KEGG   Homo sapiens (human): 1719
Entry
1719              CDS       T01001                                 

Gene name
DHFR, DHFRP1, DYR
Definition
(RefSeq) dihydrofolate reductase
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa01523  Antifolate resistance
Disease
H01197  Dihydrofolate reductase deficiency
Drug target
Edatrexate: D03942
Methotrexate (DG00681): D00142<JP/US> D02115<US>
Pemetrexed (DG00682): D03828 D06503<JP/US> D07472 D10596 D11352
Piritrexim isethionate: D05500
Pralatrexate: D05589<JP/US>
Talotrexin ammonium: D05999
Trimetrexate (DG01013): D06238 D06239
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    1719 (DHFR)
   00670 One carbon pool by folate
    1719 (DHFR)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    1719 (DHFR)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     1719 (DHFR)
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-GeneID: 1719
NCBI-ProteinID: NP_000782
OMIM: 126060
HGNC: 2861
Ensembl: ENSG00000228716
Vega: OTTHUMG00000162529
Pharos: P00374(Tclin)
UniProt: P00374 B0YJ76
LinkDB
Structure
PDB: 

Position
5q14.1
AA seq 187 aa
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
NT seq 564 nt   +upstreamnt  +downstreamnt
atggttggttcgctaaactgcatcgtcgctgtgtcccagaacatgggcatcggcaagaac
ggggacctgccctggccaccgctcaggaatgaattcagatatttccagagaatgaccaca
acctcttcagtagaaggtaaacagaatctggtgattatgggtaagaagacctggttctcc
attcctgagaagaatcgacctttaaagggtagaattaatttagttctcagcagagaactc
aaggaacctccacaaggagctcattttctttccagaagtctagatgatgccttaaaactt
actgaacaaccagaattagcaaataaagtagacatggtctggatagttggtggcagttct
gtttataaggaagccatgaatcacccaggccatcttaaactatttgtgacaaggatcatg
caagactttgaaagtgacacgttttttccagaaattgatttggagaaatataaacttctg
ccagaatacccaggtgttctctctgatgtccaggaggagaaaggcattaagtacaaattt
gaagtatatgagaagaatgattaa

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