KEGG   Homo sapiens (human): 200895
Entry
200895            CDS       T01001                                 
Symbol
DHFR2, DHFRL1, DHFRP4
Name
(RefSeq) dihydrofolate reductase 2
  KO
K00287  dihydrofolate reductase [EC:1.5.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa00790  Folate biosynthesis
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa01523  Antifolate resistance
Network
nt06037  Histidine metabolism
  Element
N01725  Tetrahydrofolate biosynthesis
Drug target
Edatrexate: D03942
Methotrexate (DG00681): D00142<JP/US> D02115<US>
Pemetrexed (DG00682): D03828<US> D06503<JP/US> D07472<US> D10596<JP/US> D11352<US>
Piritrexim isethionate: D05500
Pralatrexate: D05589<JP/US>
Talotrexin ammonium: D05999
Trimetrexate (DG01013): D06238 D06239
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    200895 (DHFR2)
   00670 One carbon pool by folate
    200895 (DHFR2)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    200895 (DHFR2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     200895 (DHFR2)
SSDB
Motif
Pfam: DHFR_1
Other DBs
NCBI-GeneID: 200895
NCBI-ProteinID: NP_001182572
OMIM: 616588
HGNC: 27309
Ensembl: ENSG00000178700
UniProt: Q86XF0
LinkDB
Position
3:complement(94057922..94063320)
AA seq 187 aa
MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
EVCEKDD
NT seq 564 nt   +upstreamnt  +downstreamnt
atgtttcttttgctaaactgcatcgtcgctgtgtcccaaaacatgggcatcggcaagaac
ggggacctgcccaggccgccgctcaggaatgaattcaggtatttccagagaatgaccaca
acttcttcagtagagggtaaacagaatctggtgattatgggtaggaagacctggttctcc
attcctgagaagaatcgacctttaaaggatagaattaatttagttctcagcagagaactc
aaggaacctccacaaggagctcattttcttgccagaagtttggatgatgccttaaaactt
actgaacgaccagaattagcaaataaagtagacatgatttggatagttggtggcagttct
gtttataaggaagccatgaatcacctaggccatcttaaactatttgtgacaaggatcatg
caggactttgaaagtgacacgtttttttcagaaattgacttggagaaatataaacttctg
cctgaatacccaggtgttctctctgatgtccaggaggggaaacacatcaagtacaaattt
gaagtatgtgagaaggatgattaa

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