Homo sapiens (human): 6716
Entry
6716 CDS
T01001
Gene name
SRD5A2
Definition
(RefSeq) steroid 5 alpha-reductase 2
KO
K12344
3-oxo-5-alpha-steroid 4-dehydrogenase 2 [EC:
1.3.1.22
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00140
Steroid hormone biosynthesis
hsa05215
Prostate cancer
Disease
H00608
46,XY disorder of sex development due to testosterone secretion defect
Drug target
Alfatradiol:
D07121
Dutasteride:
D03820
Epristeride:
D01134
Estramustine (
DG00724
):
D02398
D04066
D06397
Finasteride:
D00321
Idronoxil:
D04498
Izonsteride:
D04646
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
6716 (SRD5A2)
09160 Human Diseases
09162 Cancer: specific types
05215 Prostate cancer
6716 (SRD5A2)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
6716 (SRD5A2)
SSDB
Motif
Pfam:
Steroid_dh
DUF1295
PEMT
Other DBs
NCBI-GeneID:
6716
NCBI-ProteinID:
NP_000339
OMIM:
607306
HGNC:
11285
Ensembl:
ENSG00000277893
Vega:
OTTHUMG00000152057
Pharos:
P31213
(Tclin)
UniProt:
P31213
LinkDB
Position
2p23.1
AA seq
254 aa
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPS
FAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCT
GNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRI
PQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFE
DYPKSRKALIPFIF
NT seq
765 nt
+upstream
nt +downstream
nt
atgcaggttcagtgccagcagagcccagtgctggcaggcagcgccactttggtcgccctt
ggggcactggccttgtacgtcgcgaagccctccggctacgggaagcacacggagagcctg
aagccggcggctacccgcctgccagcccgcgccgcctggttcctgcaggagctgccttcc
ttcgcggtgcccgcggggatcctcgcccggcagcccctctccctcttcgggccacctggg
acggtacttctgggcctcttctgcctacattacttccacaggacatttgtgtactcactg
ctcaatcgagggaggccttatccagctatactcattctcagaggcactgccttctgcact
ggaaatggagtccttcaaggctactatctgatttactgtgctgaataccctgatgggtgg
tacacagacatacggtttagcttgggtgtcttcttatttattttgggaatgggaataaac
attcatagtgactatatattgcgccagctcaggaagcctggagaaatcagctacaggatt
ccacaaggtggcttgtttacgtatgtttctggagccaatttcctcggtgagatcattgaa
tggatcggctatgccctggccacttggtccctcccagcacttgcatttgcatttttctca
ctttgtttccttgggctgcgagcttttcaccaccataggttctacctcaagatgtttgag
gactaccccaaatctcggaaagcccttattccattcatcttttaa
DBGET
integrated database retrieval system
