KEGG T01001: 2209

Homo sapiens (human): 2209

Entry

2209 CDS T01001

Gene name

FCGR1A, CD64, CD64A, FCRI, IGFR1

Definition

(RefSeq) Fc fragment of IgG receptor Ia

K06498

high affinity immunoglobulin gamma Fc receptor I

Organism

hsa Homo sapiens (human)

Pathway

hsa04145

Phagosome

hsa04380

Osteoclast differentiation

hsa04613

Neutrophil extracellular trap formation

hsa04640

Hematopoietic cell lineage

hsa04666

Fc gamma R-mediated phagocytosis

hsa05140

Leishmaniasis

hsa05150

Staphylococcus aureus infection

hsa05152

Tuberculosis

hsa05202

Transcriptional misregulation in cancer

hsa05221

Acute myeloid leukemia

hsa05322

Systemic lupus erythematosus

Network

nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06240  Transcription
nt06275  Acute myeloid leukemia

Element

N00112

AML1-ETO fusion to PU.1-mediated transcription

N01090

IGG-FCGR-RAC signaling pathway

N01091

Escherichia EspJ to IGG-FCGR-RAC signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    2209 (FCGR1A)
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    2209 (FCGR1A)
   04613 Neutrophil extracellular trap formation
    2209 (FCGR1A)
   04666 Fc gamma R-mediated phagocytosis
    2209 (FCGR1A)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    2209 (FCGR1A)
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    2209 (FCGR1A)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    2209 (FCGR1A)
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    2209 (FCGR1A)
   05152 Tuberculosis
    2209 (FCGR1A)
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    2209 (FCGR1A)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    2209 (FCGR1A)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    2209 (FCGR1A)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    2209 (FCGR1A)
Membrane trafficking [BR:hsa04131]
Endocytosis
  Phagocytosis
   Fc receptors
    2209 (FCGR1A)
CD molecules [BR:hsa04090]
Proteins
  2209 (FCGR1A)

SSDB

Motif

Pfam:

Ig_2 Ig_3 ig V-set I-set Ig_4 PIRT Adeno_E3_CR1 SID-1_RNA_chan

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P12314(Tchem)

UniProt:

P12314

LinkDB

Structure

PDB:

4ZNE 3RJD

Position

1q21.2

AA seq 374 aa
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG
TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL
ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG
ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN
TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG
IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ
LQEGVHRKEPQGAT

NT seq 1125 nt +upstreamnt +downstreamnt
atgtggttcttgacaactctgctcctttgggttccagttgatgggcaagtggacaccaca
aaggcagtgatcactttgcagcctccatgggtcagcgtgttccaagaggaaaccgtaacc
ttgcactgtgaggtgctccatctgcctgggagcagctctacacagtggtttctcaatggc
acagccactcagacctcgacccccagctacagaatcacctctgccagtgtcaatgacagt
ggtgaatacaggtgccagagaggtctctcagggcgaagtgaccccatacagctggaaatc
cacagaggctggctactactgcaggtctccagcagagtcttcacggaaggagaacctctg
gccttgaggtgtcatgcgtggaaggataagctggtgtacaatgtgctttactatcgaaat
ggcaaagcctttaagtttttccactggaattctaacctcaccattctgaaaaccaacata
agtcacaatggcacctaccattgctcaggcatgggaaagcatcgctacacatcagcagga
atatctgtcactgtgaaagagctatttccagctccagtgctgaatgcatctgtgacatcc
ccactcctggaggggaatctggtcaccctgagctgtgaaacaaagttgctcttgcagagg
cctggtttgcagctttacttctccttctacatgggcagcaagaccctgcgaggcaggaac
acatcctctgaataccaaatactaactgctagaagagaagactctgggttatactggtgc
gaggctgccacagaggatggaaatgtccttaagcgcagccctgagttggagcttcaagtg
cttggcctccagttaccaactcctgtctggtttcatgtccttttctatctggcagtggga
ataatgtttttagtgaacactgttctctgggtgacaatacgtaaagaactgaaaagaaag
aaaaagtgggatttagaaatctctttggattctggtcatgagaagaaggtaatttccagc
cttcaagaagacagacatttagaagaagagctgaaatgtcaggaacaaaaagaagaacag
ctgcaggaaggggtgcaccggaaggagccccagggggccacgtag

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