KEGG   Homo sapiens (human): 7480
Entry
7480              CDS       T01001                                 

Gene name
WNT10B, SHFM6, STHAG8, WNT-12
Definition
(RefSeq) Wnt family member 10B
  KO
K01357  wingless-type MMTV integration site family, member 10
Organism
hsa  Homo sapiens (human)
Pathway
hsa04150  mTOR signaling pathway
hsa04310  Wnt signaling pathway
hsa04390  Hippo signaling pathway
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04916  Melanogenesis
hsa04934  Cushing syndrome
hsa05010  Alzheimer disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05165  Human papillomavirus infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05217  Basal cell carcinoma
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06115  WNT signaling (viruses and bacteria)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06215  WNT signaling
nt06217  HH signaling
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06263  Hepatocellular carcinoma
nt06269  Basal cell carcinoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06274  Thyroid cancer
  Element
N00010  Mutation-inactivated PTCH1 to Hedgehog signaling pathway
N00017  Mutation-activated SMO to Hedgehog signaling pathway
N00056  Wnt signaling pathway
N00059  FZD7-overexpression to Wnt signaling pathway
N00060  LRP6-overexpression to Wnt signaling pathway
Disease
H00471  Split-hand/foot malformation
H00625  Tooth agenesis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    7480 (WNT10B)
   04390 Hippo signaling pathway
    7480 (WNT10B)
   04150 mTOR signaling pathway
    7480 (WNT10B)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    7480 (WNT10B)
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    7480 (WNT10B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    7480 (WNT10B)
   05205 Proteoglycans in cancer
    7480 (WNT10B)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    7480 (WNT10B)
   05226 Gastric cancer
    7480 (WNT10B)
   05217 Basal cell carcinoma
    7480 (WNT10B)
   05224 Breast cancer
    7480 (WNT10B)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7480 (WNT10B)
   05022 Pathways of neurodegeneration - multiple diseases
    7480 (WNT10B)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    7480 (WNT10B)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    7480 (WNT10B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins [BR:hsa00536]
    7480 (WNT10B)
Glycosaminoglycan binding proteins [BR:hsa00536]
 Heparan sulfate / Heparin
  Morphogens
   7480 (WNT10B)
SSDB
Motif
Pfam: wnt
Other DBs
NCBI-GeneID: 7480
NCBI-ProteinID: NP_003385
OMIM: 601906
HGNC: 12775
Ensembl: ENSG00000169884
Vega: OTTHUMG00000150734
Pharos: O00744(Tbio)
UniProt: O00744
LinkDB
Position
12q13.12
AA seq 389 aa
MLEEPRPRPPPSGLAGLLFLALCSRALSNEILGLKLPGEPPLTANTVCLTLSGLSKRQLG
LCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHSAILKRGFRESAFS
FSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKLLQLQALSRGKSFPHSLPSP
GPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQARMRIHNNRVGRQVVT
ENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFIDTHNRNSGAFQPRLR
PRRLSGELVYFEKSPDFCERDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTR
VERCHCRFHWCCYVLCDECKVTEWVNVCK
NT seq 1170 nt   +upstreamnt  +downstreamnt
atgctggaggagccccggccgcggcctccgccctcgggcctcgcgggtctcctgttcctg
gcgttgtgcagtcgggctctaagcaatgagattctgggcctgaagttgcctggcgagccg
ccgctgacggccaacaccgtgtgcttgacgctgtccggcctgagcaagcggcagctaggc
ctgtgcctgcgcaaccccgacgtgacggcgtccgcgcttcagggtctgcacatcgcggtc
cacgagtgtcagcaccagctgcgcgaccagcgctggaactgctccgcgcttgagggcggc
ggccgcctgccgcaccacagcgccatcctcaagcgcggtttccgagaaagtgctttttcc
ttctccatgctggctgctggggtcatgcacgcagtagccacggcctgcagcctgggcaag
ctggtgagctgtggctgtggctggaagggcagtggtgagcaggatcggctgagggccaaa
ctgctgcagctgcaggcactgtcccgaggcaagagtttcccccactctctgcccagccct
ggccctggctcaagccccagccctggcccccaggacacatgggaatggggtggctgtaac
catgacatggactttggagagaagttctctcgggatttcttggattccagggaagctccc
cgggacatccaggcacgaatgcgaatccacaacaacagggtggggcgccaggtggtaact
gaaaacctgaagcggaaatgcaagtgtcatggcacatcaggcagctgccagttcaagaca
tgctggagggcggccccagagttccgggcagtgggggcggcgttgagggagcggctgggc
cgggccatcttcattgatacccacaaccgcaattctggagccttccagccccgtctgcgt
ccccgtcgcctctcaggagagctggtctactttgagaagtctcctgacttctgtgagcga
gaccccactatgggctccccagggacaaggggccgggcctgcaacaagaccagccgcctg
ttggatggctgtggcagcctgtgctgtggccgtgggcacaacgtgctccggcagacacga
gttgagcgctgccattgccgcttccactggtgctgctatgtgctgtgtgatgagtgcaag
gttacagagtgggtgaatgtgtgtaagtga

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