Homo sapiens (human): 2983
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Entry
2983 CDS
T01001
Symbol
GUCY1B1, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, GUCY1B3
Name
(RefSeq) guanylate cyclase 1 soluble subunit beta 1
KO
K12319
guanylate cyclase soluble subunit beta [EC:
4.6.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04022
cGMP-PKG signaling pathway
hsa04270
Vascular smooth muscle contraction
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04713
Circadian entrainment
hsa04730
Long-term depression
hsa04921
Oxytocin signaling pathway
hsa04924
Renin secretion
hsa04970
Salivary secretion
Drug target
Amyl nitrite:
D00517
<JP>
Avenciguat:
D13034
Cinaciguat:
D07577
Nicorandil:
D01810
<JP>
Olinciguat:
D11475
Praliciguat:
D11274
Riociguat:
D09572
<JP/US>
Vericiguat:
D11051
<JP/US>
Zagociguat:
D12516
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
2983 (GUCY1B1)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
2983 (GUCY1B1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
2983 (GUCY1B1)
09152 Endocrine system
04921 Oxytocin signaling pathway
2983 (GUCY1B1)
04924 Renin secretion
2983 (GUCY1B1)
09154 Digestive system
04970 Salivary secretion
2983 (GUCY1B1)
09156 Nervous system
04730 Long-term depression
2983 (GUCY1B1)
09159 Environmental adaptation
04713 Circadian entrainment
2983 (GUCY1B1)
Enzymes [BR:
hsa01000
]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.2 guanylate cyclase
2983 (GUCY1B1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Guanylate_cyc
HNOBA
HNOB
Motif
Other DBs
NCBI-GeneID:
2983
NCBI-ProteinID:
NP_000848
OMIM:
139397
HGNC:
4687
Ensembl:
ENSG00000061918
UniProt:
Q02153
Structure
PDB
PDBj
LinkDB
All DBs
Position
4:155759021..155807811
Genome browser
AA seq
619 aa
AA seq
DB search
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
NT seq
1860 nt
NT seq
+upstream
nt +downstream
nt
atgtacggatttgtgaatcacgccctggagttgctggtgatccgcaattacggccccgag
gtgtgggaagacatcaaaaaagaggcacagttagatgaagaaggacagtttcttgtcaga
ataatatatgatgactccaaaacttatgatttggttgctgctgcaagcaaagtcctcaat
ctcaatgctggagaaatcctccaaatgtttgggaagatgtttttcgtcttttgccaagaa
tctggttatgatacaatcttgcgtgtcctgggctctaatgtcagagaatttctacagaac
cttgatgctctgcacgaccaccttgctaccatctacccaggaatgcgtgcaccttccttt
aggtgcactgatgcagaaaagggcaaaggactcattttgcactactactcagagagagaa
ggacttcaggatattgtcattggaatcatcaaaacagtggcacaacaaatccatggcact
gaaatagacatgaaggttattcagcaaagaaatgaagaatgtgatcatactcaattttta
attgaagaaaaagagtcaaaagaagaggatttttatgaagatcttgacagatttgaagaa
aatggtacccaggaatcacgcatcagcccatatacattctgcaaagcttttccttttcat
ataatatttgaccgggacctagtggtcactcagtgtggcaatgctatatacagagttctc
ccccagctccagcctgggaattgcagccttctgtctgtcttctcgctggttcgtcctcat
attgatattagtttccatgggatcctttctcacatcaatactgtttttgtattgagaagc
aaggaaggattgttggatgtggagaaattagaatgtgaggatgaactgactgggactgag
atcagctgcttacgtctcaagggtcaaatgatctacttacctgaagcagatagcatactt
tttctatgttcaccaagtgtcatgaacctggacgatttgacaaggagagggctgtatcta
agtgacatccctctgcatgatgccacgcgcgatcttgttcttttgggagaacaatttaga
gaggaatacaaactcacccaagaactggaaatcctcactgacaggctacagctcacgtta
agagccctggaagatgaaaagaaaaagacagacacattgctgtattctgtccttcctccg
tctgttgccaatgagctgcggcacaagcgtccagtgcctgccaaaagatatgacaatgtg
accatcctctttagtggcattgtgggcttcaatgctttctgtagcaagcatgcatctgga
gaaggagccatgaagatcgtcaacctcctcaacgacctctacaccagatttgacacactg
actgattcccggaaaaacccatttgtttataaggtggagactgttggtgacaagtatatg
acagtgagtggtttaccagagccatgcattcaccatgcacgatccatctgccacctggcc
ttggacatgatggaaattgctggccaggttcaagtagatggtgaatctgttcagataaca
atagggatacacactggagaggtagttacaggtgtcataggacagcggatgcctcgatac
tgtctttttgggaatactgtcaacctcacaagccgaacagaaaccacaggagaaaaggga
aaaataaatgtgtctgaatatacatacagatgtcttatgtctccagaaaattcagatcca
caattccacttggagcacagaggcccagtgtccatgaagggcaaaaaagaaccaatgcaa
gtttggtttctatccagaaaaaatacaggaacagaggaaacaaagcaggatgatgactga
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