo sapiens (human): 1719
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Entry
1719 CDS
T01001
Gene name
DHFR, DHFRP1, DYR
Definition
(RefSeq) dihydrofolate reductase
KO
K00287
dihydrofolate reductase [EC:
1.5.1.3
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00670
One carbon pool by folate
hsa00790
Folate biosynthesis
hsa01100
Metabolic pathways
hsa01240
Biosynthesis of cofactors
hsa01523
Antifolate resistance
Disease
H01197
Dihydrofolate reductase deficiency
Drug target
Edatrexate:
D03942
Methotrexate (
DG00681
):
D00142
<JP/US>
D02115
<US>
Pemetrexed (
DG00682
):
D03828
D06503
<JP/US>
D07472
D10596
D11352
Piritrexim isethionate:
D05500
Pralatrexate:
D05589
<JP/US>
Talotrexin ammonium:
D05999
Trimetrexate (
DG01013
):
D06238
D06239
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
1719 (DHFR)
00670 One carbon pool by folate
1719 (DHFR)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
1719 (DHFR)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
1719 (DHFR)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DHFR_1
Motif
Other DBs
NCBI-GeneID:
1719
NCBI-ProteinID:
NP_000782
OMIM:
126060
HGNC:
2861
Ensembl:
ENSG00000228716
Vega:
OTTHUMG00000162529
Pharos:
P00374
(Tclin)
UniProt:
P00374
B0YJ76
LinkDB
All DBs
Structure
PDB:
1KMV
1KMS
4M6J
5HSR
3FS6
3GHW
2W3B
3GHV
3GHC
4G95
3NXO
3NXR
3NXX
3NTZ
3NU0
4M6K
2C2S
4KEB
3F8Y
5HVE
5HUI
5HSU
5HQY
5HQZ
2W3A
2C2T
3S3V
3GI2
6DAV
5HVB
5HT4
2W3M
4QHV
4QJC
5HPB
4M6L
3OAF
3NXT
3GYF
3EIG
4KFJ
4KAK
3S7A
3NZD
1S3V
1MVT
4KBN
6A7E
5HT5
3NXV
3NXY
3F91
1U72
1S3W
1MVS
3N0H
3L3R
1DRF
3F8Z
4DDR
6A7C
1PD8
1BOZ
1HFP
1HFQ
1HFR
1U71
1PD9
1PDB
1DLR
1DLS
1DHF
2DHF
6DE4
1S3U
1OHJ
1OHK
4KD7
1YHO
Thumbnails
Position
5q14.1
AA seq
187 aa
AA seq
DB search
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
NT seq
564 nt
NT seq
+upstream
nt +downstream
nt
atggttggttcgctaaactgcatcgtcgctgtgtcccagaacatgggcatcggcaagaac
ggggacctgccctggccaccgctcaggaatgaattcagatatttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaagaagacctggttctcc
attcctgagaagaatcgacctttaaagggtagaattaatttagttctcagcagagaactc
aaggaacctccacaaggagctcattttctttccagaagtctagatgatgccttaaaactt
actgaacaaccagaattagcaaataaagtagacatggtctggatagttggtggcagttct
gtttataaggaagccatgaatcacccaggccatcttaaactatttgtgacaaggatcatg
caagactttgaaagtgacacgttttttccagaaattgatttggagaaatataaacttctg
ccagaatacccaggtgttctctctgatgtccaggaggagaaaggcattaagtacaaattt
gaagtatatgagaagaatgattaa
DBGET
integrated database retrieval system