KEGG   DRUG: Dutasteride
Entry
D03820                      Drug                                   
Name
Dutasteride (JAN/USP/INN);
Avodart (TN)
Product
AVODART (Waylis Therapeutics LLC)
  Generic
DUTASTERIDE (A-S Medication Solutions), DUTASTERIDE (A-S Medication Solutions), DUTASTERIDE (Amneal Pharmaceuticals LLC), DUTASTERIDE (Aurobindo Pharma Limited), DUTASTERIDE (Bryant Ranch Prepack), DUTASTERIDE (Bryant Ranch Prepack), DUTASTERIDE (Bryant Ranch Prepack), DUTASTERIDE (Bryant Ranch Prepack), DUTASTERIDE (Camber Pharmaceuticals), DUTASTERIDE (Epic Pharma), DUTASTERIDE (Golden State Medical Supply), DUTASTERIDE (MARKSANS PHARMA LIMITED), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (NuCare Pharmaceuticals), DUTASTERIDE (Proficient Rx LP), DUTASTERIDE (Proficient Rx LP), DUTASTERIDE (Viona Pharmaceuticals), DUTASTERIDE (XLCare Pharmaceuticals), DUTASTERIDE (Zydus Lifesciences Limited)
Formula
C27H30F6N2O2
Exact mass
528.2211
Mol weight
528.53
Structure
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Therapeutic category: 2499
ATC code: G04CB02
Product: D03820<JP/US>
Product (mixture): D11389<US>
Efficacy
Prostatic hyperplasia treatment, Antiandrogen, 5alpha-Reductase inhibitor
Comment
Treatment of benign prostatic hyperplasia
Target
SRD5A1 [HSA:6715] [KO:K12343]
SRD5A2 [HSA:6716] [KO:K12344]
  Pathway
hsa00140  Steroid hormone biosynthesis
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CB Testosterone-5-alpha reductase inhibitors
     G04CB02 Dutasteride
      D03820  Dutasteride (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Dutasteride
    D03820  Dutasteride (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D03820  Dutasteride (JAN/USP/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D03820  Dutasteride
  DG02925  CYP3A5 substrate
   D03820  Dutasteride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SRD5A1
     D03820  Dutasteride (JAN/USP/INN) <JP/US>
    SRD5A2
     D03820  Dutasteride (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03820
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03820
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03820
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03820
Other DBs
CAS: 164656-23-9
PubChem: 17397907
ChEBI: 521033
LigandBox: D03820
LinkDB
KCF data

ATOM        37
            1   C2x C    28.5514  -21.3770
            2   C5x C    28.5514  -22.7540
            3   N1x N    29.7439  -23.4425
            4   C1y C    30.9364  -22.7540
            5   C1z C    30.9364  -21.3770
            6   C2x C    29.7439  -20.6885
            7   C1x C    32.1289  -23.4425
            8   C1x C    33.3214  -22.7540
            9   C1y C    33.3214  -21.3770
            10  C1y C    32.1289  -20.6885
            11  C1y C    34.5140  -20.6885
            12  C1z C    34.5140  -19.3115
            13  C1x C    33.3214  -18.6230
            14  C1x C    32.1289  -19.3115
            15  C1x C    36.8990  -20.6885
            16  C1x C    36.8990  -19.3115
            17  C1y C    35.7065  -18.6230
            18  C5a C    35.7065  -17.2460
            19  N1b N    36.9030  -16.5552
            20  O5a O    34.5180  -16.5597
            21  C8y C    38.0809  -17.2353
            22  C8x C    38.0810  -18.6227
            23  C8y C    39.2735  -19.3111
            24  C8x C    40.4660  -18.6226
            25  C8x C    40.4660  -17.2352
            26  C8y C    39.2734  -16.5468
            27  C1d C    39.2734  -15.1698
            28  X   F    40.6504  -15.1698
            29  X   F    39.2734  -13.7928
            30  X   F    37.8964  -15.1698
            31  C1d C    39.2735  -20.6881
            32  X   F    37.8964  -20.6881
            33  X   F    40.6505  -20.6881
            34  X   F    39.2735  -22.0651
            35  O5x O    27.3589  -23.4425
            36  C1a C    30.9364  -20.0000
            37  C1a C    34.5140  -17.9345
BOND        41
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21   17  18 1 #Up
            22   18  19 1
            23   18  20 2
            24   19  21 1
            25   21  22 2
            26   22  23 1
            27   23  24 2
            28   24  25 1
            29   25  26 2
            30   21  26 1
            31   26  27 1
            32   27  28 1
            33   27  29 1
            34   27  30 1
            35   23  31 1
            36   31  32 1
            37   31  33 1
            38   31  34 1
            39    2  35 2
            40    5  36 1 #Up
            41   12  37 1 #Up

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