KEGG   NETWORK: N01091
Entry
N01091                      Network                                
Name
Escherichia EspJ to IGG-FCGR-RAC signaling pathway
Definition
EspJ -| SRC -> FCGR
  Expanded
K23648 -| 6714 -> (2209,2212,2214,2215)
Class
nt06180 Pathogenic Escherichia coli
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2209  FCGR1A; Fc fragment of IgG receptor Ia
2212  FCGR2A; Fc fragment of IgG receptor IIa
2214  FCGR3A; Fc fragment of IgG receptor IIIa
2215  FCGR3B; Fc fragment of IgG receptor IIIb
Perturbant
K23648 (EspJ)  espJ; T3SS secreted effector ADP-ribosyltransferase EspJ
Reference
PMID:25523213
  Authors
Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G
  Title
The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.
  Journal
Nat Commun 5:5887 (2014)
DOI:10.1038/ncomms6887
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