| Entry |
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|---|
| Name |
Dutasteride (JAN/USAN/INN);
Avodart (TN)
|
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| Product |
|
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| Generic |
DUTASTERIDE (A-S Medication Solutions), DUTASTERIDE (Actavis Pharma), DUTASTERIDE (Amneal Pharmaceuticals of New York), DUTASTERIDE (Apotex Corp.), DUTASTERIDE (AvKARE), DUTASTERIDE (AvPAK), DUTASTERIDE (Breckenridge Pharmaceutical), DUTASTERIDE (Cadila Healthcare Limited), DUTASTERIDE (Camber Pharmaceuticals), DUTASTERIDE (Epic Pharma), DUTASTERIDE (Golden State Medical Supply), DUTASTERIDE (Humanwell PuraCap Pharmaceutical (Wuhan)), DUTASTERIDE (Impax Generics), DUTASTERIDE (Intergel Pharmaceuticals), DUTASTERIDE (MARKSANS PHARMA LIMITED), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (Proficient Rx LP), DUTASTERIDE (Proficient Rx LP), DUTASTERIDE (PuraCap Pharmaceutical LLC), DUTASTERIDE (Rising Pharmaceuticals), DUTASTERIDE (Strides Shasun Limited), DUTASTERIDE (Teva Pharmaceuticals USA), DUTASTERIDE (Vensun Pharmaceuticals), DUTASTERIDE (West-Ward Pharmaceuticals Corp.), DUTASTERIDE (Zydus Pharmaceuticals (USA)) |
|---|
| Formula |
C27H30F6N2O2
|
|---|
| Exact mass |
528.2211
|
|---|
| Mol weight |
528.5297
|
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| Structure |
   |
|---|
| Class |
Enzyme substrate
DG01633 CYP3A substrate
|
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| Remark |
| Therapeutic category: | 2499 |
|
|---|
| Efficacy |
Prostatic hyperplasia treatment, Antiandrogen, 5alpha-Reductase inhibitor |
|---|
| Comment |
Treatment of benign prostatic hyperplasia
|
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| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
G04CB Testosterone-5-alpha reductase inhibitors
G04CB02 Dutasteride
D03820 Dutasteride (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Genitourinary Agents
Benign Prostatic Hypertrophy Agents
Dutasteride
D03820 Dutasteride (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
249 Miscellaneous
2499 Others
D03820 Dutasteride (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
SRD5A1
D03820 Dutasteride (JAN/USAN/INN) <JP/US>
SRD5A2
D03820 Dutasteride (JAN/USAN/INN) <JP/US>
Drug classes of therapeutic agents [br08360.html]
Endocrine and hormonal agents
D03820
New drug approvals in the USA [br08319.html]
New Molecular Entity and New Therapeutic Biological Product Approvals
D03820
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D03820
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D03820
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 37
1 C2x C 28.5514 -21.3770
2 C5x C 28.5514 -22.7540
3 N1x N 29.7439 -23.4425
4 C1y C 30.9364 -22.7540
5 C1z C 30.9364 -21.3770
6 C2x C 29.7439 -20.6885
7 C1x C 32.1289 -23.4425
8 C1x C 33.3214 -22.7540
9 C1y C 33.3214 -21.3770
10 C1y C 32.1289 -20.6885
11 C1y C 34.5140 -20.6885
12 C1z C 34.5140 -19.3115
13 C1x C 33.3214 -18.6230
14 C1x C 32.1289 -19.3115
15 C1x C 36.8990 -20.6885
16 C1x C 36.8990 -19.3115
17 C1y C 35.7065 -18.6230
18 C5a C 35.7065 -17.2460
19 N1b N 36.9030 -16.5552
20 O5a O 34.5180 -16.5597
21 C8y C 38.0809 -17.2353
22 C8x C 38.0810 -18.6227
23 C8y C 39.2735 -19.3111
24 C8x C 40.4660 -18.6226
25 C8x C 40.4660 -17.2352
26 C8y C 39.2734 -16.5468
27 C1d C 39.2734 -15.1698
28 X F 40.6504 -15.1698
29 X F 39.2734 -13.7928
30 X F 37.8964 -15.1698
31 C1d C 39.2735 -20.6881
32 X F 37.8964 -20.6881
33 X F 40.6505 -20.6881
34 X F 39.2735 -22.0651
35 O5x O 27.3589 -23.4425
36 C1a C 30.9364 -20.0000
37 C1a C 34.5140 -17.9345
BOND 41
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 17 18 1 #Up
22 18 19 1
23 18 20 2
24 19 21 1
25 21 22 2
26 22 23 1
27 23 24 2
28 24 25 1
29 25 26 2
30 21 26 1
31 26 27 1
32 27 28 1
33 27 29 1
34 27 30 1
35 23 31 1
36 31 32 1
37 31 33 1
38 31 34 1
39 2 35 2
40 5 36 1 #Up
41 12 37 1 #Up
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