Homo sapiens (human): 6716 Help Entry 6716              CDS       T01001                                  Symbol SRD5A2 Name (RefSeq) steroid 5 alpha-reductase 2   KO K12344   3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:1.3.1.22] Organism hsa  Homo sapiens (human) Pathway hsa00140   Steroid hormone biosynthesis hsa01100   Metabolic pathways hsa05215   Prostate cancer Disease H00608   46,XY disorder of sex development due to testosterone secretion defect Drug target Alfatradiol:  D07121 Dutasteride:  D03820<JP/US> Epristeride:  D01134 Estramustine (DG00724):  D02398 D04066 D06397<JP/US> Finasteride:  D00321<JP/US> Idronoxil:  D04498 Izonsteride:  D04646 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09103 Lipid metabolism    00140 Steroid hormone biosynthesis     6716 (SRD5A2)  09160 Human Diseases   09162 Cancer: specific types    05215 Prostate cancer     6716 (SRD5A2) Enzymes [BR:hsa01000]  1. Oxidoreductases   1.3  Acting on the CH-CH group of donors    1.3.1  With NAD+ or NADP+ as acceptor     1.3.1.22  3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)      6716 (SRD5A2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Steroid_dh DUF1295 PEMT Motif Other DBs NCBI-GeneID:  6716 NCBI-ProteinID:  NP_000339 OMIM:  607306 HGNC:  11285 Ensembl:  ENSG00000277893 Vega:  OTTHUMG00000152057 Pharos:  P31213(Tclin) UniProt:  P31213 Structure PDB LinkDB All DBs Position 2:complement(31522480..31665651) Genome browser AA seq 254 aa AA seqDB search MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE DYPKSRKALIPFIF NT seq 765 nt NT seq  +upstreamnt  +downstreamnt atgcaggttcagtgccagcagagcccagtgctggcaggcagcgccactttggtcgccctt ggggcactggccttgtacgtcgcgaagccctccggctacgggaagcacacggagagcctg aagccggcggctacccgcctgccagcccgcgccgcctggttcctgcaggagctgccttcc ttcgcggtgcccgcggggatcctcgcccggcagcccctctccctcttcgggccacctggg acggtacttctgggcctcttctgcctacattacttccacaggacatttgtgtactcactg ctcaatcgagggaggccttatccagctatactcattctcagaggcactgccttctgcact ggaaatggagtccttcaaggctactatctgatttactgtgctgaataccctgatgggtgg tacacagacatacggtttagcttgggtgtcttcttatttattttgggaatgggaataaac attcatagtgactatatattgcgccagctcaggaagcctggagaaatcagctacaggatt ccacaaggtggcttgtttacgtatgtttctggagccaatttcctcggtgagatcattgaa tggatcggctatgccctggccacttggtccctcccagcacttgcatttgcatttttctca ctttgtttccttgggctgcgagcttttcaccaccataggttctacctcaagatgtttgag gactaccccaaatctcggaaagcccttattccattcatcttttaa

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